Entity Details

Primary name FAK2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ14289
EntryNameFAK2_HUMAN
FullNameProtein-tyrosine kinase 2-beta
TaxID9606
Evidenceevidence at protein level
Length1009
SequenceStatuscomplete
DateCreated1998-07-15
DateModified2021-06-02

Ontological Relatives

GenesPTK2B

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0001525 angiogenesis
GO:0001556 oocyte maturation
GO:0001666 response to hypoxia
GO:0001954 positive regulation of cell-matrix adhesion
GO:0002040 sprouting angiogenesis
GO:0002250 adaptive immune response
GO:0002315 marginal zone B cell differentiation
GO:0004683 calmodulin-dependent protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0004972 NMDA glutamate receptor activity
GO:0005102 signaling receptor binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005925 focal adhesion
GO:0005938 cell cortex
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0006968 cellular defense response
GO:0006970 response to osmotic stress
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007172 signal complex assembly
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007229 integrin-mediated signaling pathway
GO:0008022 protein C-terminus binding
GO:0008284 positive regulation of cell population proliferation
GO:0008285 negative regulation of cell population proliferation
GO:0008360 regulation of cell shape
GO:0009612 response to mechanical stimulus
GO:0009725 response to hormone
GO:0009749 response to glucose
GO:0010226 response to lithium ion
GO:0010595 positive regulation of endothelial cell migration
GO:0010656 negative regulation of muscle cell apoptotic process
GO:0010752 regulation of cGMP-mediated signaling
GO:0010758 regulation of macrophage chemotaxis
GO:0010976 positive regulation of neuron projection development
GO:0014009 glial cell proliferation
GO:0014069 postsynaptic density
GO:0017146 NMDA selective glutamate receptor complex
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0030027 lamellipodium
GO:0030154 cell differentiation
GO:0030155 regulation of cell adhesion
GO:0030307 positive regulation of cell growth
GO:0030335 positive regulation of cell migration
GO:0030425 dendrite
GO:0030426 growth cone
GO:0030502 negative regulation of bone mineralization
GO:0030838 positive regulation of actin filament polymerization
GO:0031175 neuron projection development
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0031625 ubiquitin protein ligase binding
GO:0032960 regulation of inositol trisphosphate biosynthetic process
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0035235 ionotropic glutamate receptor signaling pathway
GO:0035902 response to immobilization stress
GO:0038083 peptidyl-tyrosine autophosphorylation
GO:0038110 interleukin-2-mediated signaling pathway
GO:0042220 response to cocaine
GO:0042493 response to drug
GO:0042542 response to hydrogen peroxide
GO:0042976 activation of Janus kinase activity
GO:0043025 neuronal cell body
GO:0043066 negative regulation of apoptotic process
GO:0043149 stress fiber assembly
GO:0043197 dendritic spine
GO:0043267 negative regulation of potassium ion transport
GO:0043423 3-phosphoinositide-dependent protein kinase binding
GO:0043507 positive regulation of JUN kinase activity
GO:0043524 negative regulation of neuron apoptotic process
GO:0043534 blood vessel endothelial cell migration
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0044297 cell body
GO:0044877 protein-containing complex binding
GO:0045087 innate immune response
GO:0045121 membrane raft
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045453 bone resorption
GO:0045471 response to ethanol
GO:0045638 negative regulation of myeloid cell differentiation
GO:0045727 positive regulation of translation
GO:0045766 positive regulation of angiogenesis
GO:0045860 positive regulation of protein kinase activity
GO:0046330 positive regulation of JNK cascade
GO:0046777 protein autophosphorylation
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048041 focal adhesion assembly
GO:0048167 regulation of synaptic plasticity
GO:0048471 perinuclear region of cytoplasm
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050848 regulation of calcium-mediated signaling
GO:0051000 positive regulation of nitric-oxide synthase activity
GO:0051279 regulation of release of sequestered calcium ion into cytosol
GO:0051591 response to cAMP
GO:0051592 response to calcium ion
GO:0051968 positive regulation of synaptic transmission, glutamatergic
GO:0060291 long-term synaptic potentiation
GO:0060292 long-term synaptic depression
GO:0065003 protein-containing complex assembly
GO:0070098 chemokine-mediated signaling pathway
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071300 cellular response to retinoic acid
GO:0071498 cellular response to fluid shear stress
GO:0086100 endothelin receptor signaling pathway
GO:0090630 activation of GTPase activity
GO:0097440 apical dendrite
GO:0098978 glutamatergic synapse
GO:2000058 regulation of ubiquitin-dependent protein catabolic process
GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process
GO:2000114 regulation of establishment of cell polarity
GO:2000249 regulation of actin cytoskeleton reorganization
GO:2000310 regulation of NMDA receptor activity
GO:2000379 positive regulation of reactive oxygen species metabolic process
GO:2000463 positive regulation of excitatory postsynaptic potential
GO:2000538 positive regulation of B cell chemotaxis
GO:2000573 positive regulation of DNA biosynthetic process

