Entity Details

Primary name MSH6
Entity type gene
Source Source Link

Details

PrimaryID2956
RefseqGeneNG_007111
SymbolMSH6
NamemutS homolog 6
Chromosome2
Location2p16.3
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1999-09-16
ModificationDate2021-06-22

Ontological Relatives

UniProt IDsMSH6_HUMAN

GO terms

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GOName
GO:0000710 meiotic mismatch repair
GO:0000785 chromatin
GO:0003682 chromatin binding
GO:0003684 damaged DNA binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0006281 DNA repair
GO:0006290 pyrimidine dimer repair
GO:0006298 mismatch repair
GO:0008094 ATPase, acting on DNA
GO:0008340 determination of adult lifespan
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0009411 response to UV
GO:0016032 viral process
GO:0016446 somatic hypermutation of immunoglobulin genes
GO:0016447 somatic recombination of immunoglobulin gene segments
GO:0019899 enzyme binding
GO:0030983 mismatched DNA binding
GO:0032137 guanine/thymine mispair binding
GO:0032300 mismatch repair complex
GO:0032301 MutSalpha complex
GO:0035064 methylated histone binding
GO:0036297 interstrand cross-link repair
GO:0043231 intracellular membrane-bounded organelle
GO:0045190 isotype switching
GO:0045910 negative regulation of DNA recombination
GO:0051096 positive regulation of helicase activity
GO:0097193 intrinsic apoptotic signaling pathway

