Entity Details

Primary name SIRT2
Entity type gene
Source Source Link

Details

PrimaryID22933
RefseqGene
SymbolSIRT2
Namesirtuin 2
Chromosome19
Location19q13.2
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2001-03-22
ModificationDate2021-06-20

Ontological Relatives

UniProt IDsSIR2_HUMAN

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000183 rDNA heterochromatin assembly
GO:0000781 chromosome, telomeric region
GO:0000792 heterochromatin
GO:0003682 chromatin binding
GO:0003950 NAD+ ADP-ribosyltransferase activity
GO:0004407 histone deacetylase activity
GO:0005634 nucleus
GO:0005677 chromatin silencing complex
GO:0005694 chromosome
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005813 centrosome
GO:0005814 centriole
GO:0005819 spindle
GO:0005829 cytosol
GO:0005874 microtubule
GO:0005886 plasma membrane
GO:0006342 chromatin silencing
GO:0006348 chromatin silencing at telomere
GO:0006471 protein ADP-ribosylation
GO:0006476 protein deacetylation
GO:0006914 autophagy
GO:0007084 mitotic nuclear membrane reassembly
GO:0007096 regulation of exit from mitosis
GO:0008134 transcription factor binding
GO:0008270 zinc ion binding
GO:0008285 negative regulation of cell population proliferation
GO:0010507 negative regulation of autophagy
GO:0010801 negative regulation of peptidyl-threonine phosphorylation
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0016575 histone deacetylation
GO:0017136 NAD-dependent histone deacetylase activity
GO:0021762 substantia nigra development
GO:0022011 myelination in peripheral nervous system
GO:0030426 growth cone
GO:0030496 midbody
GO:0031641 regulation of myelination
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0033010 paranodal junction
GO:0033270 paranode region of axon
GO:0033558 protein deacetylase activity
GO:0034599 cellular response to oxidative stress
GO:0034979 NAD-dependent protein deacetylase activity
GO:0034983 peptidyl-lysine deacetylation
GO:0035035 histone acetyltransferase binding
GO:0035729 cellular response to hepatocyte growth factor stimulus
GO:0042177 negative regulation of protein catabolic process
GO:0042325 regulation of phosphorylation
GO:0042826 histone deacetylase binding
GO:0042903 tubulin deacetylase activity
GO:0043130 ubiquitin binding
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043204 perikaryon
GO:0043209 myelin sheath
GO:0043219 lateral loop
GO:0043220 Schmidt-Lanterman incisure
GO:0043388 positive regulation of DNA binding
GO:0043491 protein kinase B signaling
GO:0044224 juxtaparanode region of axon
GO:0044242 cellular lipid catabolic process
GO:0045087 innate immune response
GO:0045599 negative regulation of fat cell differentiation
GO:0045836 positive regulation of meiotic nuclear division
GO:0045843 negative regulation of striated muscle tissue development
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046970 NAD-dependent histone deacetylase activity (H4-K16 specific)
GO:0048012 hepatocyte growth factor receptor signaling pathway
GO:0048471 perinuclear region of cytoplasm
GO:0051301 cell division
GO:0051321 meiotic cell cycle
GO:0051726 regulation of cell cycle
GO:0051775 response to redox state
GO:0051781 positive regulation of cell division
GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore
GO:0061428 negative regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0061433 cellular response to caloric restriction
GO:0070403 NAD+ binding
GO:0070446 negative regulation of oligodendrocyte progenitor proliferation
GO:0070932 histone H3 deacetylation
GO:0070933 histone H4 deacetylation
GO:0071219 cellular response to molecule of bacterial origin
GO:0071456 cellular response to hypoxia
GO:0071872 cellular response to epinephrine stimulus
GO:0072686 mitotic spindle
GO:0072687 meiotic spindle
GO:0090042 tubulin deacetylation
GO:0097386 glial cell projection
GO:1900119 positive regulation of execution phase of apoptosis
GO:1900195 positive regulation of oocyte maturation
GO:1900226 negative regulation of NLRP3 inflammasome complex assembly
GO:1900425 negative regulation of defense response to bacterium
GO:2000378 negative regulation of reactive oxygen species metabolic process
GO:2000777 positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia

