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Entity Details
Primary name
MK06_HUMAN
Entity type
UniProt
Source
Source Link
Details
Accession
Q16659
EntryName
MK06_HUMAN
FullName
Mitogen-activated protein kinase 6
TaxID
9606
Evidence
evidence at protein level
Length
721
SequenceStatus
complete
DateCreated
1997-11-01
DateModified
2021-06-02
Ontological Relatives
Genes
MAPK6
GO terms
Show/Hide Table
GO
Name
GO:0004674
protein serine/threonine kinase activity
GO:0004707
MAP kinase activity
GO:0005524
ATP binding
GO:0005634
nucleus
GO:0005654
nucleoplasm
GO:0005737
cytoplasm
GO:0005829
cytosol
GO:0006468
protein phosphorylation
GO:0007049
cell cycle
GO:0007165
signal transduction
GO:0035556
intracellular signal transduction
GO:0106310
protein serine kinase activity
GO:0106311
protein threonine kinase activity
Subcellular Location
Show/Hide Table
Subcellular Location
Cytoplasm
Nucleus
Domains
Show/Hide Table
Domain
Name
Category
Type
IPR000719
Protein kinase domain
Domain
Domain
IPR008271
Serine/threonine-protein kinase, active site
Site
Active site
IPR008350
Mitogen-activated protein (MAP) kinase, ERK3/4
Family
Family
IPR011009
Protein kinase-like domain superfamily
Family
Homologous superfamily
IPR017441
Protein kinase, ATP binding site
Site
Binding site
Diseases
Show/Hide Table
Drugs
Show/Hide Table
Drug
Name
Source
Type
DB00945
Acetylsalicylic acid
Drugbank
small molecule
DB01017
Minocycline
Drugbank
small molecule
Interactions
175 interactions
Interactor
Partner
Sources
Publications
Link
MK06_HUMAN
ANK3_HUMAN
BioGRID, IntAct
20936779
details
MK06_HUMAN
CNTRL_HUMAN
BioGRID, IntAct
20936779
details
MK06_HUMAN
TCPG_HUMAN
BioGRID, IntAct
20936779
26972000
details
MK06_HUMAN
XPO2_HUMAN
BioGRID, IntAct
20936779
details
MK06_HUMAN
DYST_HUMAN
BioGRID, IntAct
20936779
details
MK06_HUMAN
CH60_HUMAN
BioGRID, IntAct
20936779
details
MK06_HUMAN
HS90B_HUMAN
BioGRID, IntAct
20936779
details
MK06_HUMAN
MAPK5_HUMAN
BioGRID, HPRD, IntAct, MINT
18720373
20936779
21900206
23602568
25416956
26972000
28514442
29426014
32296183
details
MK06_HUMAN
ENPL_HUMAN
BioGRID, IntAct
20936779
details
MK06_HUMAN
ZN600_HUMAN
BioGRID, IntAct
20936779
details
MK06_HUMAN
KDSR_HUMAN
BioGRID, IntAct
21988832
details
MK06_HUMAN
JUNB_HUMAN
BioGRID, IntAct
21988832
details
MK06_HUMAN
S20A1_HUMAN
BioGRID, IntAct
21988832
details
MK06_HUMAN
MBIP1_HUMAN
BioGRID, IntAct
21988832
details
MK06_HUMAN
GALT7_HUMAN
BioGRID, IntAct
21988832
details
MK06_HUMAN
EGLN3_HUMAN
BioGRID, IntAct
21988832
26972000
details
MK06_HUMAN
CCND3_HUMAN
BioGRID, IntAct
21988832
details
MK06_HUMAN
ACTG_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
ACTY_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
AMPH_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
APC5_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
APBA2_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
APOA1_HUMAN
BioGRID, IntAct, MINT
21900206
28514442
details
MK06_HUMAN
NNRE_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
GDIR1_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
ARPC3_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
ATG9A_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
ATP5J_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
BARX1_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
CREL2_HUMAN
MINT
21900206
details
MK06_HUMAN
BBS10_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
SKAP_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
CF298_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
CAH1_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
CAH12_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
CALR_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
CASP6_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
CAD13_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
HAUS2_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
COF1_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
CNTN1_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
NELFB_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
CSN6_HUMAN
BioGRID, MINT
21900206
26972000
details
MK06_HUMAN
CYH2_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
DREB_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
DCTN2_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
OST48_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
DDR1_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
DGKZ_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
DKC1_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
DJC28_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
DPPA4_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
VP26C_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
EDF1_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
EF1A2_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
EIF1_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
EIF3C_HUMAN
BioGRID, IntAct, MINT
21900206
29426014
details
MK06_HUMAN
IF4A1_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
ELOF1_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
EMD_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
CYRIB_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
FXL16_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
FOXO3_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
FXYD3_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
GATA1_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
GLRX3_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
RACK1_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
GORS1_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
GPX1_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
MTG2_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
HACL1_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
HDA11_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
HIP1_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
ROA0_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