Diseases

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Interactions

181 interactions

InteractorPartnerSourcesPublicationsLink
MSH6MSH2BioGRID, DIP, HPRD, IntAct10029069 10748159 10783165 10856833 14657349 15064730 19377479 22939629 25241761 26344197 26496610 8942985 9428522 9774676 details
MSH6CSNK2A1BioGRID, IntAct22113938 details
MSH6HRASBioGRID, MINT24412244 details
MSH6MAP2K1BioGRID, MINT24412244 details
MSH6NANSBioGRID, MINT24412244 details
MSH6PCNABioGRID, HPRD, IntAct11005803 11274057 12171929 15225546 21725088 22232658 22939629 24958773 26344197 26496610 details
MSH6H3C1BioGRID, IntAct26912663 29568061 details
MSH6BRCA1BioGRID10783165 11498787 25184681 details
MSH6BARD1BioGRID11498787 16391231 details
MSH6SMC1ABioGRID14657349 details
MSH6CHAF1ABioGRID22232658 details
MSH6XRCC6BioGRID21075794 22863883 30585729 details
MSH6HUS1BioGRID20188637 details
MSH6RAD1BioGRID20188637 details
MSH6RAD9ABioGRID20188637 details
MSH6MUTYHBioGRID, HPRD11801590 details
MSH6PTENBioGRID31685992 details
MSH6SUMO2BioGRID32786267 details
MSH6MCCIntAct17353931 details
MSH6PSMD4MINT16990800 details
MSH6BLMBioGRID10783165 15064730 details
MSH6ATMBioGRID10783165 details
MSH6MLH1BioGRID10748159 10783165 12799449 30770470 details
MSH6MRE11BioGRID10783165 details
MSH6NBNBioGRID10783165 details
MSH6RAD50BioGRID10783165 details
MSH6RFC1BioGRID10783165 details
MSH6PMS2BioGRID10748159 12799449 17148452 details
MSH6AIREBioGRID20085707 details
MSH6ATRBioGRID20029092 details
MSH6TOPBP1BioGRID20029092 details
MSH6CLSPNBioGRID20029092 details
MSH6CHEK1BioGRID20029092 details
MSH6PRKCZBioGRID15808853 details
MSH6MORF4L1BioGRID19553677 details
MSH6EP300BioGRID, HPRD16051665 details
MSH6CREBBPBioGRID, HPRD16051665 details
MSH6DTLBioGRID21725088 details
MSH6SMARCAD1BioGRID21549307 details
MSH6PMS1BioGRID10748159 details
MSH6TP53BioGRID15064730 details
MSH6RAD51BioGRID15064730 details
MSH6XRCC5BioGRID21075794 details
MSH6PRKDCBioGRID21075794 details
MSH6SLX4BioGRID22902628 31495888 details
MSH6SIRT6BioGRID24169447 details
MSH6RNF126BioGRID26508657 details
MSH6NCLBioGRID27049334 details
MSH6HDAC6BioGRID24882211 details
MSH6MCM9BioGRID26300262 26870752 details
MSH6H2AXBioGRID26095369 28242625 details
MSH6TRIM29BioGRID26095369 details
MSH6MED9IntAct15175163 details
MSH6MYCBioGRID, IntAct17314511 17353931 29467282 details
MSH6CASP4BioGRID, IntAct17353931 details
MSH6SNW1BioGRID, MINT20467437 details
MSH6CDC5LBioGRID, MINT20467437 details
MSH6MAP1LC3AIntAct20562859 details
MSH6GABARAPIntAct20562859 details
MSH6PTBP3MINT22575643 details
MSH6E2F3MINT22157815 details
MSH6KANK2UniProt22371500 details
MSH6CUL3BioGRID, IntAct21145461 details
MSH6HDAC11BioGRID, IntAct23752268 details
MSH6YY1MINT23531880 details
MSH6STK4IntAct23386615 details
MSH6IFI16BioGRID, IntAct25665578 details
MSH6AIM2BioGRID, IntAct25665578 details
MSH6CHD8BioGRID, IntAct26496610 details
MSH6AKR7A2BioGRID, IntAct26496610 details
MSH6BRINP1BioGRID, IntAct26496610 details
MSH6STX3BioGRID, IntAct26496610 details
MSH6RUSC2BioGRID, IntAct26496610 details
MSH6KIAA1191BioGRID, IntAct26496610 details
MSH6DECR1BioGRID, IntAct26496610 details
MSH6CEP19BioGRID, IntAct26638075 details
MSH6ANGMINT28777577 details
MSH6RRP1BIntAct20926688 details
MSH6NUDCD1MINT29021621 details
MSH6H3C4IntAct29568061 details
MSH6H3C3IntAct29568061 details
MSH6H3C6IntAct29568061 details
MSH6H3C11IntAct29568061 details
MSH6H3C8IntAct29568061 details
MSH6H3C12IntAct29568061 details
MSH6H3C10IntAct29568061 details
MSH6H3C2IntAct29568061 details
MSH6H3C7IntAct29568061 details
MSH6METTL3BioGRID, UniProt29507755 details
MSH6H2AZ1BioGRID, DIP24463511 28242625 details
MSH6ANP32EDIP24463511 details
MSH6LRRK2IntAct31046837 details
MSH6P2RY6BioGRID, IntAct30833792 details
MSH6TNFSF13BBioGRID, IntAct30833792 details
MSH6UNC93B1BioGRID, IntAct30833792 details
MSH6ESR1BioGRID, IntAct31527615 details
MSH6ZDHHC5UniProt31402609 details
MSH6RIN3BioGRID, IntAct32552912 details
MSH6SIRT7BioGRID22586326 details
MSH6FBXO25BioGRID20473970 details
MSH6MSH3BioGRID22939629 details
MSH6SUPT16HBioGRID22939629 details
MSH6ATP6V1B2BioGRID22863883 details
MSH6GANABBioGRID22863883 details
MSH6HYOU1BioGRID22863883 details
MSH6SAMHD1BioGRID22863883 details
MSH6SUPT5HBioGRID22863883 details
MSH6POLKBioGRID24038355 details
MSH6RPS6KB2BioGRID25324306 details
MSH6ANKRD17BioGRID26344197 details
MSH6FEN1BioGRID26344197 details
MSH6HDGFBioGRID26344197 details
MSH6POLEBioGRID26344197 details
MSH6PRDX1BioGRID26344197 details
MSH6PRDX2BioGRID26344197 details
MSH6SMC3BioGRID26344197 details
MSH6RAD21BioGRID26344197 details
MSH6NTRK1BioGRID25921289 details
MSH6H3-3ABioGRID26496610 details
MSH6PARP2BioGRID26496610 details
MSH6FAF2BioGRID26389662 details
MSH6POU5F1BioGRID26687479 details
MSH6ZNF746BioGRID25315684 details
MSH6CDC14BBioGRID27880917 details
MSH6CYLDBioGRID27591049 details
MSH6G3BP1BioGRID26777405 details
MSH6UHRF1BioGRID28803780 details
MSH6ZUP1BioGRID29576527 details
MSH6EGLN3BioGRID26972000 details
MSH6TRIM14BioGRID29053956 details
MSH6HIF1ABioGRID27320910 details
MSH6EFTUD2BioGRID28515276 details
MSH6CHD3BioGRID28977666 details
MSH6CDC34BioGRID29564676 details
MSH6SPDL1BioGRID30258100 details
MSH6RIOK1BioGRID21081503 details
MSH6RNF123BioGRID29676528 details
MSH6SNAI1BioGRID29331416 details
MSH6AGR2BioGRID30575818 details
MSH6WWOXBioGRID30619736 details
MSH6RECQL4BioGRID29229926 details
MSH6FBXW7BioGRID29346117 details
MSH6ZBTB38BioGRID29490077 details
MSH6VIRMABioGRID29507755 details
MSH6ACTC1BioGRID30890647 details
MSH6MACROH2A1BioGRID28242625 details
MSH6CCND1BioGRID21654808 details
MSH6NR2C2BioGRID30463901 details
MSH6SLC15A3BioGRID30833792 details
MSH6SNRNP70BioGRID29802200 details
MSH6HSPB1BioGRID30669930 details
MSH6CDC14ABioGRID28675297 details
MSH6CDC25BBioGRID28675297 details
MSH6CDKN3BioGRID28675297 details
MSH6PTPMT1BioGRID28675297 details
MSH6PTPRMBioGRID28675297 details
MSH6MATR3BioGRID29884807 details
MSH6MTMR4BioGRID25659891 details
MSH6BIRC3BioGRID30948266 details
MSH6TRIM28BioGRID29955894 details
MSH6CUL7BioGRID31343991 details
MSH6PLEKHA4BioGRID31091453 details
MSH6PINK1BioGRID31300519 details
MSH6LRRC31BioGRID33005030 details
MSH6CITBioGRID31586073 details
MSH6AURKBBioGRID31586073 details
MSH6KIF23BioGRID31586073 details
MSH6BRD9BioGRID31753913 details
MSH6LRRC59BioGRID32788342 details
MSH6ZNF263BioGRID32051553 details
MSH6BRD4BioGRID31239290 32416067 details
MSH6RMC1BioGRID33144569 details
MSH6UBR5BioGRID32867711 details
MSH6WDR76BioGRID31353912 details
MSH6CENPABioGRID34079125 details
MSH6COILBioGRID34079125 details
MSH6H2BC8BioGRID34079125 details
MSH6ZNF330BioGRID34079125 details
MSH6UNKBioGRID25737280 details
MSH6TRIM25BioGRID29117863 details
MSH6DDX58BioGRID32513696 details