Entity Details

Primary name IRF5_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13568
EntryNameIRF5_HUMAN
FullNameInterferon regulatory factor 5
TaxID9606
Evidenceevidence at protein level
Length498
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesIRF5

GO terms

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GOName
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0002376 immune system process
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006954 inflammatory response
GO:0019221 cytokine-mediated signaling pathway
GO:0019901 protein kinase binding
GO:0032481 positive regulation of type I interferon production
GO:0032494 response to peptidoglycan
GO:0032495 response to muramyl dipeptide
GO:0032727 positive regulation of interferon-alpha production
GO:0032728 positive regulation of interferon-beta production
GO:0032735 positive regulation of interleukin-12 production
GO:0042802 identical protein binding
GO:0043065 positive regulation of apoptotic process
GO:0043565 sequence-specific DNA binding
GO:0045087 innate immune response
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0051607 defense response to virus
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0060337 type I interferon signaling pathway
GO:1990837 sequence-specific double-stranded DNA binding

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001346 Interferon regulatory factor DNA-binding domainDomainDomain
IPR008984 SMAD/FHA domain superfamilyFamilyHomologous superfamily
IPR017855 SMAD-like domain superfamilyFamilyHomologous superfamily
IPR019471 Interferon regulatory factor-3DomainDomain
IPR019817 Interferon regulatory factor, conserved siteSiteConserved site
IPR029838 Interferon regulatory factor 5FamilyFamily
IPR036388 Winged helix-like DNA-binding domain superfamilyFamilyHomologous superfamily
IPR036390 Winged helix DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

33 interactions

InteractorPartnerSourcesPublicationsLink
IRF5_HUMANCBP_HUMANBioGRID, DIP18836453 20935208 details
IRF5_HUMANSIN3A_HUMANBioGRID20935208 details
IRF5_HUMANEP300_HUMANBioGRID20935208 details
IRF5_HUMANMAVS_HUMANBioGRID, IntAct21903422 details
IRF5_HUMANIRF5_HUMANBioGRID, DIP, HPRD12138184 18836453 19786094 details
IRF5_HUMANTRI15_HUMANBioGRID, IntAct20211142 details
IRF5_HUMANRO52_HUMANBioGRID25084355 details
IRF5_HUMANCSN3_HUMANBioGRID29339435 details
IRF5_HUMANSGTA_HUMANBioGRID, IntAct21988832 details
IRF5_HUMANHDAC1_HUMANBioGRID20935208 details
IRF5_HUMANNCOR2_HUMANBioGRID20935208 details
IRF5_HUMANIRF3_HUMANBioGRID, HPRD11303025 12138184 details
IRF5_HUMANPPBI_HUMANBioGRID19786094 details
IRF5_HUMANMYD88_HUMANBioGRID, HPRD15665823 details
IRF5_HUMANTRAF6_HUMANBioGRID, HPRD15665823 32494619 details
IRF5_HUMANCSN1_HUMANBioGRID, IntAct21903422 29339435 details
IRF5_HUMANPELI1_HUMANBioGRID28746869 details
IRF5_HUMANTBK1_HUMANHPRD15556946 15695821 details
IRF5_HUMANCSN7A_HUMANBioGRID29339435 details
IRF5_HUMANXPO1_HUMANHPRD15556946 details
IRF5_HUMANIKKA_HUMANBioGRID19786094 details
IRF5_HUMANCSN8_HUMANBioGRID29339435 details
IRF5_HUMANBIRC3_HUMANBioGRID25565375 details
IRF5_HUMANIKKE_HUMANHPRD15556946 15695821 details
IRF5_HUMANOGA_HUMANBioGRID32494619 details
IRF5_HUMANNCOR1_HUMANBioGRID20935208 details
IRF5_HUMANCSN4_HUMANBioGRID29339435 details
IRF5_HUMANCSN2_HUMANBioGRID29339435 details
IRF5_HUMANTF65_HUMANIntAct20237317 details
IRF5_HUMANOGT1_HUMANBioGRID32494619 details
IRF5_HUMANKAT2B_HUMANBioGRID20935208 details
IRF5_HUMANCSN5_HUMANBioGRID29339435 details
IRF5_HUMANCSN6_HUMANBioGRID29339435 details