Diseases

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Interactions

130 interactions

InteractorPartnerSourcesPublicationsLink
SIRT2FZR1BioGRID, IntAct22014574 details
SIRT2CDC20BioGRID, IntAct22014574 details
SIRT2RAD51BioGRID, MINT25640309 details
SIRT2RELAIntAct21081649 details
SIRT2OXTRBioGRID, MINT28298427 details
SIRT2H3C1BioGRID19270680 19801601 details
SIRT2EP300BioGRID18722353 18995842 23934153 details
SIRT2FOXO1BioGRID15220471 20543840 24419059 details
SIRT2XPO1BioGRID22833565 26673895 details
SIRT2TUBA4ABioGRID, HPRD12620231 details
SIRT2MDM2BioGRID28196907 details
SIRT2PLA2G4ABioGRID26303530 details
SIRT2CDK2BioGRID26303530 details
SIRT2ARHGDIABioGRID26719334 details
SIRT2HIF1ABioGRID24681946 details
SIRT2PHGDHBioGRID32783943 details
SIRT2HOXA10HPRD15213244 details
SIRT2KAT2BBioGRID, HPRD, IntAct12887892 30482390 details
SIRT2KAT2AHPRD, IntAct12887892 details
SIRT2HDAC6BioGRID, HPRD, IntAct12620231 17516032 details
SIRT2SPOPBioGRID, IntAct17353931 28073696 details
SIRT2CDC14BHPRD, MINT12697818 details
SIRT2MYCIntAct23217706 details
SIRT2G6PDMINT24769394 details
SIRT2BUB1BMINT24825348 details
SIRT2H4-16IntAct21081649 details
SIRT2H4C15IntAct21081649 details
SIRT2H4C9IntAct21081649 details
SIRT2H4C1IntAct21081649 details
SIRT2H4C4IntAct21081649 details
SIRT2H4C6IntAct21081649 details
SIRT2H4C12IntAct21081649 details
SIRT2H4C11IntAct21081649 details
SIRT2H4C3IntAct21081649 details
SIRT2H4C8IntAct21081649 details
SIRT2H4C2IntAct21081649 details
SIRT2H4C5IntAct21081649 details
SIRT2H4C13IntAct21081649 details
SIRT2H4C14IntAct21081649 details
SIRT2DNAJB6BioGRID20159555 details
SIRT2DNAJB8BioGRID20159555 details
SIRT2NUDT21BioGRID17172643 details
SIRT2PAPOLABioGRID17172643 details
SIRT2ING1BioGRID14522900 details
SIRT2RBP1BioGRID18193082 details
SIRT2SIRT1BioGRID18193082 details
SIRT2PCK1BioGRID21726808 details
SIRT2RUNX3BioGRID21511279 details
SIRT2CBLBBioGRID25285640 details
SIRT2CBLBioGRID25285640 details
SIRT2ACLYBioGRID23932781 details
SIRT2GCKRBioGRID26620281 details
SIRT2SKP2BioGRID26942878 details
SIRT2UNKBioGRID29395067 details
SIRT2ENTR1BioGRID29395067 details
SIRT2TBK1BioGRID29395067 details
SIRT2SYVN1BioGRID31932479 details
SIRT2SP140HPRD12887892 details
SIRT2MYOD1IntAct12887892 details
SIRT2SARS1BioGRID, IntAct17353931 26186194 28514442 details
SIRT2PHB2BioGRID, IntAct17353931 details
SIRT2GYS1BioGRID, IntAct17353931 details
SIRT2KRT78BioGRID, IntAct17353931 details
SIRT2RTN4BioGRID, IntAct17353931 details
SIRT2CDC27IntAct22014574 details
