Entity Details

Primary name NCOA1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ15788
EntryNameNCOA1_HUMAN
FullNameNuclear receptor coactivator 1
TaxID9606
Evidenceevidence at protein level
Length1441
SequenceStatuscomplete
DateCreated2004-10-11
DateModified2021-06-02

Ontological Relatives

GenesNCOA1

GO terms

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GOName
GO:0000435 positive regulation of transcription from RNA polymerase II promoter by galactose
GO:0000785 chromatin
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0002155 regulation of thyroid hormone mediated signaling pathway
GO:0003682 chromatin binding
GO:0003713 transcription coactivator activity
GO:0004402 histone acetyltransferase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0007595 lactation
GO:0008584 male gonad development
GO:0015721 bile acid and bile salt transport
GO:0016922 nuclear receptor binding
GO:0017162 aryl hydrocarbon receptor binding
GO:0019216 regulation of lipid metabolic process
GO:0019899 enzyme binding
GO:0021549 cerebellum development
GO:0021766 hippocampus development
GO:0021854 hypothalamus development
GO:0021987 cerebral cortex development
GO:0030331 estrogen receptor binding
GO:0030374 nuclear receptor coactivator activity
GO:0030522 intracellular receptor signaling pathway
GO:0032355 response to estradiol
GO:0032526 response to retinoic acid
GO:0032570 response to progesterone
GO:0032870 cellular response to hormone stimulus
GO:0032991 protein-containing complex
GO:0033142 progesterone receptor binding
GO:0043005 neuron projection
GO:0043065 positive regulation of apoptotic process
GO:0043967 histone H4 acetylation
GO:0044849 estrous cycle
GO:0044877 protein-containing complex binding
GO:0045666 positive regulation of neuron differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045925 positive regulation of female receptivity
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046965 retinoid X receptor binding
GO:0046983 protein dimerization activity
GO:0047485 protein N-terminus binding
GO:0060179 male mating behavior
GO:0060713 labyrinthine layer morphogenesis
GO:1904017 cellular response to Thyroglobulin triiodothyronine
GO:2001038 regulation of cellular response to drug

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000014 PAS domainDomainDomain
IPR009110 Nuclear receptor coactivator, interlockingFamilyHomologous superfamily
IPR010011 Nuclear receptor coactivator, DUF1518DomainDomain
IPR011598 Myc-type, basic helix-loop-helix (bHLH) domainDomainDomain
IPR013767 PAS foldDomainDomain
IPR014920 Nuclear receptor coactivator, Ncoa-type, interlockingDomainDomain
IPR014935 Nuclear receptor coactivator, receptor-binding domainDomainDomain
IPR017426 Nuclear receptor coactivatorFamilyFamily
IPR028819 Nuclear receptor coactivator 1FamilyFamily
IPR035965 PAS domain superfamilyFamilyHomologous superfamily
IPR036638 Helix-loop-helix DNA-binding domain superfamilyFamilyHomologous superfamily
IPR037077 Nuclear receptor coactivator, Ncoa-type, interlocking domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB01645 GenisteinDrugbanksmall molecule
DB04652 CorticosteroneDrugbanksmall molecule
DB06832 PrinaberelDrugbanksmall molecule
DB06875 ERB-196Drugbanksmall molecule
DB06908 (2S)-3-(1-{[2-(2-CHLOROPHENYL)-5-METHYL-1,3-OXAZOL-4-YL]METHYL}-1H-INDOL-5-YL)-2-ETHOXYPROPANOIC ACIDDrugbanksmall molecule
DB06927 [5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-YL]ACETONITRILEDrugbanksmall molecule
DB07009 2-(5-HYDROXY-NAPHTHALEN-1-YL)-1,3-BENZOOXAZOL-6-OLDrugbanksmall molecule
DB07080 TO-901317Drugbanksmall molecule
DB07119 1-CHLORO-6-(4-HYDROXYPHENYL)-2-NAPHTHOLDrugbanksmall molecule
DB07150 4-(4-HYDROXYPHENYL)-1-NAPHTHALDEHYDE OXIMEDrugbanksmall molecule
DB07198 5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-CARBONITRILEDrugbanksmall molecule
DB07215 GW-590735Drugbanksmall molecule
DB07230 3-BROMO-6-HYDROXY-2-(4-HYDROXYPHENYL)-1H-INDEN-1-ONEDrugbanksmall molecule
DB07236 3-(6-HYDROXY-NAPHTHALEN-2-YL)-BENZO[D]ISOOXAZOL-6-OLDrugbanksmall molecule
DB07530 (1R,3R)-5-[(2E)-3-{(1S,3R)-2,2,3-trimethyl-3-[6,6,6-trifluoro-5-hydroxy-5-(trifluoromethyl)hex-3-yn-1-yl]cyclopentyl}prop-2-en-1-ylidene]cyclohexane-1,3-diolDrugbanksmall molecule
DB07557 3,20-PregnanedioneDrugbanksmall molecule
DB07724 IndeglitazarDrugbanksmall molecule
DB08220 (8alpha,10alpha,13alpha,17beta)-17-[(4-hydroxyphenyl)carbonyl]androsta-3,5-diene-3-carboxylic acidDrugbanksmall molecule
DB08231 Myristic acidDrugbanksmall molecule
DB08742 1,3-CYCLOHEXANEDIOL, 4-METHYLENE-5-[(2E)-[(1S,3AS,7AS)-OCTAHYDRO-1-(5-HYDROXY-5-METHYL-1,3-HEXADIYNYL)-7A-METHYL-4H-INDEN-4-YLIDENE]ETHYLIDENE]-, (1R,3S,5Z)Drugbanksmall molecule
DB08915 AleglitazarDrugbanksmall molecule

