Entity Details

Primary name PPARGC1A
Entity type gene
Source Source Link

Details

PrimaryID10891
RefseqGeneNG_028250
SymbolPPARGC1A
NamePPARG coactivator 1 alpha
Chromosome4
Location4p15.2
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-03-05
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsPRGC1_HUMAN

GO terms

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GOName
GO:0000302 response to reactive oxygen species
GO:0000422 autophagy of mitochondrion
GO:0000785 chromatin
GO:0000791 euchromatin
GO:0001659 temperature homeostasis
GO:0001678 cellular glucose homeostasis
GO:0001933 negative regulation of protein phosphorylation
GO:0002021 response to dietary excess
GO:0002931 response to ischemia
GO:0003677 DNA binding
GO:0003712 transcription coregulator activity
GO:0003713 transcription coactivator activity
GO:0003723 RNA binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0006012 galactose metabolic process
GO:0006094 gluconeogenesis
GO:0006355 regulation of transcription, DNA-templated
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006397 mRNA processing
GO:0007005 mitochondrion organization
GO:0007568 aging
GO:0007586 digestion
GO:0007623 circadian rhythm
GO:0008134 transcription factor binding
GO:0008209 androgen metabolic process
GO:0008380 RNA splicing
GO:0009409 response to cold
GO:0010628 positive regulation of gene expression
GO:0010822 positive regulation of mitochondrion organization
GO:0014732 skeletal muscle atrophy
GO:0014850 response to muscle activity
GO:0014878 response to electrical stimulus involved in regulation of muscle adaptation
GO:0014912 negative regulation of smooth muscle cell migration
GO:0016605 PML body
GO:0016922 nuclear receptor binding
GO:0019395 fatty acid oxidation
GO:0021549 cerebellum development
GO:0022626 cytosolic ribosome
GO:0022904 respiratory electron transport chain
GO:0030331 estrogen receptor binding
GO:0030374 nuclear receptor coactivator activity
GO:0030900 forebrain development
GO:0031490 chromatin DNA binding
GO:0031625 ubiquitin protein ligase binding
GO:0032922 circadian regulation of gene expression
GO:0034599 cellular response to oxidative stress
GO:0035066 positive regulation of histone acetylation
GO:0035865 cellular response to potassium ion
GO:0042493 response to drug
GO:0042594 response to starvation
GO:0042752 regulation of circadian rhythm
GO:0042975 peroxisome proliferator activated receptor binding
GO:0043014 alpha-tubulin binding
GO:0043025 neuronal cell body
GO:0043201 response to leucine
GO:0043231 intracellular membrane-bounded organelle
GO:0043524 negative regulation of neuron apoptotic process
GO:0043565 sequence-specific DNA binding
GO:0045333 cellular respiration
GO:0045722 positive regulation of gluconeogenesis
GO:0045820 negative regulation of glycolytic process
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046321 positive regulation of fatty acid oxidation
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0048662 negative regulation of smooth muscle cell proliferation
GO:0050821 protein stabilization
GO:0050873 brown fat cell differentiation
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051552 flavone metabolic process
GO:0060612 adipose tissue development
GO:0065003 protein-containing complex assembly
GO:0071222 cellular response to lipopolysaccharide
GO:0071250 cellular response to nitrite
GO:0071313 cellular response to caffeine
GO:0071332 cellular response to fructose stimulus
GO:0071333 cellular response to glucose stimulus
GO:0071354 cellular response to interleukin-6
GO:0071356 cellular response to tumor necrosis factor
GO:0071372 cellular response to follicle-stimulating hormone stimulus
GO:0071392 cellular response to estradiol stimulus
GO:0071456 cellular response to hypoxia
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0071871 response to epinephrine
GO:0071873 response to norepinephrine
GO:0090258 negative regulation of mitochondrial fission
GO:0097009 energy homeostasis
GO:0097067 cellular response to thyroid hormone stimulus
GO:0097440 apical dendrite
GO:0120162 positive regulation of cold-induced thermogenesis
GO:1901215 negative regulation of neuron death
GO:1901558 response to metformin
GO:1901857 positive regulation of cellular respiration
GO:1901860 positive regulation of mitochondrial DNA metabolic process
GO:1901863 positive regulation of muscle tissue development
GO:1904635 positive regulation of glomerular visceral epithelial cell apoptotic process
GO:1904637 cellular response to ionomycin
GO:1904639 cellular response to resveratrol
GO:1904640 response to methionine
GO:1990841 promoter-specific chromatin binding
GO:1990845 adaptive thermogenesis
GO:2000184 positive regulation of progesterone biosynthetic process
GO:2000272 negative regulation of signaling receptor activity
GO:2000310 regulation of NMDA receptor activity
GO:2001171 positive regulation of ATP biosynthetic process