HNRPD_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
HNRH3_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
IDH3B_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
INS_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
CENPR_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
ITSN1_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
KLC1_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
CERS1_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
LPXN_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
M3K12_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
M3K7_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
MASP1_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
MBOA7_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
MCM3_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
MK_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
MET17_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
MET2A_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
MGAT1_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
MZB1_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
MIPEP_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
MON1A_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
MYBB_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
MYOZ3_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
NAT9_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
NDUS6_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
NOL4_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
NRX2B_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
NUDT5_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
OSTF1_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
PDC6I_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
PDLI1_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
PHAR3_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
PHC2_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
SERA_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
PIHD1_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
PKHM1_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
PLK1_HUMAN
BioGRID, IntAct, MINT
21900206
26972000
29426014
details
MK06_HUMAN
PLS1_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
CXCL7_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
PP1R7_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
2AAA_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
AAKB1_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
KAP0_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
PR38A_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
SERC_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
PSIP1_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
PTPM1_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
NECT2_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
RAB2A_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
RAB31_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
MOK_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
RANB9_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
RPGP1_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
RARA_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
RBL1_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
RGS19_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
RL10_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
RRP7A_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
SEPT3_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
SEPT5_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
KAIN_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
SRSF5_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
SHC1_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
S41A3_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
SMAD6_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
SPSY_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
SNPC4_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
SNW1_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
SOCS3_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
SPG7_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
SPR2D_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
SPTN1_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
STX7_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
THAP4_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
TPIS_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
TTK_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
TYDP2_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
TBA1A_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
RL40_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
UB2L3_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
NPA1P_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
WDR26_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
DC2I2_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
WFS1_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
KIBRA_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
ZN133_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
ZN205_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
ZN331_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
ZN579_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
ZN671_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
ZN775_HUMAN
BioGRID, MINT
21900206
details
MK06_HUMAN
SUSD4_HUMAN
MINT
21900206
details
MK06_HUMAN
BAG6_HUMAN
BioGRID, IntAct
21900206
26972000
details
MK06_HUMAN
ANKR2_HUMAN
BioGRID, IntAct
32296183
details
MK06_HUMAN
NRX2A_HUMAN
BioGRID
21900206
details
MK06_HUMAN
UBP20_HUMAN
BioGRID
28167606
details
MK06_HUMAN
EF1D_HUMAN
IntAct
20195357
details
MK06_HUMAN
MK06_HUMAN
BioGRID, HPRD, IntAct
11741894
23602568
26972000
8621539
details
MK06_HUMAN
UBE3A_HUMAN
BioGRID, IntAct
22645313
26972000
29426014
details
MK06_HUMAN
KPCB_HUMAN
HPRD
8626698
details
MK06_HUMAN
XPO1_HUMAN
HPRD
12915405
details
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