Entity Details

Primary name IL12B
Entity type gene
Source Source Link

Details

PrimaryID3593
RefseqGeneNG_009618
SymbolIL12B
Nameinterleukin 12B
Chromosome5
Location5q33.3
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-19
ModificationDate2021-06-13

Ontological Relatives

UniProt IDsIL12B_HUMAN

GO terms

Show/Hide Table
GOName
GO:0001817 regulation of cytokine production
GO:0001916 positive regulation of T cell mediated cytotoxicity
GO:0002230 positive regulation of defense response to virus by host
GO:0002323 natural killer cell activation involved in immune response
GO:0002827 positive regulation of T-helper 1 type immune response
GO:0002860 positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0004896 cytokine receptor activity
GO:0005125 cytokine activity
GO:0005143 interleukin-12 receptor binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005788 endoplasmic reticulum lumen
GO:0005829 cytosol
GO:0008283 cell population proliferation
GO:0009897 external side of plasma membrane
GO:0010224 response to UV-B
GO:0010536 positive regulation of activation of Janus kinase activity
GO:0016477 cell migration
GO:0019221 cytokine-mediated signaling pathway
GO:0019233 sensory perception of pain
GO:0019953 sexual reproduction
GO:0019955 cytokine binding
GO:0030101 natural killer cell activation
GO:0031906 late endosome lumen
GO:0032693 negative regulation of interleukin-10 production
GO:0032700 negative regulation of interleukin-17 production
GO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production
GO:0032729 positive regulation of interferon-gamma production
GO:0032733 positive regulation of interleukin-10 production
GO:0032735 positive regulation of interleukin-12 production
GO:0032740 positive regulation of interleukin-17 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032816 positive regulation of natural killer cell activation
GO:0032819 positive regulation of natural killer cell proliferation
GO:0032946 positive regulation of mononuclear cell proliferation
GO:0034105 positive regulation of tissue remodeling
GO:0034393 positive regulation of smooth muscle cell apoptotic process
GO:0035722 interleukin-12-mediated signaling pathway
GO:0038155 interleukin-23-mediated signaling pathway
GO:0042088 T-helper 1 type immune response
GO:0042093 T-helper cell differentiation
GO:0042102 positive regulation of T cell proliferation
GO:0042104 positive regulation of activated T cell proliferation
GO:0042164 interleukin-12 alpha subunit binding
GO:0042509 regulation of tyrosine phosphorylation of STAT protein
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0042802 identical protein binding
GO:0042832 defense response to protozoan
GO:0043235 receptor complex
GO:0043382 positive regulation of memory T cell differentiation
GO:0043514 interleukin-12 complex
GO:0044877 protein-containing complex binding
GO:0045672 positive regulation of osteoclast differentiation
GO:0045785 positive regulation of cell adhesion
GO:0046982 protein heterodimerization activity
GO:0048662 negative regulation of smooth muscle cell proliferation
GO:0050671 positive regulation of lymphocyte proliferation
GO:0050709 negative regulation of protein secretion
GO:0050729 positive regulation of inflammatory response
GO:0050829 defense response to Gram-negative bacterium
GO:0051135 positive regulation of NK T cell activation
GO:0051142 positive regulation of NK T cell proliferation
GO:0051607 defense response to virus
GO:0070743 interleukin-23 complex
GO:0071222 cellular response to lipopolysaccharide
GO:0071346 cellular response to interferon-gamma
GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway
GO:1901224 positive regulation of NIK/NF-kappaB signaling
GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
GO:2000318 positive regulation of T-helper 17 type immune response
GO:2000330 positive regulation of T-helper 17 cell lineage commitment

Diseases

Show/Hide Table

Interactions

44 interactions

InteractorPartnerSourcesPublicationsLink
IL12BIL12ABioGRID, HPRD, IntAct10899108 7527811 details
IL12BIL23ABioGRID, I2D, IntAct11114383 12023369 18680750 29997244 details
IL12BIL12BHPRD, IntAct7527811 details
IL12BIL12RB1HPRD, IntAct11114383 7527811 7843232 details
IL12BERP44BioGRID16467190 details
IL12BIL12RB2HPRD11940489 details
IL12BIL23RIntAct12023369 details
IL12BVDRIntAct21310195 details
IL12BRXRAIntAct21310195 details
IL12BHDAC3IntAct21310195 details
IL12BNCOR2IntAct21310195 details
IL12BH4-16IntAct21310195 details
IL12BH4C15IntAct21310195 details
IL12BH4C9IntAct21310195 details
IL12BH4C1IntAct21310195 details
IL12BH4C4IntAct21310195 details
IL12BH4C6IntAct21310195 details
IL12BH4C12IntAct21310195 details
IL12BH4C11IntAct21310195 details
IL12BH4C3IntAct21310195 details
IL12BH4C8IntAct21310195 details
IL12BH4C2IntAct21310195 details
IL12BH4C5IntAct21310195 details
IL12BH4C13IntAct21310195 details
IL12BH4C14IntAct21310195 details
IL12BNR3C1IntAct25202013 details
IL12BCEBPBIntAct25202013 details
IL12BRELAIntAct25202013 details
IL12BNR5A2IntAct33179750 details
IL12BNR2F6IntAct33179750 details
IL12BNR1I2IntAct33179750 details
IL12BGLIS2IntAct33179750 details
IL12BESRRGIntAct33179750 details
IL12BESRRBIntAct33179750 details
IL12BEBF3IntAct33179750 details
IL12BEBF1IntAct33179750 details
IL12BSIX3IntAct33179750 details
IL12BZNF281IntAct33179750 details
IL12BZBTB10IntAct33179750 details
IL12BTFAP4IntAct33179750 details
IL12BTFAP2EIntAct33179750 details
IL12BTFAP2BIntAct33179750 details
IL12BTFAP2AIntAct33179750 details
IL12BSPI1IntAct33179750 details