Interactions

109 interactions

InteractorPartnerSourcesPublicationsLink
NCOA1_HUMANCBP_HUMANBioGRID, HPRD, MINT, UniProt11003650 11113179 11971985 12163591 12482968 14722092 15615775 16860316 8616895 9192892 9445475 details
NCOA1_HUMANRARA_HUMANBioGRID, DIP, HPRD, MINT, UniProt10082574 10454579 10760302 12138096 12665583 16456540 16606617 17363140 17475621 17641689 20338915 20543827 21478865 23975195 9121466 9192892 details
NCOA1_HUMANPSB9_HUMANHPRD, MINT16957778 details
NCOA1_HUMANESR1_HUMANBioGRID, HPRD, IntAct, MINT, UniProt10454579 10598586 10731636 10760302 11003650 11014206 11113179 11165056 11358671 11376110 11682626 11867769 12554772 12574227 12630920 12714702 12738788 14715875 15140878 15604093 16282588 16606617 16957778 17363140 17627277 20608937 23874500 23975195 26487511 9121466 9192892 9192902 9259327 9427757 9773983 9774463 details
NCOA1_HUMANANDR_HUMANBioGRID, HPRD, IntAct10567563 10731636 12163482 12612084 15256534 17353003 23975195 details
NCOA1_HUMANNCOA3_HUMANBioGRID, MINT17476305 18267973 details
NCOA1_HUMANGRIP1_HUMANMINT17476305 details
NCOA1_HUMANKANK2_HUMANBioGRID, MINT17476305 details
NCOA1_HUMANRXRA_HUMANBioGRID, DIP, HPRD, IntAct, MINT10082574 10454579 10517671 10935544 11027271 11124027 11438648 12612084 15140878 17363140 17673910 20682316 21478865 23602807 23975195 7481822 9121466 9171239 details
NCOA1_HUMANPAGR1_HUMANBioGRID, MINT19039327 details
NCOA1_HUMANNR1H3_HUMANBioGRID, MINT15604093 20682316 25962847 details
NCOA1_HUMANGCR_HUMANBioGRID, HPRD, UniProt10659697 10731636 11266503 12118039 12569182 12917342 16423881 16606617 28611094 31182584 9590696 details
NCOA1_HUMANSNW1_HUMANBioGRID, UniProt14985122 details
NCOA1_HUMANRORG_HUMANIntAct20203100 details
NCOA1_HUMANRORA_HUMANBioGRID, IntAct15604093 20203100 23975195 details
NCOA1_HUMANESR2_HUMANBioGRID, HPRD, IntAct10731636 10809226 11014206 11376110 11500849 12554772 14715875 15604093 19126643 details
NCOA1_HUMANNR1H4_HUMANBioGRID, DIP, HPRD, UniProt11136553 14684751 14698205 18391212 20338915 details
NCOA1_HUMANTRI27_HUMANBioGRID, IntAct32296183 details
NCOA1_HUMANNR1I2_HUMANBioGRID, HPRD, IntAct12072427 12909012 15331348 15604093 16455805 17429319 18096694 19171678 23160820 23602807 details
NCOA1_HUMANPPARA_HUMANBioGRID, IntAct10731636 12163133 15888456 21775429 9407140 9626662 details
NCOA1_HUMANPPARD_HUMANBioGRID, IntAct15001550 15604093 15888456 16930961 21775429 details
NCOA1_HUMANNR1I3_HUMANBioGRID, HPRD, IntAct15572376 15604093 26186194 28514442 details
