Entity Details

Primary name ISL1
Entity type gene
Source Source Link

Details

PrimaryID3670
RefseqGeneNG_023040
SymbolISL1
NameISL LIM homeobox 1
Chromosome5
Location5q11.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-19
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsISL1_HUMAN

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0000987 cis-regulatory region sequence-specific DNA binding
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001755 neural crest cell migration
GO:0003139 secondary heart field specification
GO:0003148 outflow tract septum morphogenesis
GO:0003151 outflow tract morphogenesis
GO:0003203 endocardial cushion morphogenesis
GO:0003215 cardiac right ventricle morphogenesis
GO:0003266 regulation of secondary heart field cardioblast proliferation
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007409 axonogenesis
GO:0007507 heart development
GO:0008284 positive regulation of cell population proliferation
GO:0010575 positive regulation of vascular endothelial growth factor production
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0016922 nuclear receptor binding
GO:0021520 spinal cord motor neuron cell fate specification
GO:0021522 spinal cord motor neuron differentiation
GO:0021524 visceral motor neuron differentiation
GO:0021559 trigeminal nerve development
GO:0021983 pituitary gland development
GO:0030331 estrogen receptor binding
GO:0031016 pancreas development
GO:0031103 axon regeneration
GO:0031290 retinal ganglion cell axon guidance
GO:0031333 negative regulation of protein-containing complex assembly
GO:0032024 positive regulation of insulin secretion
GO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production
GO:0032729 positive regulation of interferon-gamma production
GO:0032730 positive regulation of interleukin-1 alpha production
GO:0032731 positive regulation of interleukin-1 beta production
GO:0032735 positive regulation of interleukin-12 production
GO:0032755 positive regulation of interleukin-6 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway
GO:0035066 positive regulation of histone acetylation
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0043388 positive regulation of DNA binding
GO:0043425 bHLH transcription factor binding
GO:0043524 negative regulation of neuron apoptotic process
GO:0045597 positive regulation of cell differentiation
GO:0045665 negative regulation of neuron differentiation
GO:0045766 positive regulation of angiogenesis
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046872 metal ion binding
GO:0048665 neuron fate specification
GO:0048762 mesenchymal cell differentiation
GO:0048880 sensory system development
GO:0048936 peripheral nervous system neuron axonogenesis
GO:0050680 negative regulation of epithelial cell proliferation
GO:0050728 negative regulation of inflammatory response
GO:0055010 ventricular cardiac muscle tissue morphogenesis
GO:0060037 pharyngeal system development
GO:0060379 cardiac muscle cell myoblast differentiation
GO:0060384 innervation
GO:0060413 atrial septum morphogenesis
GO:0060913 cardiac cell fate determination
GO:0060931 sinoatrial node cell development
GO:0071385 cellular response to glucocorticoid stimulus
GO:0071657 positive regulation of granulocyte colony-stimulating factor production
GO:0086091 regulation of heart rate by cardiac conduction
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:1901258 positive regulation of macrophage colony-stimulating factor production
GO:1990837 sequence-specific double-stranded DNA binding
GO:1990841 promoter-specific chromatin binding

Diseases

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Interactions

40 interactions

InteractorPartnerSourcesPublicationsLink
ISL1CDKN2BBioGRID, IntAct21988832 details
ISL1SMAD3BioGRID, IntAct21988832 details
ISL1RELABioGRID, IntAct21988832 details
ISL1CDK6BioGRID, IntAct22094256 details
ISL1KDM1ABioGRID, MINT23455924 details
ISL1PLCG2BioGRID, IntAct25814554 details
ISL1CRKBioGRID, IntAct25814554 details
ISL1ZNF511BioGRID, IntAct25416956 31515488 32296183 details
ISL1LDB1BioGRID, HPRD, IntAct20211142 24981860 32296183 9452425 details
ISL1LHX4BioGRID, IntAct20211142 26186194 28514442 31515488 details
ISL1SSBP4BioGRID, IntAct20211142 24981860 26186194 28514442 details
ISL1GMNNIntAct22615398 details
ISL1LDB2BioGRID, IntAct20211142 details
ISL1ISL1BioGRID9452425 details
ISL1LMX1ABioGRID, HPRD9452425 details
ISL1LHX3BioGRID, HPRD9452425 details
ISL1ISL2BioGRID, HPRD9452425 details
ISL1LMO2BioGRID, HPRD9452425 details
ISL1ESR1BioGRID, HPRD11043578 details
ISL1PECRBioGRID, HPRD11043578 details
ISL1NR2F1BioGRID, HPRD11043578 details
ISL1APPBioGRID21832049 details
ISL1HNF4ABioGRID17022998 details
ISL1MAFABioGRID26180087 details
ISL1MAFBBioGRID26180087 details
ISL1RNF20BioGRID31186351 details
ISL1RNF40BioGRID31186351 details
ISL1RLIMHPRD10431247 11882901 details
ISL1LHX1HPRD9452425 details
ISL1COPS5BioGRID, IntAct21145461 details
ISL1NFATC1BioGRID, MINT25609649 details
ISL1SSBP2BioGRID, IntAct24981860 26186194 28514442 details
ISL1ARIH1BioGRID, IntAct28514442 details
ISL1SSBP3BioGRID, IntAct24981860 26186194 28514442 details
ISL1PYGO1BioGRID, MINT24981860 details
ISL1BCL9LBioGRID24981860 details
ISL1BCL9BioGRID24981860 details
ISL1IFNA10IntAct33179750 details
ISL1IFNA4IntAct33179750 details
ISL1IFNA7IntAct33179750 details