Entity Details

Primary name ITPR2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ14571
EntryNameITPR2_HUMAN
FullNameInositol 1,4,5-trisphosphate receptor type 2
TaxID9606
Evidenceevidence at protein level
Length2701
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesITPR2

GO terms

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GOName
GO:0001666 response to hypoxia
GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
GO:0005509 calcium ion binding
GO:0005654 nucleoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0005938 cell cortex
GO:0007165 signal transduction
GO:0015085 calcium ion transmembrane transporter activity
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016529 sarcoplasmic reticulum
GO:0030168 platelet activation
GO:0030659 cytoplasmic vesicle membrane
GO:0030667 secretory granule membrane
GO:0031095 platelet dense tubular network membrane
GO:0033017 sarcoplasmic reticulum membrane
GO:0035091 phosphatidylinositol binding
GO:0043235 receptor complex
GO:0044325 transmembrane transporter binding
GO:0050796 regulation of insulin secretion
GO:0051209 release of sequestered calcium ion into cytosol
GO:0070679 inositol 1,4,5 trisphosphate binding
GO:0071320 cellular response to cAMP
GO:0071361 cellular response to ethanol
GO:0097110 scaffold protein binding
GO:1903779 regulation of cardiac conduction

Subcellular Location

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Subcellular Location
Endoplasmic reticulum membrane

Domains

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DomainNameCategoryType
IPR000493 Inositol 1,4,5-trisphosphate receptorFamilyFamily
IPR000699 RIH domainDomainDomain
IPR005821 Ion transport domainDomainDomain
IPR013662 RyR/IP3R Homology associated domainDomainDomain
IPR014821 Inositol 1,4,5-trisphosphate/ryanodine receptorDomainDomain
IPR016024 Armadillo-type foldFamilyHomologous superfamily
IPR016093 MIR motifDomainDomain
IPR035910 RyR/IP3 receptor binding core, RIH domain superfamilyFamilyHomologous superfamily
IPR036300 Mir domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00201 CaffeineDrugbanksmall molecule