NCOA1_HUMANVDR_HUMANBioGRID, DIP, HPRD, IntAct10224118 11075811 11124027 11149488 12403843 12612084 12796488 15604093 17786964 21478865 23975195 9121466 9878542 details
NCOA1_HUMANNR5A2_HUMANBioGRID, DIP15604093 22504882 23975195 details
NCOA1_HUMANERR1_HUMANBioGRID, HPRD, IntAct11165056 15337744 15604093 23975195 details
NCOA1_HUMANPRGR_HUMANBioGRID, HPRD, IntAct10722692 10757795 12529333 16282588 16352595 16728408 21273440 29202468 7481822 details
NCOA1_HUMANFOS_HUMANBioGRID, HPRD10847592 18511550 9642216 details
NCOA1_HUMANJUN_HUMANBioGRID, HPRD10567404 10847592 9642216 details
NCOA1_HUMANNFKB1_HUMANBioGRID, HPRD10847592 9556555 details
NCOA1_HUMANC2TA_HUMANBioGRID, HPRD12933903 details
NCOA1_HUMANSMCE1_HUMANBioGRID, HPRD12145209 16538531 17363140 details
NCOA1_HUMANBCL3_HUMANBioGRID, HPRD10497212 details
NCOA1_HUMAN1433T_HUMANBioGRID11266503 details
NCOA1_HUMANSTAT6_HUMANBioGRID, HPRD11574547 12138096 14757047 14993689 15695802 18267973 details
NCOA1_HUMANTRIP4_HUMANBioGRID, HPRD10454579 details
NCOA1_HUMANKAT2B_HUMANBioGRID, HPRD9223281 9296499 9445475 details
NCOA1_HUMANANM1_HUMANBioGRID, HPRD11050077 details
NCOA1_HUMANNR4A1_HUMANBioGRID, HPRD12082103 16002533 details
NCOA1_HUMANNCOR1_HUMANBioGRID12569182 details
NCOA1_HUMANFOXA2_HUMANBioGRID, HPRD11069927 details
NCOA1_HUMANRARB_HUMANBioGRID, HPRD12665583 15604093 17363140 8754792 details
NCOA1_HUMANTF2B_HUMANBioGRID, HPRD8754792 details
NCOA1_HUMANTBP_HUMANBioGRID, HPRD8754792 details
NCOA1_HUMANTEAD2_HUMANBioGRID, HPRD10934189 details
NCOA1_HUMANTEAD1_HUMANBioGRID10934189 details
NCOA1_HUMANSTAT3_HUMANBioGRID, HPRD11773079 17471507 details
NCOA1_HUMANHNF4A_HUMANBioGRID, HPRD9812974 details
NCOA1_HUMANHIF1A_HUMANBioGRID, HPRD10594042 details
NCOA1_HUMANSTF1_HUMANBioGRID, HPRD9328345 details
NCOA1_HUMANCCND1_HUMANBioGRID, HPRD9832502 details
NCOA1_HUMANERR3_HUMANBioGRID, HPRD11864604 15604093 details
NCOA1_HUMANTHB_HUMANBioGRID, HPRD10454579 11435616 12612084 15249124 15604093 23975195 9121466 9171239 9751500 details
NCOA1_HUMANNR2F6_HUMANBioGRID, HPRD10713182 details
NCOA1_HUMANPRGC1_HUMANBioGRID, HPRD10558993 details
NCOA1_HUMANCARM1_HUMANBioGRID, HPRD10381882 16923966 18511550 details
NCOA1_HUMANNKX21_HUMANBioGRID, HPRD11076796 11713256 15449938 details
NCOA1_HUMANPPARG_HUMANBioGRID, HPRD10339548 10347167 10731636 10848596 11027271 11500849 11877444 15026545 15888456 17011503 17312272 17449869 17468099 17513608 17704298 19596656 20717101 22070604 23178929 23975195 30595551 30813326 9041124 9121466 9744270 details
NCOA1_HUMANTHA_HUMANBioGRID, HPRD10379889 11117530 11435616 15140878 15249124 9804773 9849963 details
