Entity Details

Primary name PDE1C_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ14123
EntryNamePDE1C_HUMAN
FullNameCalcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C
TaxID9606
Evidenceevidence at protein level
Length709
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesPDE1C

GO terms

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GOName
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity
GO:0004117 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity
GO:0005516 calmodulin binding
GO:0005829 cytosol
GO:0007165 signal transduction
GO:0043025 neuronal cell body
GO:0046872 metal ion binding
GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity

Subcellular Location

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Domains

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DomainNameCategoryType
IPR002073 3'5'-cyclic nucleotide phosphodiesterase, catalytic domainDomainDomain
IPR003607 HD/PDEase domainDomainDomain
IPR013706 3'5'-cyclic nucleotide phosphodiesterase N-terminalDomainDomain
IPR023088 3'5'-cyclic nucleotide phosphodiesteraseFamilyFamily
IPR023174 3'5'-cyclic nucleotide phosphodiesterase, conserved siteSiteConserved site
IPR036971 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
618140 OMIMDeafness, autosomal dominant, 74 (DFNA74)A form of non-syndromic deafness characterized by progressive, postlingual hearing loss with onset in the third decade of life. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00201 CaffeineDrugbanksmall molecule
DB09283 TrapidilDrugbanksmall molecule

Interactions

0 interactions

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