Entity Details

Primary name PTC1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13635
EntryNamePTC1_HUMAN
FullNameProtein patched homolog 1
TaxID9606
Evidenceevidence at protein level
Length1447
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesPTCH1

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001701 in utero embryonic development
GO:0001709 cell fate determination
GO:0001843 neural tube closure
GO:0003007 heart morphogenesis
GO:0005113 patched binding
GO:0005119 smoothened binding
GO:0005634 nucleus
GO:0005886 plasma membrane
GO:0005901 caveola
GO:0007224 smoothened signaling pathway
GO:0007346 regulation of mitotic cell cycle
GO:0007420 brain development
GO:0008158 hedgehog receptor activity
GO:0008201 heparin binding
GO:0008589 regulation of smoothened signaling pathway
GO:0009612 response to mechanical stimulus
GO:0009887 animal organ morphogenesis
GO:0009953 dorsal/ventral pattern formation
GO:0009957 epidermal cell fate specification
GO:0010157 response to chlorate
GO:0010875 positive regulation of cholesterol efflux
GO:0014069 postsynaptic density
GO:0015485 cholesterol binding
GO:0016021 integral component of membrane
GO:0016485 protein processing
GO:0021522 spinal cord motor neuron differentiation
GO:0021532 neural tube patterning
GO:0021997 neural plate axis specification
GO:0030326 embryonic limb morphogenesis
GO:0030332 cyclin binding
GO:0030496 midbody
GO:0030666 endocytic vesicle membrane
GO:0030850 prostate gland development
GO:0032355 response to estradiol
GO:0032526 response to retinoic acid
GO:0032880 regulation of protein localization
GO:0035108 limb morphogenesis
GO:0035137 hindlimb morphogenesis
GO:0040015 negative regulation of multicellular organism growth
GO:0042493 response to drug
GO:0042593 glucose homeostasis
GO:0043231 intracellular membrane-bounded organelle
GO:0043433 negative regulation of DNA-binding transcription factor activity
GO:0043616 keratinocyte proliferation
GO:0044294 dendritic growth cone
GO:0044295 axonal growth cone
GO:0044877 protein-containing complex binding
GO:0045177 apical part of cell
GO:0045606 positive regulation of epidermal cell differentiation
GO:0045668 negative regulation of osteoblast differentiation
GO:0045879 negative regulation of smoothened signaling pathway
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048471 perinuclear region of cytoplasm
GO:0048568 embryonic organ development
GO:0048745 smooth muscle tissue development
GO:0050680 negative regulation of epithelial cell proliferation
GO:0051782 negative regulation of cell division
GO:0060037 pharyngeal system development
GO:0060170 ciliary membrane
GO:0060603 mammary gland duct morphogenesis
GO:0060644 mammary gland epithelial cell differentiation
GO:0060831 smoothened signaling pathway involved in dorsal/ventral neural tube patterning
GO:0061005 cell differentiation involved in kidney development
GO:0061053 somite development
GO:0071397 cellular response to cholesterol
GO:0071679 commissural neuron axon guidance
GO:0072203 cell proliferation involved in metanephros development
GO:0072205 metanephric collecting duct development
GO:0072659 protein localization to plasma membrane
GO:0097108 hedgehog family protein binding
GO:0097421 liver regeneration

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000731 Sterol-sensing domainDomainDomain
IPR003392 Protein patched/dispatchedFamilyFamily
IPR004766 Transmembrane receptor, patchedFamilyFamily

Diseases

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Interactions

49 interactions

InteractorPartnerSourcesPublicationsLink
PTC1_HUMANYAP1_HUMANBioGRID, MINT25283809 details
PTC1_HUMANSHH_HUMANBioGRID, DIP, HPRD, IntAct16282375 19561609 29954986 30139912 31253779 9811851 details
PTC1_HUMANAPBP2_HUMANBioGRID, IntAct32296183 details
PTC1_HUMANF209A_HUMANBioGRID, IntAct32296183 details
PTC1_HUMANMO2R1_HUMANBioGRID, IntAct32296183 details
PTC1_HUMANCD79A_HUMANBioGRID, IntAct32296183 details
PTC1_HUMANTMPS2_HUMANBioGRID, IntAct32296183 details
PTC1_HUMANSTOM_HUMANBioGRID, IntAct32296183 details
PTC1_HUMANHG2A_HUMANBioGRID, IntAct32296183 details
PTC1_HUMAN3HIDH_HUMANBioGRID, IntAct32296183 details
PTC1_HUMANSIG12_HUMANBioGRID, IntAct32296183 details
PTC1_HUMANCREB3_HUMANBioGRID, IntAct25910212 details
PTC1_HUMANHD_HUMANIntAct32814053 details
PTC1_HUMANATM_HUMANBioGRID15142440 details
PTC1_HUMANATGA1_HUMANBioGRID29453315 details
PTC1_HUMANTSN8_HUMANBioGRID31253779 details
PTC1_HUMANSMO_HUMANbhf-ucl, BioGRID, HPRD11278759 9811851 details
PTC1_HUMANARBK1_HUMANBioGRID, DIP19502428 26885983 31253779 details
PTC1_HUMANCCNB1_HUMANBioGRID, DIP, HPRD15592520 19502428 9926943 details
PTC1_HUMANCDON_HUMANIntAct21802063 details
PTC1_HUMANCAV1_HUMANBioGRID11278759 details
PTC1_HUMANITCH_HUMANBioGRID25092867 details
PTC1_HUMANWWP2_HUMANBioGRID25092867 details
PTC1_HUMANNEDD4_HUMANBioGRID25092867 details
PTC1_HUMANNED4L_HUMANBioGRID25092867 details
PTC1_HUMANSMUF1_HUMANBioGRID25092867 details
PTC1_HUMANSMUF2_HUMANBioGRID25092867 details
PTC1_HUMANWWP1_HUMANBioGRID25092867 details
PTC1_HUMANCASP9_HUMANBioGRID25092867 details
PTC1_HUMANFHL2_HUMANBioGRID25092867 details
PTC1_HUMANPRP19_HUMANBioGRID26885983 details
PTC1_HUMANPTC1_HUMANBioGRID26885983 31168089 details
PTC1_HUMANSKP1_HUMANBioGRID26885983 details
PTC1_HUMANELOC_HUMANBioGRID26885983 details
PTC1_HUMANZY11B_HUMANBioGRID26885983 details
PTC1_HUMANELOB_HUMANBioGRID26885983 details
PTC1_HUMANCUL2_HUMANBioGRID26885983 details
PTC1_HUMANCUL1_HUMANBioGRID26885983 details
PTC1_HUMANCUL3_HUMANBioGRID26885983 details
PTC1_HUMANFBW1A_HUMANBioGRID26885983 details
PTC1_HUMANRBCC1_HUMANBioGRID29453315 details
PTC1_HUMANULK1_HUMANBioGRID29453315 details
PTC1_HUMANATG13_HUMANBioGRID29453315 details
PTC1_HUMANATX3_HUMANBioGRID31253779 details
PTC1_HUMANSTAT3_HUMANBioGRID29449694 details
PTC1_HUMANIHH_HUMANHPRD9811851 details
PTC1_HUMANDHH_HUMANHPRD9811851 details
PTC1_HUMANHIPK2_HUMANHPRD12874272 details
PTC1_HUMANCDK1_HUMANHPRD11331587 details