Entity Details

Primary name MICA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ29983
EntryNameMICA_HUMAN
FullNameMHC class I polypeptide-related sequence A
TaxID9606
Evidenceevidence at protein level
Length383
SequenceStatuscomplete
DateCreated2008-05-20
DateModified2021-06-02

Ontological Relatives

GenesMICA

GO terms

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GOName
GO:0001913 T cell mediated cytotoxicity
GO:0002418 immune response to tumor cell
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006974 cellular response to DNA damage stimulus
GO:0009408 response to heat
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016032 viral process
GO:0019835 cytolysis
GO:0032815 negative regulation of natural killer cell activation
GO:0042267 natural killer cell mediated cytotoxicity
GO:0042742 defense response to bacterium
GO:0045953 negative regulation of natural killer cell mediated cytotoxicity
GO:0046629 gamma-delta T cell activation
GO:0046703 natural killer cell lectin-like receptor binding
GO:0050776 regulation of immune response
GO:0051607 defense response to virus

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm

Domains

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DomainNameCategoryType
IPR003597 Immunoglobulin C1-setDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR011161 MHC class I-like antigen recognition-likeDomainDomain
IPR011162 MHC classes I/II-like antigen recognition proteinFamilyHomologous superfamily
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily
IPR037055 MHC class I-like antigen recognition-like superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
177900 OMIMPsoriasis 1 (PSORS1)A common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis. Disease susceptibility is associated with variants affecting the gene represented in this entry.
607507 OMIMPsoriatic arthritis (PSORAS)An inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoid like pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis). Disease susceptibility is associated with variants affecting the gene represented in this entry.

Interactions

4 interactions