Entity Details

Primary name NTRK2
Entity type gene
Source Source Link

Details

PrimaryID4915
RefseqGeneNG_012201
SymbolNTRK2
Nameneurotrophic receptor tyrosine kinase 2
Chromosome9
Location9q21.33
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-21
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsNTRK2_HUMAN

GO terms

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GOName
GO:0001570 vasculogenesis
GO:0001764 neuron migration
GO:0001934 positive regulation of protein phosphorylation
GO:0002020 protease binding
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005030 neurotrophin receptor activity
GO:0005524 ATP binding
GO:0005769 early endosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007202 activation of phospholipase C activity
GO:0007275 multicellular organism development
GO:0007612 learning
GO:0007623 circadian rhythm
GO:0007631 feeding behavior
GO:0008284 positive regulation of cell population proliferation
GO:0010628 positive regulation of gene expression
GO:0010976 positive regulation of neuron projection development
GO:0014047 glutamate secretion
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014069 postsynaptic density
GO:0019227 neuronal action potential propagation
GO:0021954 central nervous system neuron development
GO:0021987 cerebral cortex development
GO:0022011 myelination in peripheral nervous system
GO:0030182 neuron differentiation
GO:0030424 axon
GO:0030425 dendrite
GO:0031547 brain-derived neurotrophic factor receptor signaling pathway
GO:0031901 early endosome membrane
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0033674 positive regulation of kinase activity
GO:0042490 mechanoreceptor differentiation
GO:0042803 protein homodimerization activity
GO:0043087 regulation of GTPase activity
GO:0043121 neurotrophin binding
GO:0043195 terminal bouton
GO:0043197 dendritic spine
GO:0043235 receptor complex
GO:0043410 positive regulation of MAPK cascade
GO:0043524 negative regulation of neuron apoptotic process
GO:0043679 axon terminus
GO:0046548 retinal rod cell development
GO:0046777 protein autophosphorylation
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048403 brain-derived neurotrophic factor binding
GO:0048471 perinuclear region of cytoplasm
GO:0048709 oligodendrocyte differentiation
GO:0048935 peripheral nervous system neuron development
GO:0050772 positive regulation of axonogenesis
GO:0051896 regulation of protein kinase B signaling
GO:0051965 positive regulation of synapse assembly
GO:0060175 brain-derived neurotrophic factor-activated receptor activity
GO:0060291 long-term synaptic potentiation
GO:0071230 cellular response to amino acid stimulus
GO:0099183 trans-synaptic signaling by BDNF, modulating synaptic transmission
GO:0099551 trans-synaptic signaling by neuropeptide, modulating synaptic transmission
GO:1902430 negative regulation of amyloid-beta formation
GO:1903997 positive regulation of non-membrane spanning protein tyrosine kinase activity
GO:1990090 cellular response to nerve growth factor stimulus
GO:1990416 cellular response to brain-derived neurotrophic factor stimulus
GO:2000811 negative regulation of anoikis

Diseases

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Interactions

48 interactions

InteractorPartnerSourcesPublicationsLink
NTRK2AP1B1BioGRID, IntAct21988832 details
NTRK2POLR2GBioGRID, IntAct21988832 details
NTRK2NMNAT1BioGRID, IntAct21988832 details
NTRK2NTRK2HPRD, Molecular Connections10533983 22269274 details
NTRK2NTF4BioGRID, HPRD, IntAct11738045 11855816 25241761 29997244 details
NTRK2EGFRBioGRID, IntAct24658140 25402006 31980649 details
NTRK2SORT1bhf-ucl, BioGRID21102451 details
NTRK2NTF3BioGRID, HPRD8621424 details
NTRK2FYNBioGRID, HPRD9648856 details
NTRK2FRS2BioGRID10092678 details
NTRK2SHC1BioGRID, HPRD10092678 12419535 16034442 26253177 28213521 details
NTRK2PLCG1BioGRID, HPRD10092678 12074588 12419535 26253177 details
NTRK2BDNFBioGRID, HPRD11855816 21651720 9312147 details
NTRK2SHC3BioGRID, HPRD12074588 19166614 9507002 details
NTRK2GIPC1BioGRID, HPRD11251075 14617818 15304335 details
NTRK2PIK3R1BioGRID12074588 details
NTRK2SH2B1BioGRID, HPRD12074588 9856458 details
NTRK2NCK2BioGRID, HPRD12074588 details
NTRK2PTPN1BioGRID, HPRD12237455 25288805 details
NTRK2NDFIP1BioGRID29911254 details
NTRK2ERBB4BioGRID25052836 details
NTRK2ERBB2BioGRID30898150 details
NTRK2NCK1HPRD12074588 details
NTRK2DOK5HPRD16647839 details
NTRK2HSP90AB1IntAct22939624 details
NTRK2NR3C1DIP19126684 details
NTRK2DLG4DIP23424281 details
NTRK2SQSTM1BioGRID, HPRD12471037 18457658 details
NTRK2TRAF6BioGRID, HPRD18457658 details
NTRK2HSP90AA1BioGRID22939624 details
NTRK2RANBP9BioGRID20403074 details
NTRK2TNK2BioGRID23598414 details
NTRK2NGFRBioGRID, HPRD28821608 9927421 details
NTRK2SHC4BioGRID28213521 details
NTRK2SOCS2BioGRID29881947 details
NTRK2SNCABioGRID28923922 details
NTRK2KCNA3BioGRID19166614 details
NTRK2GRB10BioGRID19166614 details
NTRK2GRIN1BioGRID26253177 details
NTRK2DYNLL1HPRD11157096 details
NTRK2FRS3HPRD11432792 details
NTRK2KIDINS220HPRD15167895 details
NTRK2PTPN11HPRD10386953 details
NTRK2SH2B2HPRD9856458 details
NTRK2UBBHPRD16701206 details
NTRK2SHC2HPRD12006576 9507002 details
NTRK2RASGRF1HPRD15513915 details
NTRK2PKMIntAct24606918 details