Entity Details

Primary name HES1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ14469
EntryNameHES1_HUMAN
FullNameTranscription factor HES-1
TaxID9606
Evidenceevidence at protein level
Length280
SequenceStatuscomplete
DateCreated1998-12-15
DateModified2021-06-02

Ontological Relatives

GenesHES1

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001889 liver development
GO:0003143 embryonic heart tube morphogenesis
GO:0003151 outflow tract morphogenesis
GO:0003266 regulation of secondary heart field cardioblast proliferation
GO:0003281 ventricular septum development
GO:0003677 DNA binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007155 cell adhesion
GO:0007219 Notch signaling pathway
GO:0007224 smoothened signaling pathway
GO:0007399 nervous system development
GO:0008134 transcription factor binding
GO:0008284 positive regulation of cell population proliferation
GO:0009952 anterior/posterior pattern specification
GO:0016477 cell migration
GO:0021537 telencephalon development
GO:0021555 midbrain-hindbrain boundary morphogenesis
GO:0021557 oculomotor nerve development
GO:0021558 trochlear nerve development
GO:0021575 hindbrain morphogenesis
GO:0021861 forebrain radial glial cell differentiation
GO:0021984 adenohypophysis development
GO:0030324 lung development
GO:0030513 positive regulation of BMP signaling pathway
GO:0030901 midbrain development
GO:0031016 pancreas development
GO:0032991 protein-containing complex
GO:0035019 somatic stem cell population maintenance
GO:0035910 ascending aorta morphogenesis
GO:0042102 positive regulation of T cell proliferation
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0042803 protein homodimerization activity
GO:0042826 histone deacetylase binding
GO:0043388 positive regulation of DNA binding
GO:0043398 HLH domain binding
GO:0043433 negative regulation of DNA-binding transcription factor activity
GO:0043565 sequence-specific DNA binding
GO:0045598 regulation of fat cell differentiation
GO:0045608 negative regulation of inner ear auditory receptor cell differentiation
GO:0045665 negative regulation of neuron differentiation
GO:0045747 positive regulation of Notch signaling pathway
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0045977 positive regulation of mitotic cell cycle, embryonic
GO:0046331 lateral inhibition
GO:0046425 regulation of receptor signaling pathway via JAK-STAT
GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT
GO:0048469 cell maturation
GO:0048538 thymus development
GO:0048667 cell morphogenesis involved in neuron differentiation
GO:0048711 positive regulation of astrocyte differentiation
GO:0048715 negative regulation of oligodendrocyte differentiation
GO:0048844 artery morphogenesis
GO:0050678 regulation of epithelial cell proliferation
GO:0050767 regulation of neurogenesis
GO:0051087 chaperone binding
GO:0060122 inner ear receptor cell stereocilium organization
GO:0060164 regulation of timing of neuron differentiation
GO:0060253 negative regulation of glial cell proliferation
GO:0060412 ventricular septum morphogenesis
GO:0060675 ureteric bud morphogenesis
GO:0060716 labyrinthine layer blood vessel development
GO:0061009 common bile duct development
GO:0061106 negative regulation of stomach neuroendocrine cell differentiation
GO:0061309 cardiac neural crest cell development involved in outflow tract morphogenesis
GO:0061626 pharyngeal arch artery morphogenesis
GO:0065003 protein-containing complex assembly
GO:0070888 E-box binding
GO:0071820 N-box binding
GO:0072012 glomerulus vasculature development
GO:0072049 comma-shaped body morphogenesis
GO:0072050 S-shaped body morphogenesis
GO:0072141 renal interstitial fibroblast development
GO:0072282 metanephric nephron tubule morphogenesis
GO:0090102 cochlea development
GO:0090162 establishment of epithelial cell polarity
GO:0097084 vascular associated smooth muscle cell development
GO:0097150 neuronal stem cell population maintenance
GO:1905934 negative regulation of cell fate determination
GO:1990837 sequence-specific double-stranded DNA binding
GO:2000227 negative regulation of pancreatic A cell differentiation
GO:2000737 negative regulation of stem cell differentiation
GO:2000974 negative regulation of pro-B cell differentiation
GO:2000978 negative regulation of forebrain neuron differentiation