SIRT2PPP1CBBioGRID, IntAct26496610 details
SIRT2AHI1BioGRID, IntAct26638075 details
SIRT2FBF1BioGRID, IntAct26638075 details
SIRT2CEP89BioGRID, IntAct26638075 details
SIRT2ODF2BioGRID, IntAct26638075 details
SIRT2RPGRIP1LBioGRID, IntAct26638075 details
SIRT2SCLT1BioGRID, IntAct26638075 details
SIRT2NUDT12BioGRID, IntAct26186194 28514442 details
SIRT2MANSC1BioGRID, IntAct28514442 details
SIRT2GPAMBioGRID, IntAct26186194 28514442 details
SIRT2RAB3GAP2BioGRID, IntAct26186194 28514442 details
SIRT2SCFD2BioGRID, IntAct26186194 28514442 details
SIRT2MTDHBioGRID, IntAct26186194 28514442 details
SIRT2RAB3GAP1BioGRID, IntAct26186194 28514442 details
SIRT2ORC2BioGRID, IntAct26186194 28514442 details
SIRT2VAMP7BioGRID, IntAct26186194 28514442 details
SIRT2FADS1BioGRID, IntAct26186194 28514442 details
SIRT2DEGS1BioGRID, IntAct26186194 28514442 details
SIRT2GSTT1BioGRID, IntAct28514442 details
SIRT2DMDBioGRID, IntAct28514442 details
SIRT2KIAA0930BioGRID, IntAct28514442 details
SIRT2SNAI1BioGRID, IntAct26186194 28514442 details
SIRT2SLC22A23BioGRID, IntAct28514442 details
SIRT2MOAP1BioGRID, IntAct28514442 details
SIRT2GSTT2BBioGRID, IntAct28514442 details
SIRT2EZRBioGRID, IntAct29568061 details
SIRT2MAPTUniProt26402096 details
SIRT2GARTBioGRID, MINT24981860 details
SIRT2ELLBioGRID17353931 details
SIRT2TRAPPC12BioGRID26186194 details
SIRT2BTRCBioGRID25900982 details
SIRT2TINF2BioGRID26496610 details
SIRT2RIOK1BioGRID21081503 details
SIRT2OTULINLBioGRID31056421 details
SIRT2IMMP2LBioGRID31617661 details
SIRT2FBXL4BioGRID32877691 details
SIRT2MTCH2BioGRID32877691 details
SIRT2OCIAD1BioGRID32877691 details
SIRT2RMDN3BioGRID32877691 details
SIRT2CUL4ABioGRID32235678 details
SIRT2ACTR2BioGRID34079125 details
SIRT2AGPSBioGRID34079125 details
SIRT2ANAPC2BioGRID34079125 details
SIRT2ANK3BioGRID34079125 details
SIRT2BORCS6BioGRID34079125 details
SIRT2C11orf52BioGRID34079125 details
SIRT2CLIP1BioGRID34079125 details
SIRT2CTNNA1BioGRID34079125 details
SIRT2DCTN2BioGRID34079125 details
SIRT2DERL1BioGRID34079125 details
SIRT2DYNC1I2BioGRID34079125 details
SIRT2EBAG9BioGRID34079125 details
SIRT2GFAPBioGRID34079125 details
SIRT2HSD17B11BioGRID34079125 details
SIRT2KRT19BioGRID34079125 details
SIRT2KRT8BioGRID34079125 details
SIRT2LAMTOR1BioGRID34079125 details
SIRT2MARCKSBioGRID34079125 details
SIRT2PANX1BioGRID34079125 details
SIRT2PRPHBioGRID34079125 details
SIRT2REEP5BioGRID34079125 details
SIRT2SEPTIN10BioGRID34079125 details
SIRT2SQSTM1BioGRID34079125 details
SIRT2STIM1BioGRID34079125 details
SIRT2UTP4BioGRID34079125 details