Entity Details

Primary name RHEB_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ15382
EntryNameRHEB_HUMAN
FullNameGTP-binding protein Rheb
TaxID9606
Evidenceevidence at protein level
Length184
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesRHEB

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0000287 magnesium ion binding
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0005681 spliceosomal complex
GO:0005765 lysosomal membrane
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0016241 regulation of macroautophagy
GO:0019003 GDP binding
GO:0019901 protein kinase binding
GO:0032008 positive regulation of TOR signaling
GO:0034198 cellular response to amino acid starvation
GO:0048714 positive regulation of oligodendrocyte differentiation
GO:0070062 extracellular exosome
GO:0120163 negative regulation of cold-induced thermogenesis
GO:2000074 regulation of type B pancreatic cell development

Subcellular Location

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Subcellular Location
Cytoplasm
Endomembrane system
Endoplasmic reticulum membrane
Golgi apparatus membrane

Domains

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DomainNameCategoryType
IPR001806 Small GTPaseFamilyFamily
IPR005225 Small GTP-binding protein domainDomainDomain
IPR020849 Small GTPase, Ras-typeFamilyFamily
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR037586 GTP-binding protein RhebFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB04137 Guanosine-5'-TriphosphateDrugbanksmall molecule
DB04315 Guanosine-5'-DiphosphateDrugbanksmall molecule

Interactions

45 interactions

InteractorPartnerSourcesPublicationsLink
RHEB_HUMANMTOR_HUMANBioGRID, DIP, HPRD, MINT15772076 15854902 15878852 16098514 16631613 16915281 18550814 25351248 details
RHEB_HUMANRAF1_HUMANBioGRID, HPRD, MINT15150271 15854902 16803888 19222999 9001246 details
RHEB_HUMANA2MG_HUMANBioGRID, IntAct21163940 details
RHEB_HUMANECSIT_HUMANBioGRID, IntAct21163940 details
RHEB_HUMANPSN2_HUMANBioGRID, IntAct21163940 details
RHEB_HUMANCREB3_HUMANBioGRID, IntAct, MINT21516116 31515488 details
RHEB_HUMANNCAM1_HUMANBioGRID, IntAct21988832 details
RHEB_HUMANARI2_HUMANBioGRID, IntAct21988832 details
RHEB_HUMANRPTOR_HUMANBioGRID, HPRD, IntAct15854902 16631613 24337580 25446900 details
RHEB_HUMANAPBP2_HUMANBioGRID, IntAct32296183 details
RHEB_HUMANLAMP2_HUMANBioGRID, IntAct28514442 32814053 details
RHEB_HUMANTCTP_HUMANDIP17301792 details
RHEB_HUMANPLD1_HUMANBioGRID, DIP18550814 details
RHEB_HUMANPDE6D_HUMANBioGRID, DIP, HPRD11980706 23698361 details
RHEB_HUMANPCNA_HUMANUniProt26030842 details
RHEB_HUMANTRI63_HUMANBioGRID, IntAct31391242 details
RHEB_HUMANTRI55_HUMANBioGRID, IntAct31391242 details
RHEB_HUMANCASP6_HUMANIntAct32814053 details
RHEB_HUMANCCKN_HUMANIntAct32814053 details
RHEB_HUMANFGFR3_HUMANIntAct32814053 details
RHEB_HUMANNMDE3_HUMANIntAct32814053 details
RHEB_HUMANHIP1_HUMANIntAct32814053 details
RHEB_HUMANRAN_HUMANIntAct32814053 details
RHEB_HUMANUBQL1_HUMANIntAct32814053 details
RHEB_HUMANPR40A_HUMANIntAct32814053 details
RHEB_HUMANTSC2_HUMANBioGRID, HPRD12771962 12820960 12842888 12869586 15854902 17077083 30514904 details
RHEB_HUMANATM_HUMANBioGRID, HPRD15854902 details
RHEB_HUMANATR_HUMANBioGRID, HPRD15854902 details
RHEB_HUMANTSC1_HUMANBioGRID12820960 30514904 details
RHEB_HUMANAPOE_HUMANBioGRID21163940 details
RHEB_HUMANPSN1_HUMANBioGRID21163940 details
RHEB_HUMANBNIP3_HUMANBioGRID17928295 details
RHEB_HUMANBNI3L_HUMANBioGRID17928295 details
RHEB_HUMANPRAF1_HUMANBioGRID17928295 details
RHEB_HUMANFKBP8_HUMANBioGRID17991864 details
RHEB_HUMANKS6B1_HUMANBioGRID18550814 details
RHEB_HUMANHD_HUMANBioGRID25351248 details
RHEB_HUMANRN152_HUMANBioGRID30514904 details
RHEB_HUMANUBP4_HUMANBioGRID30514904 details
RHEB_HUMANEIF1B_HUMANIntAct17353931 details
RHEB_HUMANRASH_HUMANBioGRID15854902 details
RHEB_HUMANRAP1A_HUMANBioGRID15854902 details
RHEB_HUMANRAB7A_HUMANBioGRID15809346 26344197 details
RHEB_HUMANRAB9A_HUMANBioGRID15809346 details
RHEB_HUMANBRAF_HUMANHPRD16803888 details