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR003650 Orange domainDomainDomain
IPR011598 Myc-type, basic helix-loop-helix (bHLH) domainDomainDomain
IPR036638 Helix-loop-helix DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

48 interactions

InteractorPartnerSourcesPublicationsLink
HES1_HUMANASGR2_HUMANBioGRID, IntAct21988832 details
HES1_HUMANTNR3_HUMANBioGRID, IntAct21988832 details
HES1_HUMANAPH1A_HUMANBioGRID, IntAct21988832 details
HES1_HUMANSIR1_HUMANBioGRID, HPRD, UniProt12535671 details
HES1_HUMANSAMP_HUMANBioGRID, MINT21900206 details
HES1_HUMANKC1E_HUMANBioGRID, MINT21900206 details
HES1_HUMANFHL1_HUMANBioGRID, MINT21900206 details
HES1_HUMANG3P_HUMANBioGRID, MINT21900206 details
HES1_HUMANHDAC6_HUMANBioGRID, MINT21900206 details
HES1_HUMANHMGCL_HUMANBioGRID, MINT21900206 details
HES1_HUMANNR4A1_HUMANBioGRID, MINT21900206 details
HES1_HUMANNUDT3_HUMANBioGRID, MINT21900206 details
HES1_HUMANFAK1_HUMANBioGRID, MINT21900206 details
HES1_HUMAN1433B_HUMANBioGRID, MINT21900206 details
HES1_HUMANHEY2_HUMANBioGRID, HPRD11486045 details
HES1_HUMANTLE2_HUMANBioGRID9874198 details
HES1_HUMANFANCF_HUMANBioGRID, HPRD18550849 19321451 details
HES1_HUMANFANCG_HUMANBioGRID, HPRD18550849 19321451 details
HES1_HUMANFANCL_HUMANBioGRID, HPRD18550849 details
HES1_HUMANFANCA_HUMANBioGRID, HPRD18550849 19321451 details
HES1_HUMANFANCE_HUMANBioGRID, HPRD18550849 19321451 26277624 details
HES1_HUMANTLE1_HUMANBioGRID, HPRD18611861 19321451 8687460 details
HES1_HUMANSTAT3_HUMANBioGRID, HPRD15156153 details
HES1_HUMANHEY1_HUMANBioGRID19802006 26068074 27129302 details
HES1_HUMANHEN2_HUMANBioGRID21573214 details
HES1_HUMANUBQL1_HUMANHPRD15492808 details
HES1_HUMANID3_HUMANHPRD11756408 details
HES1_HUMANID2_HUMANHPRD11756408 details
HES1_HUMANID1_HUMANHPRD11756408 details
HES1_HUMANID4_HUMANHPRD11756408 details
HES1_HUMANRUNX2_HUMANBioGRID16195230 details
HES1_HUMANHDAC1_HUMANBioGRID16195230 details
HES1_HUMANFANCC_HUMANBioGRID18550849 details
HES1_HUMANHSP74_HUMANBioGRID18550849 details
HES1_HUMANHS90A_HUMANBioGRID18550849 details
HES1_HUMANSPTN1_HUMANBioGRID18550849 details
HES1_HUMANPARP1_HUMANBioGRID21224467 details
HES1_HUMANJAK2_HUMANBioGRID, HPRD15156153 details
HES1_HUMANHES1_HUMANBioGRID19321451 details
HES1_HUMANLMO3_HUMANBioGRID21573214 details
HES1_HUMANCUL1_HUMANBioGRID29070679 details
HES1_HUMANSKP1_HUMANBioGRID29070679 details
HES1_HUMANFXL14_HUMANBioGRID29070679 details
HES1_HUMANUBC_HUMANBioGRID29463306 details
HES1_HUMANHMGB1_HUMANHPRD11748221 details
HES1_HUMANFOXG1_HUMANHPRD11238932 details
HES1_HUMANKPCA_HUMANHPRD9389649 details
HES1_HUMANHES6_HUMANHPRD10851137 details