Diseases

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Interactions

76 interactions

InteractorPartnerSourcesPublicationsLink
PPARGC1ALRPPRCBioGRID, UniProt17050673 details
PPARGC1AESRRGBioGRID, HPRD, IntAct, MINT12181319 12470660 15821111 18063693 19171140 19914244 32296183 details
PPARGC1APPARGBioGRID, HPRD, IntAct, MINT10558993 12502716 12522104 14636573 15026545 17011503 17468099 17513608 17704298 17785586 18469005 18674809 19596656 19631645 19846556 22070604 23178929 30595551 30651555 details
PPARGC1ACAPNS1BioGRID, IntAct21988832 details
PPARGC1ACDK6BioGRID, IntAct22094256 details
PPARGC1ARORCIntAct20203100 details
PPARGC1AHNF4ABioGRID, HPRD, IntAct15322103 15331348 15744310 15826954 17636037 18552123 19846556 20926756 22009745 22155889 details
PPARGC1ARARBBioGRID, IntAct32296183 details
PPARGC1AESRRABioGRID, HPRD, IntAct12181319 12522104 15337744 18063693 18441008 32296183 details
PPARGC1APPARABioGRID, IntAct10669761 21775429 details
PPARGC1APPARDBioGRID, IntAct19596656 21775429 details
PPARGC1ANR5A2BioGRID, DIP17283069 20133449 22504882 details
PPARGC1AESR1BioGRID, HPRD, IntAct10748020 12522104 18441008 details
PPARGC1ARXRABioGRID, HPRD, IntAct11714715 12522104 details
PPARGC1ANR1H4BioGRID, HPRD14729567 details
PPARGC1AMED1BioGRID, HPRD14636573 details
PPARGC1AMED17BioGRID14636573 details
PPARGC1AMED12BioGRID14636573 details
PPARGC1AMED14BioGRID14636573 details
PPARGC1ATHRBBioGRID, HPRD11751919 details
PPARGC1ANRF1BioGRID, HPRD10412986 11943463 details
PPARGC1ANR3C1BioGRID, HPRD10713165 18160712 details
PPARGC1ANCOA1BioGRID, HPRD10558993 details
PPARGC1ACREBBPBioGRID10558993 details
PPARGC1AFBXW7BioGRID, HPRD18198341 details
PPARGC1AGSK3BBioGRID, HPRD18198341 details
PPARGC1ASIRT1BioGRID, HPRD15716268 15744310 19553684 details
PPARGC1ANCOA6BioGRID18552123 details
PPARGC1ANR1I2BioGRID, HPRD15322103 15331348 15604093 16455805 details
PPARGC1AESR2BioGRID, HPRD15604093 15784253 details
PPARGC1ATP53BioGRID22099309 details
PPARGC1AUBE2IBioGRID19625249 details
PPARGC1ACREB3L3BioGRID21994947 details
PPARGC1AUSF2BioGRID, HPRD12611894 details
PPARGC1AUSF1BioGRID12611894 details
PPARGC1ANR1I3BioGRID, HPRD15572376 26407237 details
PPARGC1ASKP1BioGRID26407237 details
PPARGC1ANDNBioGRID26971449 details
PPARGC1ARELABioGRID, IntAct17785586 23174781 details
PPARGC1APRKAA2DIP17609368 details
PPARGC1AMED16BioGRID14636573 details
PPARGC1AMED21BioGRID14636573 details
PPARGC1AMED20BioGRID14636573 details
PPARGC1AHCFC1BioGRID, HPRD11733490 details
PPARGC1ASRSF5BioGRID, HPRD10983978 details
PPARGC1ASRSF6BioGRID, HPRD10983978 details
PPARGC1ASRSF4BioGRID, HPRD10983978 details
PPARGC1ASRSF2BioGRID10983978 details
PPARGC1AEP300BioGRID17050673 details
PPARGC1AIQGAP1BioGRID17050673 details
PPARGC1AMYOD1BioGRID19553684 details
PPARGC1AMYEF2BioGRID15111488 details
PPARGC1ASF1BioGRID20133449 details
PPARGC1ARNF34BioGRID22064484 details
PPARGC1ARNF2BioGRID22099309 details
PPARGC1APIAS1BioGRID22969086 details
PPARGC1ASFPQBioGRID18689799 details
PPARGC1AEGFRBioGRID23956138 details
PPARGC1APRKAA1BioGRID24371122 details
PPARGC1AKAT2ABioGRID24371122 details
PPARGC1ANRIP1BioGRID19625249 details
PPARGC1ANFKB1BioGRID17785586 details
PPARGC1AEWSR1BioGRID25918410 details
PPARGC1APMLBioGRID26407237 details
PPARGC1ANR4A2BioGRID21757690 details
PPARGC1ATNFAIP3BioGRID29678181 details
PPARGC1AMAPK14HPRD11741533 details
PPARGC1AMYBBP1AHPRD14744933 details
PPARGC1AUBCHPRD18198341 details
PPARGC1ANCLHPRD10983978 details
PPARGC1ABCL6BioGRID, IntAct16147992 details
PPARGC1AH2BC21BioGRID, IntAct30021884 details
PPARGC1ACYP7A1bhf-ucl16488887 details
PPARGC1APDK4IntAct25609694 details
PPARGC1AABCB11IntAct25675114 details
PPARGC1AVIRMABioGRID29507755 details