Entity Details

Primary name ITGB2
Entity type gene
Source Source Link

Details

PrimaryID3689
RefseqGeneNG_007270
SymbolITGB2
Nameintegrin subunit beta 2
Chromosome21
Location21q22.3
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-19
ModificationDate2021-06-21

Ontological Relatives

UniProt IDsITB2_HUMAN

GO terms

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GOName
GO:0001540 amyloid-beta binding
GO:0001774 microglial cell activation
GO:0001851 complement component C3b binding
GO:0002523 leukocyte migration involved in inflammatory response
GO:0005178 integrin binding
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0006898 receptor-mediated endocytosis
GO:0006911 phagocytosis, engulfment
GO:0006915 apoptotic process
GO:0006954 inflammatory response
GO:0007155 cell adhesion
GO:0007159 leukocyte cell-cell adhesion
GO:0007160 cell-matrix adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0007267 cell-cell signaling
GO:0007568 aging
GO:0008305 integrin complex
GO:0008360 regulation of cell shape
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016477 cell migration
GO:0019221 cytokine-mediated signaling pathway
GO:0019901 protein kinase binding
GO:0030101 natural killer cell activation
GO:0030198 extracellular matrix organization
GO:0030369 ICAM-3 receptor activity
GO:0030593 neutrophil chemotaxis
GO:0031072 heat shock protein binding
GO:0031623 receptor internalization
GO:0032930 positive regulation of superoxide anion generation
GO:0033627 cell adhesion mediated by integrin
GO:0034113 heterotypic cell-cell adhesion
GO:0034142 toll-like receptor 4 signaling pathway
GO:0034687 integrin alphaL-beta2 complex
GO:0034688 integrin alphaM-beta2 complex
GO:0034689 integrin alphaX-beta2 complex
GO:0035579 specific granule membrane
GO:0035987 endodermal cell differentiation
GO:0043113 receptor clustering
GO:0043235 receptor complex
GO:0043312 neutrophil degranulation
GO:0043315 positive regulation of neutrophil degranulation
GO:0043542 endothelial cell migration
GO:0044853 plasma membrane raft
GO:0045123 cellular extravasation
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045766 positive regulation of angiogenesis
GO:0045963 negative regulation of dopamine metabolic process
GO:0046872 metal ion binding
GO:0050730 regulation of peptidyl-tyrosine phosphorylation
GO:0050776 regulation of immune response
GO:0050839 cell adhesion molecule binding
GO:0050900 leukocyte migration
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0070062 extracellular exosome
GO:0070821 tertiary granule membrane
GO:0071404 cellular response to low-density lipoprotein particle stimulus
GO:0090314 positive regulation of protein targeting to membrane
GO:0097242 amyloid-beta clearance
GO:0098609 cell-cell adhesion
GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules
GO:0101003 ficolin-1-rich granule membrane
GO:1901216 positive regulation of neuron death
GO:1903561 extracellular vesicle
GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell
GO:1990266 neutrophil migration
GO:2000363 positive regulation of prostaglandin-E synthase activity

Diseases

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Interactions

72 interactions

InteractorPartnerSourcesPublicationsLink
ITGB2COPS3HPRD, MINT10766246 details
ITGB2RANBP9BioGRID, HPRD, MINT14722085 details
ITGB2RDXHPRD, MINT17321526 details
ITGB2CYTH1BioGRID, HPRD, MINT10835351 17321526 9765275 details
ITGB2TLN2MINT19234221 details
ITGB2LYNmbinfo14593208 details
ITGB2ITGAXDIP, HPRD, I2D11937543 20033057 20679211 7621072 details
ITGB2EGFRBioGRID, IntAct24658140 25402006 31980649 details
ITGB2NOTCH2NLABioGRID, IntAct25416956 25910212 31515488 32296183 details
ITGB2CYSRT1BioGRID, IntAct32296183 details
ITGB2SCML1BioGRID, IntAct32296183 details
ITGB2TM4SF18BioGRID, IntAct32296183 details
ITGB2MTIF3BioGRID, IntAct32296183 details
ITGB2MS4A7BioGRID, IntAct32296183 details
ITGB2LHFPL5BioGRID, IntAct32296183 details
ITGB2APOL2BioGRID, IntAct32296183 details
ITGB2ADAMTSL4BioGRID, IntAct32296183 details
ITGB2KRTAP10-8BioGRID, IntAct32296183 details
ITGB2KRT31BioGRID, IntAct32296183 details
ITGB2UPK1BBioGRID, IntAct32296183 details
ITGB2CX3CL1IntAct24789099 details
ITGB2FOXD4L6IntAct32814053 details
ITGB2KEAP1IntAct32814053 details
ITGB2RACK1BioGRID, HPRD9442085 details
ITGB2ICAM1BioGRID, HPRD10352278 11279101 20187292 7642561 details
ITGB2FHL2BioGRID, HPRD10906324 details
ITGB2KNG1BioGRID, HPRD10845911 details
ITGB2COPS5BioGRID10766246 details
ITGB2PRKCBBioGRID, HPRD11700305 details
ITGB2PRKCDBioGRID, HPRD11700305 details
ITGB2PRKCABioGRID, HPRD11700305 details
ITGB2PRKCEBioGRID11700305 details
ITGB2PRKCGBioGRID11700305 details
ITGB2C3BioGRID4062888 details
ITGB2SHARPINBioGRID26600301 details
ITGB2CYTH2HPRD8706128 details
ITGB2SYKBioGRID, HPRD, IntAct10961871 12885943 details
ITGB2ABL1MINT19234221 details
ITGB2VAV1MINT19234221 details
ITGB2CD177UniProt21193407 details
ITGB2TGFBIIntAct18083624 details
ITGB2ITGAMHPRD, IntAct18083624 2454931 details
ITGB2PLAURBioGRID10388537 details
ITGB2ITGALBioGRID9442085 details
ITGB2ITGADBioGRID, HPRD8777714 details
ITGB2PTK2BBioGRID, HPRD10961871 details
ITGB2VNN2BioGRID, HPRD12056825 details
ITGB2CD226BioGRID, HPRD10591186 details
ITGB2PSMD4BioGRID16762342 details
ITGB2YWHABBioGRID11700305 18239087 details
ITGB2YWHAZBioGRID11700305 details
ITGB2LCP1BioGRID30333137 details
ITGB2PRTN3HPRD12960243 details
ITGB2TLN1HPRD12606711 2150484 details
ITGB2ITGB2HPRD9419363 details
ITGB2ESM1HPRD11544294 details
ITGB2ICAM5HPRD8995416 details
ITGB2ILKHPRD9736715 details
ITGB2DOK1HPRD12606711 details
ITGB2DAB1HPRD12606711 details
ITGB2NUMBHPRD12606711 details
ITGB2PRKCHHPRD11700305 details
ITGB2CD82HPRD10602019 details
ITGB2ICAM4HPRD10846180 details
ITGB2HPHPRD11967116 details
ITGB2ICAM2HPRD9786897 details
ITGB2ICAM3HPRD11353828 7822326 details
ITGB2FUT4HPRD3305706 details
ITGB2FCER2HPRD7621072 details
ITGB2CD14HPRD11745332 details
ITGB2TEX101BioGRID, UniProt30097533 details
ITGB2DDX58BioGRID32513696 details