Entity Details

Primary name NLRP3
Entity type gene
Source Source Link

Details

PrimaryID114548
RefseqGeneNG_007509
SymbolNLRP3
NameNLR family pyrin domain containing 3
Chromosome1
Location1q44
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2001-09-10
ModificationDate2021-06-20

Ontological Relatives

UniProt IDsNLRP3_HUMAN

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0002523 leukocyte migration involved in inflammatory response
GO:0002674 negative regulation of acute inflammatory response
GO:0002830 positive regulation of type 2 immune response
GO:0005524 ATP binding
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0006915 apoptotic process
GO:0006952 defense response
GO:0006954 inflammatory response
GO:0007165 signal transduction
GO:0008134 transcription factor binding
GO:0009595 detection of biotic stimulus
GO:0014070 response to organic cyclic compound
GO:0016579 protein deubiquitination
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032691 negative regulation of interleukin-1 beta production
GO:0032731 positive regulation of interleukin-1 beta production
GO:0032753 positive regulation of interleukin-4 production
GO:0035590 purinergic nucleotide receptor signaling pathway
GO:0042802 identical protein binding
GO:0042834 peptidoglycan binding
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043565 sequence-specific DNA binding
GO:0045087 innate immune response
GO:0045471 response to ethanol
GO:0045630 positive regulation of T-helper 2 cell differentiation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0050728 negative regulation of inflammatory response
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0071222 cellular response to lipopolysaccharide
GO:0072559 NLRP3 inflammasome complex
GO:1901223 negative regulation of NIK/NF-kappaB signaling
GO:2000553 positive regulation of T-helper 2 cell cytokine production

Diseases

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Interactions

81 interactions

InteractorPartnerSourcesPublicationsLink
NLRP3PYCARDBioGRID, DIP, HPRD, IntAct, UniProt11786556 15020601 19158675 24630722 28229991 30182366 30653357 32003754 32435622 details
NLRP3NLRP3IntAct23582325 24630722 details
NLRP3SYKIntAct25605870 details
NLRP3EIF2AK2DIP22801494 details
NLRP3NEK7BioGRID, DIP, IntAct26814970 31189953 31762063 31866999 32814053 details
NLRP3CALRIntAct32814053 details
NLRP3DLSTIntAct32814053 details
NLRP3FAF1BioGRID17046979 details
NLRP3FBXL2BioGRID26037928 details
NLRP3TRIM31BioGRID27929086 32323100 32716108 details
NLRP3CUL1BioGRID30653357 details
NLRP3PGM1BioGRID30653357 details
NLRP3ATP1B3BioGRID30653357 details
NLRP3VDRBioGRID31866999 details
NLRP3STAMBPBioGRID32003754 details
NLRP3MAP1LC3AInnateDB22286270 details
NLRP3MAVSDIP, IntAct23582325 26494172 details
NLRP3CARD8HPRD, IntAct15030775 28137891 details
NLRP3NLRC4BioGRID15107016 details
NLRP3SUGT1BioGRID17435760 details
NLRP3HSP90AA1BioGRID17435760 details
NLRP3DHX33BioGRID25172487 details
NLRP3ULK1BioGRID26347139 details
NLRP3MEFVBioGRID26347139 details
NLRP3STUB1BioGRID25594175 details
NLRP3MARCHF7BioGRID25594175 details
NLRP3UBR5BioGRID25594175 details
NLRP3HDAC6BioGRID26471297 details
NLRP3USP50BioGRID28094437 details
NLRP3ARIH2BioGRID29021376 details
NLRP3TXNIPBioGRID28326454 30833078 details
NLRP3RBX1BioGRID30653357 details
NLRP3ABRAXAS2BioGRID30787184 details
NLRP3BRCC3BioGRID30787184 31866999 details
NLRP3CASP8BioGRID30182366 details
NLRP3P2RY2BioGRID31553908 details
NLRP3SRCBioGRID31553908 details
NLRP3MARK4BioGRID31167564 details
NLRP3SQSTM1BioGRID32003754 details
NLRP3CBLBBioGRID31999304 details
NLRP3RNF125BioGRID31999304 details
NLRP3IL1BBioGRID32597834 details
NLRP3KIAA2013BioGRID, IntAct26496610 details
NLRP3SPASTBioGRID, IntAct26496610 details
NLRP3CBX3BioGRID, IntAct26496610 details
NLRP3FBXO28BioGRID, IntAct26496610 details
NLRP3H1-5BioGRID, IntAct26496610 details
NLRP3GEMIN2BioGRID, IntAct26496610 details
NLRP3NLRP5BioGRID, IntAct26496610 details
NLRP3COPS7ABioGRID, IntAct26496610 details
NLRP3URB1BioGRID, IntAct26496610 details
NLRP3LUC7LBioGRID, IntAct26496610 details
NLRP3FBXL6BioGRID, IntAct26496610 details
NLRP3SMARCA5BioGRID, IntAct26496610 details
NLRP3UQCRQBioGRID, IntAct26496610 details
NLRP3DNAJA2BioGRID, IntAct26496610 details
NLRP3TOP1BioGRID, IntAct26496610 details
NLRP3NECTIN3BioGRID, IntAct26496610 details
NLRP3LTBP4BioGRID, IntAct26496610 details
NLRP3LUC7L3BioGRID, IntAct26496610 details
NLRP3CBX5BioGRID, IntAct26496610 details
NLRP3RBBP7BioGRID, IntAct26496610 details
NLRP3PHF14BioGRID, IntAct26496610 details
NLRP3MTCH1BioGRID, IntAct26496610 details
NLRP3YBX3BioGRID, IntAct26496610 details
NLRP3DMAP1BioGRID, IntAct26496610 details
NLRP3AP3B1BioGRID, IntAct26496610 details
NLRP3ZC3H8BioGRID, IntAct26496610 details
NLRP3FEM1ABioGRID, IntAct26496610 details
NLRP3HNRNPCBioGRID, IntAct26496610 details
NLRP3PCGF5BioGRID, IntAct26496610 details
NLRP3SNRPBBioGRID, IntAct26496610 details
NLRP3CCDC86BioGRID, IntAct26496610 details
NLRP3HSPD1BioGRID, IntAct30021884 details
NLRP3TGOLN2MINT31231549 details
NLRP3MCFD2BioGRID26344197 details
NLRP3ARHGAP17BioGRID26344197 details
NLRP3SH3BP1BioGRID26344197 details
NLRP3PHRF1BioGRID26496610 details
NLRP3CUL4ABioGRID30945288 details
NLRP3CUL4BBioGRID30945288 details