Entity Details

Primary name NTRK2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ16620
EntryNameNTRK2_HUMAN
FullNameBDNF/NT-3 growth factors receptor
TaxID9606
Evidenceevidence at protein level
Length822
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesNTRK2

GO terms

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GOName
GO:0001570 vasculogenesis
GO:0001764 neuron migration
GO:0001934 positive regulation of protein phosphorylation
GO:0002020 protease binding
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005030 neurotrophin receptor activity
GO:0005524 ATP binding
GO:0005769 early endosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007202 activation of phospholipase C activity
GO:0007275 multicellular organism development
GO:0007612 learning
GO:0007623 circadian rhythm
GO:0007631 feeding behavior
GO:0008284 positive regulation of cell population proliferation
GO:0010628 positive regulation of gene expression
GO:0010976 positive regulation of neuron projection development
GO:0014047 glutamate secretion
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014069 postsynaptic density
GO:0019227 neuronal action potential propagation
GO:0021954 central nervous system neuron development
GO:0021987 cerebral cortex development
GO:0022011 myelination in peripheral nervous system
GO:0030182 neuron differentiation
GO:0030424 axon
GO:0030425 dendrite
GO:0031547 brain-derived neurotrophic factor receptor signaling pathway
GO:0031901 early endosome membrane
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0033674 positive regulation of kinase activity
GO:0042490 mechanoreceptor differentiation
GO:0042803 protein homodimerization activity
GO:0043087 regulation of GTPase activity
GO:0043121 neurotrophin binding
GO:0043195 terminal bouton
GO:0043197 dendritic spine
GO:0043235 receptor complex
GO:0043410 positive regulation of MAPK cascade
GO:0043524 negative regulation of neuron apoptotic process
GO:0043679 axon terminus
GO:0046548 retinal rod cell development
GO:0046777 protein autophosphorylation
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048403 brain-derived neurotrophic factor binding
GO:0048471 perinuclear region of cytoplasm
GO:0048709 oligodendrocyte differentiation
GO:0048935 peripheral nervous system neuron development
GO:0050772 positive regulation of axonogenesis
GO:0051896 regulation of protein kinase B signaling
GO:0051965 positive regulation of synapse assembly
GO:0060175 brain-derived neurotrophic factor-activated receptor activity
GO:0060291 long-term synaptic potentiation
GO:0071230 cellular response to amino acid stimulus
GO:0099183 trans-synaptic signaling by BDNF, modulating synaptic transmission
GO:0099551 trans-synaptic signaling by neuropeptide, modulating synaptic transmission
GO:1902430 negative regulation of amyloid-beta formation
GO:1903997 positive regulation of non-membrane spanning protein tyrosine kinase activity
GO:1990090 cellular response to nerve growth factor stimulus
GO:1990416 cellular response to brain-derived neurotrophic factor stimulus
GO:2000811 negative regulation of anoikis

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Cell projection
Cytoplasm
Early endosome membrane
Endosome membrane

Domains

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DomainNameCategoryType
IPR000372 Leucine-rich repeat N-terminal domainDomainDomain
IPR000483 Cysteine-rich flanking region, C-terminalDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR001611 Leucine-rich repeatRepeatRepeat
IPR002011 Tyrosine-protein kinase, receptor class II, conserved siteSiteConserved site
IPR003598 Immunoglobulin subtype 2DomainDomain
IPR003599 Immunoglobulin subtypeDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR013098 Immunoglobulin I-setDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020455 Tyrosine-protein kinase, neurotrophic receptor, type 2FamilyFamily
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR020777 Tyrosine-protein kinase, neurotrophic receptorFamilyFamily
IPR031635 Tyrosine-protein kinase receptor NTRK, C2-Ig-like domainDomainDomain
IPR032675 Leucine-rich repeat domain superfamilyFamilyHomologous superfamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00321 AmitriptylineDrugbanksmall molecule
DB11823 EsketamineDrugbanksmall molecule
DB11986 EntrectinibDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule
DB14723 LarotrectinibDrugbanksmall molecule

