Entity Details

Primary name PPARA
Entity type gene
Source Source Link

Details

PrimaryID5465
RefseqGeneNG_012204
SymbolPPARA
Nameperoxisome proliferator activated receptor alpha
Chromosome22
Location22q13.31
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1996-03-12
ModificationDate2021-06-22

Ontological Relatives

UniProt IDsPPARA_HUMAN

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001223 transcription coactivator binding
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001666 response to hypoxia
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0003707 steroid hormone receptor activity
GO:0004879 nuclear receptor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006631 fatty acid metabolic process
GO:0007507 heart development
GO:0008134 transcription factor binding
GO:0008144 drug binding
GO:0008270 zinc ion binding
GO:0008289 lipid binding
GO:0008544 epidermis development
GO:0009267 cellular response to starvation
GO:0009755 hormone-mediated signaling pathway
GO:0010565 regulation of cellular ketone metabolic process
GO:0010745 negative regulation of macrophage derived foam cell differentiation
GO:0010876 lipid localization
GO:0010887 negative regulation of cholesterol storage
GO:0010891 negative regulation of sequestering of triglyceride
GO:0019216 regulation of lipid metabolic process
GO:0019217 regulation of fatty acid metabolic process
GO:0019902 phosphatase binding
GO:0019904 protein domain specific binding
GO:0030154 cell differentiation
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0031624 ubiquitin conjugating enzyme binding
GO:0032000 positive regulation of fatty acid beta-oxidation
GO:0032091 negative regulation of protein binding
GO:0032099 negative regulation of appetite
GO:0032868 response to insulin
GO:0032922 circadian regulation of gene expression
GO:0033993 response to lipid
GO:0035095 behavioral response to nicotine
GO:0042060 wound healing
GO:0042157 lipoprotein metabolic process
GO:0042752 regulation of circadian rhythm
GO:0043565 sequence-specific DNA binding
GO:0044877 protein-containing complex binding
GO:0045070 positive regulation of viral genome replication
GO:0045471 response to ethanol
GO:0045722 positive regulation of gluconeogenesis
GO:0045776 negative regulation of blood pressure
GO:0045820 negative regulation of glycolytic process
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045923 positive regulation of fatty acid metabolic process
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046321 positive regulation of fatty acid oxidation
GO:0046889 positive regulation of lipid biosynthetic process
GO:0050728 negative regulation of inflammatory response
GO:0051525 NFAT protein binding
GO:0051898 negative regulation of protein kinase B signaling
GO:0061052 negative regulation of cell growth involved in cardiac muscle cell development
GO:0070166 enamel mineralization
GO:0097371 MDM2/MDM4 family protein binding
GO:1900016 negative regulation of cytokine production involved in inflammatory response
GO:1901215 negative regulation of neuron death
GO:1902894 negative regulation of pri-miRNA transcription by RNA polymerase II
GO:1903038 negative regulation of leukocyte cell-cell adhesion
GO:1903427 negative regulation of reactive oxygen species biosynthetic process
GO:1903944 negative regulation of hepatocyte apoptotic process
GO:2000191 regulation of fatty acid transport
GO:2000272 negative regulation of signaling receptor activity
GO:2001171 positive regulation of ATP biosynthetic process

