Entity Details

Primary name SIX5
Entity type gene
Source Source Link

Details

PrimaryID147912
RefseqGeneNG_012745
SymbolSIX5
NameSIX homeobox 5
Chromosome19
Location19q13.32
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2002-01-22
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsSIX5_HUMAN

GO terms

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GOName
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0002088 lens development in camera-type eye
GO:0005634 nucleus
GO:0005667 transcription regulator complex
GO:0005737 cytoplasm
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007286 spermatid development
GO:0045892 negative regulation of transcription, DNA-templated
GO:1902723 negative regulation of skeletal muscle satellite cell proliferation

Diseases

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Disease IDSourceNameDescription
610896 OMIMBranchiootorenal syndrome 2 (BOR2)A syndrome characterized by branchial cleft fistulas or cysts, sensorineural and/or conductive hearing loss, pre-auricular pits, structural defects of the outer, middle or inner ear, and renal malformations. The disease is caused by variants affecting the gene represented in this entry.

Interactions

7 interactions

InteractorPartnerSourcesPublicationsLink
SIX5ATXN1BioGRID, HPRD, IntAct16713569 details
SIX5EYA3BioGRID, HPRD10490620 details
SIX5HMGB1HPRD11748221 details
SIX5FOXB1BioGRID, MINT25609649 details
SIX5FOXL1BioGRID, MINT25609649 details
SIX5ERCC3BioGRID22939629 details
SIX5SNX25BioGRID22939629 details