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Cell projection
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000299 FERM domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR005189 Focal adhesion kinase, targeting (FAT) domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR014352 FERM/acyl-CoA-binding protein superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR019748 FERM central domainDomainDomain
IPR019749 Band 4.1 domainDomainDomain
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR029071 Ubiquitin-like domain superfamilyFamilyHomologous superfamily
IPR030610 Protein-tyrosine kinase 2-betaFamilyFamily
IPR035963 FERM superfamily, second domainFamilyHomologous superfamily
IPR036137 Focal adhesion kinase, targeting (FAT) domain superfamilyFamilyHomologous superfamily
IPR041390 Focal adhesion kinase, N-terminalDomainDomain
IPR041784 FAK1/PYK2, FERM domain C-lobeDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB01097 LeflunomideDrugbanksmall molecule
DB01645 GenisteinDrugbanksmall molecule
DB08341 4-{[4-{[(1R,2R)-2-(dimethylamino)cyclopentyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-N-methylbenzenesulfonamideDrugbanksmall molecule
DB11817 BaricitinibDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule

Interactions

96 interactions

InteractorPartnerSourcesPublicationsLink
FAK2_HUMANRHOU_HUMANIntAct18086875 details
FAK2_HUMANSRC_HUMANBioGRID, HPRD, MINT10521452 10777553 11149930 19380485 8849729 details
FAK2_HUMANFYN_HUMANBioGRID, HPRD, IntAct, MINT10229084 10867021 31413325 9091579 9104812 details
FAK2_HUMANNPHP1_HUMANBioGRID, HPRD, IntAct11493697 21357692 details
FAK2_HUMANSKAP2_HUMANBioGRID, IntAct12893833 31413325 details
FAK2_HUMANTGFI1_HUMANBioGRID, HPRD, IntAct11856738 11937718 16330715 9422762 9858471 details
FAK2_HUMANPAXI_HUMANBioGRID, HPRD, IntAct10980697 11036077 31980649 9099734 9422762 details
FAK2_HUMANA4_HUMANIntAct32814053 details
FAK2_HUMANSRBS2_HUMANBioGRID, HPRD15128873 details
FAK2_HUMANGELS_HUMANBioGRID, HPRD12578912 details
FAK2_HUMANDLG3_HUMANBioGRID, HPRD12576483 details
FAK2_HUMANDLG4_HUMANBioGRID, HPRD12576483 details
FAK2_HUMANPTN6_HUMANBioGRID, HPRD10521452 10747947 details
FAK2_HUMANFAK2_HUMANBioGRID, HPRD11337490 11493697 17192257 9512511 9560226 details
FAK2_HUMANBCAR1_HUMANBioGRID, HPRD11036077 12893833 8995252 9020138 details
FAK2_HUMANPITM3_HUMANBioGRID, HPRD10022914 details
FAK2_HUMANPITM1_HUMANBioGRID, HPRD10022914 details
FAK2_HUMANPITM2_HUMANBioGRID, HPRD10022914 details
FAK2_HUMANASAP2_HUMANBioGRID, HPRD10022920 details
FAK2_HUMANPTN12_HUMANBioGRID, HPRD11337490 12231407 15588985 details
FAK2_HUMANITB3_HUMANBioGRID, HPRD11683411 details
FAK2_HUMANPTN11_HUMANBioGRID, HPRD10880513 details
FAK2_HUMANRBCC1_HUMANBioGRID, HPRD10769033 details
FAK2_HUMANEWS_HUMANBioGRID, HPRD10322114 details
FAK2_HUMANVAV_HUMANBioGRID, HPRD10867021 details
FAK2_HUMANRASA1_HUMANBioGRID, HPRD10708762 10713673 details
FAK2_HUMANSOCS3_HUMANBioGRID18507841 9344848 details
FAK2_HUMANMBD2_HUMANBioGRID19661918 details
FAK2_HUMANSOCS2_HUMANBioGRID20543098 details
FAK2_HUMANTAU_HUMANBioGRID17512525 details
FAK2_HUMANRHG21_HUMANHPRD11238453 details