Diseases

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Interactions

91 interactions

InteractorPartnerSourcesPublicationsLink
PPARANCOR2bhf-ucl, BioGRID, MINT11845213 19955185 details
PPARARXRGBioGRID, IntAct16169070 22205725 details
PPARACHD9BioGRID, UniProt16554032 details
PPARACDK3BioGRID, IntAct21988832 details
PPARAFOXA3BioGRID, IntAct21988832 details
PPARALAMTOR5BioGRID, IntAct23414517 details
PPARAPRMT8BioGRID, MINT23455924 details
PPARAPRMT1BioGRID, MINT23455924 details
PPARAUBE2Ibhf-ucl, BioGRID19955185 details
PPARANCOR1bhf-ucl, BioGRID, IntAct10336495 11903058 15870285 18292238 19955185 21775429 details
PPARAGRB2BioGRID, IntAct25814554 details
PPARAPIK3R3BioGRID, IntAct25814554 details
PPARANCOA1BioGRID, IntAct10731636 12163133 15888456 21775429 9407140 9626662 details
PPARAPPARGC1ABioGRID, IntAct10669761 21775429 details
PPARACREBBPIntAct21775429 details
PPARANCOA2BioGRID, IntAct15888456 21775429 details
PPARANR1H3BioGRID, DIP15722453 24713062 8621574 details
PPARANR1H2BioGRID, DIP15722453 details
PPARAALBIntAct32814053 details
PPARACASP6IntAct32814053 details
PPARACCKIntAct32814053 details
PPARAFGFR3IntAct32814053 details
PPARAGRIN2CIntAct32814053 details
PPARAGSNIntAct32814053 details
PPARALAMP2IntAct32814053 details
PPARARAD23AIntAct32814053 details
PPARARANIntAct32814053 details
PPARATGFBR2IntAct32814053 details
PPARAVCPIntAct32814053 details
PPARACBX5IntAct32814053 details
PPARAJPH3IntAct32814053 details
PPARASPRED1IntAct32814053 details
PPARAHTTIntAct32814053 details
PPARANRBF2BioGRID10786636 details
PPARASTAC3BioGRID16189514 32296183 details
PPARAGADD45GBioGRID10872826 details
PPARAEP300BioGRID10336495 18797151 9407140 details
PPARADAP3BioGRID10903152 details
PPARAFABP1BioGRID11226238 details
PPARAMECRBioGRID9795230 details
PPARARELABioGRID10542237 details
PPARANRIP1BioGRID9626662 details
PPARAPPARGC1BBioGRID11733490 details
PPARAAKAP13BioGRID9627117 details
PPARAPOU1F1BioGRID11891224 details
PPARAHELZ2BioGRID12189208 details
PPARARXRABioGRID10195690 12562861 15888456 22205725 23711995 details
PPARAMED24BioGRID9653119 details
PPARAHSP90AA1BioGRID12482853 12962497 details
PPARAAIPBioGRID12482853 details
PPARATNP1BioGRID21967852 details
PPARASIRT1BioGRID19356714 details
PPARANCOA3BioGRID15888456 details
PPARACEP350BioGRID15615782 details
PPARABCL2BioGRID26556865 details
PPARACDC34BioGRID26556865 details
PPARAPAQR3BioGRID29331071 details
PPARAHOXC8BioGRID32296183 details
PPARAFBLN1BioGRID32296183 details
PPARAPICK1BioGRID32296183 details
PPARACHIC2BioGRID32296183 details
PPARAVWA5ABioGRID32296183 details
PPARASDCBPBioGRID32296183 details
PPARACOL8A1BioGRID32296183 details
PPARAANKRD11BioGRID32296183 details
PPARAFAM90A1BioGRID32296183 details
PPARAVWC2LBioGRID32296183 details
PPARAFAM9BBioGRID32296183 details
PPARAEXOSC4BioGRID32296183 details
PPARACTNNA3BioGRID32296183 details
PPARAZSCAN23BioGRID32296183 details
PPARAZNF587BioGRID32296183 details
PPARAGPANK1BioGRID32296183 details
PPARAKRTAP10-1BioGRID32296183 details
PPARAAQP1BioGRID32296183 details
PPARAKCTD7BioGRID32296183 details
PPARACCDC179BioGRID32296183 details
PPARATRIM55BioGRID31391242 details
PPARATRIM63BioGRID31391242 details
PPARAPRMT2IntAct12039952 details
PPARAMED1UniProt9653119 details
PPARALPIN1BioGRID20385772 details
PPARARXRBBioGRID22205725 details
PPARASTAT1BioGRID26504087 details
PPARAHUWE1BioGRID29331071 details
PPARAVHLBioGRID32589900 details
PPARAZDHHC18BioGRID30658672 details
PPARAZDHHC23BioGRID30658672 details
PPARAIL17FIntAct33179750 details
PPARAHNRNPLBioGRID28611215 details
PPARAVIRMABioGRID29507755 details