Interactions

47 interactions

InteractorPartnerSourcesPublicationsLink
NTRK2_HUMANAP1B1_HUMANBioGRID, IntAct21988832 details
NTRK2_HUMANRPB7_HUMANBioGRID, IntAct21988832 details
NTRK2_HUMANNMNA1_HUMANBioGRID, IntAct21988832 details
NTRK2_HUMANNTRK2_HUMANHPRD, Molecular Connections10533983 22269274 details
NTRK2_HUMANNTF4_HUMANBioGRID, HPRD, IntAct11738045 11855816 25241761 29997244 details
NTRK2_HUMANEGFR_HUMANBioGRID, IntAct24658140 25402006 31980649 details
NTRK2_HUMANSORT_HUMANbhf-ucl, BioGRID21102451 details
NTRK2_HUMANNTF3_HUMANBioGRID, HPRD8621424 details
NTRK2_HUMANFYN_HUMANBioGRID, HPRD9648856 details
NTRK2_HUMANFRS2_HUMANBioGRID10092678 details
NTRK2_HUMANSHC1_HUMANBioGRID, HPRD10092678 12419535 16034442 26253177 28213521 details
NTRK2_HUMANPLCG1_HUMANBioGRID, HPRD10092678 12074588 12419535 26253177 details
NTRK2_HUMANBDNF_HUMANBioGRID, HPRD11855816 21651720 9312147 details
NTRK2_HUMANSHC3_HUMANBioGRID, HPRD12074588 19166614 9507002 details
NTRK2_HUMANGIPC1_HUMANBioGRID, HPRD11251075 14617818 15304335 details
NTRK2_HUMANP85A_HUMANBioGRID12074588 details
NTRK2_HUMANSH2B1_HUMANBioGRID, HPRD12074588 9856458 details
NTRK2_HUMANNCK2_HUMANBioGRID, HPRD12074588 details
NTRK2_HUMANPTN1_HUMANBioGRID, HPRD12237455 25288805 details
NTRK2_HUMANNFIP1_HUMANBioGRID29911254 details
NTRK2_HUMANERBB4_HUMANBioGRID25052836 details
NTRK2_HUMANERBB2_HUMANBioGRID30898150 details
NTRK2_HUMANNCK1_HUMANHPRD12074588 details
NTRK2_HUMANDOK5_HUMANHPRD16647839 details
NTRK2_HUMANHS90B_HUMANIntAct22939624 details
NTRK2_HUMANGCR_HUMANDIP19126684 details
NTRK2_HUMANDLG4_HUMANDIP23424281 details
NTRK2_HUMANSQSTM_HUMANBioGRID, HPRD12471037 18457658 details
NTRK2_HUMANTRAF6_HUMANBioGRID, HPRD18457658 details
NTRK2_HUMANHS90A_HUMANBioGRID22939624 details
NTRK2_HUMANRANB9_HUMANBioGRID20403074 details
NTRK2_HUMANACK1_HUMANBioGRID23598414 details
NTRK2_HUMANTNR16_HUMANBioGRID, HPRD28821608 9927421 details
NTRK2_HUMANSHC4_HUMANBioGRID28213521 details
NTRK2_HUMANSOCS2_HUMANBioGRID29881947 details
NTRK2_HUMANSYUA_HUMANBioGRID28923922 details
NTRK2_HUMANKCNA3_HUMANBioGRID19166614 details
NTRK2_HUMANGRB10_HUMANBioGRID19166614 details
NTRK2_HUMANNMDZ1_HUMANBioGRID26253177 details
NTRK2_HUMANDYL1_HUMANHPRD11157096 details
NTRK2_HUMANFRS3_HUMANHPRD11432792 details
NTRK2_HUMANKDIS_HUMANHPRD15167895 details
NTRK2_HUMANPTN11_HUMANHPRD10386953 details
NTRK2_HUMANSH2B2_HUMANHPRD9856458 details
NTRK2_HUMANUBB_HUMANHPRD16701206 details
NTRK2_HUMANSHC2_HUMANHPRD12006576 9507002 details
NTRK2_HUMANRGRF1_HUMANHPRD15513915 details