FAK2_HUMANASAP1_HUMANHPRD12771146 details
FAK2_HUMANM3K4_HUMANHPRD, MINT15601262 15881658 details
FAK2_HUMANPDC6I_HUMANBioGRID, HPRD, MINT12771190 15557335 details
FAK2_HUMANEGFR_HUMANBioGRID, HPRD, IntAct10777553 10980697 15657067 details
FAK2_HUMANMATK_HUMANHPRD, MINT12063569 details
FAK2_HUMANGRB2_HUMANBioGRID, HPRD, MINT10329689 10354709 19380485 8695788 details
FAK2_HUMANMYD88_HUMANInnateDB22581261 details
FAK2_HUMANHS90B_HUMANIntAct22939624 details
FAK2_HUMANERBB2_HUMANBioGRID, HPRD, IntAct10713673 25241761 details
FAK2_HUMANNPHP4_HUMANUniProt15661758 details
FAK2_HUMANCLH1_HUMANIntAct31413325 details
FAK2_HUMANCASS4_HUMANIntAct31413325 details
FAK2_HUMANPHLP1_HUMANIntAct31413325 details
FAK2_HUMANEXC6B_HUMANIntAct31413325 details
FAK2_HUMANMUC18_HUMANHPRD, IntAct11036077 31413325 details
FAK2_HUMANPAX6_HUMANIntAct31413325 details
FAK2_HUMANKCC2A_HUMANIntAct31413325 details
FAK2_HUMANLPXN_HUMANBioGRID, HPRD, IntAct31413325 9565592 details
FAK2_HUMANTRAF4_HUMANBioGRID, IntAct16330715 20946164 details
FAK2_HUMANNCF1_HUMANBioGRID, IntAct16330715 details
FAK2_HUMANCBL_HUMANBioGRID, HPRD11149930 12771190 15128873 details
FAK2_HUMANGIT1_HUMANBioGRID12629171 details
FAK2_HUMANNMDE1_HUMANBioGRID, HPRD11478920 12576483 details
FAK2_HUMANKSYK_HUMANBioGRID, HPRD10747947 details
FAK2_HUMANLCK_HUMANBioGRID, HPRD9091579 details
FAK2_HUMANJAK3_HUMANBioGRID, HPRD9512511 details
FAK2_HUMANJAK1_HUMANBioGRID, HPRD10702271 details
FAK2_HUMANIL7RA_HUMANBioGRID, HPRD10702271 details
FAK2_HUMANKCNA2_HUMANBioGRID, HPRD11739373 details
FAK2_HUMANLYN_HUMANBioGRID, HPRD11311138 details
FAK2_HUMANCASL_HUMANBioGRID, HPRD9020138 details
FAK2_HUMANJAK2_HUMANBioGRID, HPRD11818507 details
FAK2_HUMANGTR1_HUMANBioGRID, HPRD11007796 details
FAK2_HUMANKPCD_HUMANBioGRID, HPRD11352632 details
FAK2_HUMANGNA13_HUMANBioGRID, HPRD10821841 details
FAK2_HUMANITB2_HUMANBioGRID, HPRD10961871 details
FAK2_HUMANTLN1_HUMANBioGRID, HPRD9442086 details
FAK2_HUMANPTEN_HUMANBioGRID15717329 details
FAK2_HUMANSH3K1_HUMANBioGRID12771190 details
FAK2_HUMANALG2_HUMANBioGRID12771190 details
FAK2_HUMANDYN1_HUMANBioGRID19380485 details
FAK2_HUMANGPVI_HUMANBioGRID20946164 details
FAK2_HUMANGP1BB_HUMANBioGRID20946164 details
FAK2_HUMANCBLB_HUMANBioGRID25099615 details
FAK2_HUMANERBB3_HUMANBioGRID, HPRD15499613 27793840 details
FAK2_HUMANNED4L_HUMANBioGRID27793840 details
FAK2_HUMANNEDD4_HUMANBioGRID27793840 details
FAK2_HUMANP85A_HUMANBioGRID, HPRD10797305 15539082 details
FAK2_HUMANITB1_HUMANBioGRID15539082 details
FAK2_HUMANGRM1_HUMANBioGRID20180987 details
FAK2_HUMANZAP70_HUMANHPRD10867021 details
FAK2_HUMANSHC1_HUMANHPRD7544443 details
FAK2_HUMANCCR5_HUMANHPRD9446638 details
FAK2_HUMANEFS_HUMANHPRD9750131 details
FAK2_HUMANRHG05_HUMANHPRD10713673 details
FAK2_HUMANFGFR3_HUMANHPRD15105428 details
FAK2_HUMANVGFR1_HUMANHPRD11751905 details
FAK2_HUMANPDPK1_HUMANHPRD14585963 details
FAK2_HUMANSTAT3_HUMANHPRD14963038 details
FAK2_HUMANSH2D3_HUMANHPRD12486027 details
FAK2_HUMANSTAP1_HUMANHPRD10518561 details
FAK2_HUMANDLGP3_HUMANHPRD16202977 details
FAK2_HUMANMYH2_HUMANHPRD10082674 details
FAK2_HUMANSYUA_HUMANHPRD11162638 11744621 12096713 details
FAK2_HUMANCRK_HUMANHPRD10329689 details