NCOA1_HUMANEP300_HUMANBioGRID, HPRD10973497 11113179 12208951 14722092 20368990 details
NCOA1_HUMANRARG_HUMANBioGRID, HPRD12665583 15604093 17363140 details
NCOA1_HUMANNCOA6_HUMANBioGRID10567404 12482968 21292004 details
NCOA1_HUMANP53_HUMANBioGRID10551785 details
NCOA1_HUMANCSN5_HUMANBioGRID, HPRD10722692 details
NCOA1_HUMANAHR_HUMANBioGRID, HPRD12024042 15641800 details
NCOA1_HUMANCXAR_HUMANBioGRID15572376 details
NCOA1_HUMANHNF4G_HUMANBioGRID15604093 23975195 details
NCOA1_HUMANNR6A1_HUMANBioGRID23975195 details
NCOA1_HUMANARI1A_HUMANBioGRID17363140 details
NCOA1_HUMANBRCA1_HUMANBioGRID16860316 details
NCOA1_HUMANNR1H2_HUMANBioGRID15604093 details
NCOA1_HUMANRXRB_HUMANBioGRID, HPRD15604093 7481822 details
NCOA1_HUMANSRF_HUMANBioGRID, HPRD9786846 details
NCOA1_HUMANHNF1A_HUMANBioGRID10777539 details
NCOA1_HUMANMCR_HUMANBioGRID10935545 15604093 details
NCOA1_HUMANFOXO1_HUMANBioGRID10973497 details
NCOA1_HUMANARNT_HUMANBioGRID, HPRD10594042 12024042 details
NCOA1_HUMANSMRC1_HUMANBioGRID15923603 details
NCOA1_HUMANANR11_HUMANBioGRID15184363 details
NCOA1_HUMANDDX5_HUMANHPRD11250900 details
NCOA1_HUMANCOT1_HUMANHPRD10652338 details
NCOA1_HUMANNCOA1_HUMANBioGRID, HPRD, IntAct10334992 10334993 23602807 9774463 details
NCOA1_HUMANTDG_HUMANIntAct16282588 details
NCOA1_HUMANTNIK_HUMANIntAct31413325 details
NCOA1_HUMANNCOA2_HUMANBioGRID11971985 18267973 9751728 9774463 details
NCOA1_HUMANRO52_HUMANBioGRID11971985 details
NCOA1_HUMANSTA5A_HUMANBioGRID12954634 details
NCOA1_HUMANRBBP6_HUMANBioGRID16051665 20184719 details
NCOA1_HUMANUB2L3_HUMANBioGRID15367689 details
NCOA1_HUMANTIF1A_HUMANBioGRID9774463 details
NCOA1_HUMANEZH2_HUMANBioGRID17502350 details
NCOA1_HUMANETS2_HUMANBioGRID15788656 details
NCOA1_HUMANETS1_HUMANBioGRID15788656 details
NCOA1_HUMANSF01_HUMANBioGRID16002533 details
NCOA1_HUMANWDHD1_HUMANBioGRID16051665 details
NCOA1_HUMANSYTL2_HUMANBioGRID16051665 details
NCOA1_HUMANHSP72_HUMANBioGRID16051665 details
NCOA1_HUMANBIP_HUMANBioGRID16051665 details
NCOA1_HUMANKCTD3_HUMANBioGRID16051665 details
NCOA1_HUMANTERA_HUMANBioGRID16051665 details
NCOA1_HUMANITCH_HUMANBioGRID16051665 details
NCOA1_HUMANTRIPB_HUMANBioGRID16051665 details
NCOA1_HUMANUBR5_HUMANBioGRID16051665 details
NCOA1_HUMANSMAD3_HUMANBioGRID16423881 details
NCOA1_HUMANNR4A2_HUMANBioGRID21757690 details
NCOA1_HUMANSMG7_HUMANBioGRID29395067 details
NCOA1_HUMANMK01_HUMANHPRD10660621 details
NCOA1_HUMAN1433F_HUMANHPRD11266503 details
NCOA1_HUMANSUMO1_HUMANHPRD12529333 details
NCOA1_HUMANANM2_HUMANHPRD12039952 details