Entity Details

Primary name BCL2
Entity type gene
Source Source Link

Details

PrimaryID596
RefseqGeneNG_009361
SymbolBCL2
NameBCL2 apoptosis regulator
Chromosome18
Location18q21.33
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1993-11-10
ModificationDate2021-06-20

Ontological Relatives

UniProt IDsBCL2_HUMAN

GO terms

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GOName
GO:0000209 protein polyubiquitination
GO:0001503 ossification
GO:0001541 ovarian follicle development
GO:0001656 metanephros development
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001662 behavioral fear response
GO:0001782 B cell homeostasis
GO:0001836 release of cytochrome c from mitochondria
GO:0001952 regulation of cell-matrix adhesion
GO:0002020 protease binding
GO:0002320 lymphoid progenitor cell differentiation
GO:0002326 B cell lineage commitment
GO:0002931 response to ischemia
GO:0003014 renal system process
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0006470 protein dephosphorylation
GO:0006582 melanin metabolic process
GO:0006808 regulation of nitrogen utilization
GO:0006915 apoptotic process
GO:0006959 humoral immune response
GO:0006974 cellular response to DNA damage stimulus
GO:0007015 actin filament organization
GO:0007409 axonogenesis
GO:0007565 female pregnancy
GO:0007569 cell aging
GO:0008284 positive regulation of cell population proliferation
GO:0008584 male gonad development
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0009314 response to radiation
GO:0009636 response to toxic substance
GO:0009791 post-embryonic development
GO:0010039 response to iron ion
GO:0010224 response to UV-B
GO:0010332 response to gamma radiation
GO:0010468 regulation of gene expression
GO:0010507 negative regulation of autophagy
GO:0010523 negative regulation of calcium ion transport into cytosol
GO:0010559 regulation of glycoprotein biosynthetic process
GO:0014031 mesenchymal cell development
GO:0014042 positive regulation of neuron maturation
GO:0014911 positive regulation of smooth muscle cell migration
GO:0015267 channel activity
GO:0016020 membrane
GO:0016248 channel inhibitor activity
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0019221 cytokine-mediated signaling pathway
GO:0021747 cochlear nucleus development
GO:0022612 gland morphogenesis
GO:0022898 regulation of transmembrane transporter activity
GO:0030279 negative regulation of ossification
GO:0030307 positive regulation of cell growth
GO:0030308 negative regulation of cell growth
GO:0030318 melanocyte differentiation
GO:0030336 negative regulation of cell migration
GO:0030890 positive regulation of B cell proliferation
GO:0031069 hair follicle morphogenesis
GO:0031103 axon regeneration
GO:0031625 ubiquitin protein ligase binding
GO:0031647 regulation of protein stability
GO:0031965 nuclear membrane
GO:0032469 endoplasmic reticulum calcium ion homeostasis
GO:0032835 glomerulus development
GO:0032848 negative regulation of cellular pH reduction
GO:0032991 protein-containing complex
GO:0033033 negative regulation of myeloid cell apoptotic process
GO:0033077 T cell differentiation in thymus
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0033689 negative regulation of osteoblast proliferation
GO:0034097 response to cytokine
GO:0035094 response to nicotine
GO:0035265 organ growth
GO:0040018 positive regulation of multicellular organism growth
GO:0042100 B cell proliferation
GO:0042149 cellular response to glucose starvation
GO:0042493 response to drug
GO:0042542 response to hydrogen peroxide
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043029 T cell homeostasis
GO:0043066 negative regulation of apoptotic process
GO:0043085 positive regulation of catalytic activity
GO:0043209 myelin sheath
GO:0043375 CD8-positive, alpha-beta T cell lineage commitment
GO:0043524 negative regulation of neuron apoptotic process
GO:0043565 sequence-specific DNA binding
GO:0043583 ear development
GO:0045069 regulation of viral genome replication
GO:0045636 positive regulation of melanocyte differentiation
GO:0046671 negative regulation of retinal cell programmed cell death
GO:0046902 regulation of mitochondrial membrane permeability
GO:0046930 pore complex
GO:0046982 protein heterodimerization activity
GO:0048041 focal adhesion assembly
GO:0048536 spleen development
GO:0048538 thymus development
GO:0048546 digestive tract morphogenesis
GO:0048599 oocyte development
GO:0048743 positive regulation of skeletal muscle fiber development
GO:0048753 pigment granule organization
GO:0048873 homeostasis of number of cells within a tissue
GO:0050853 B cell receptor signaling pathway
GO:0051384 response to glucocorticoid
GO:0051402 neuron apoptotic process
GO:0051434 BH3 domain binding
GO:0051607 defense response to virus
GO:0051721 protein phosphatase 2A binding
GO:0051881 regulation of mitochondrial membrane potential
GO:0051902 negative regulation of mitochondrial depolarization
GO:0051924 regulation of calcium ion transport
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0071456 cellular response to hypoxia
GO:0072593 reactive oxygen species metabolic process
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:0098609 cell-cell adhesion
GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle
GO:2000378 negative regulation of reactive oxygen species metabolic process
GO:2000811 negative regulation of anoikis
GO:2001234 negative regulation of apoptotic signaling pathway
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway

Diseases

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Interactions

140 interactions

InteractorPartnerSourcesPublicationsLink
BCL2BAXBioGRID, DIP, HPRD, IntAct, MINT10620799 10716992 14980220 15231068 15899854 16642033 17097560 17289999 17525735 18981409 21199865 21458670 21671007 21778226 22262057 23479509 24141421 26004684 29749471 32064756 8358790 9111042 9388232 9463381 details
BCL2BADBioGRID, HPRD, IntAct, MINT10611223 11483855 15694340 15849194 15990872 16697956 17446862 19168699 20603619 7834748 9305851 9388232 9463381 details
BCL2BCL2L11BioGRID, HPRD, IntAct, MINT10198631 15694340 15899854 16697956 17074758 17097560 17289999 17692808 19805519 20836993 21199865 21671007 23845444 26004684 26186194 28514442 9430630 9463381 9731710 details
BCL2BNIP2BioGRID, HPRD, MINT10381623 12901880 7954800 details
BCL2BECN1BioGRID, DIP, HPRD, IntAct, matrixdb, MINT16179260 17446862 18641390 19050071 19180116 19347031 19959994 20010695 20577262 20622903 20711182 20889974 21139567 21358617 21543763 21971985 22082873 22241963 22498477 22622204 23168911 23316280 23479509 23504944 23541952 23564079 23822101 23954414 24034250 24141421 24472739 24599950 24879154 25891078 25984893 27304906 28128446 28431397 28682313 29079782 29849149 29955058 31410188 31696776 32097085 32820146 9765397 details
BCL2BCL2L1BioGRID, HPRD, IntAct11583631 12137781 14980220 18835031 26186194 28514442 details
BCL2PSEN1BioGRID, HPRD10521466 15905180 details
BCL2BFARBioGRID, HPRD10716992 details
BCL2XIAPBioGRID29020630 details
BCL2BCL2L12BioGRID29749471 details
BCL2BCAP31BioGRID, HPRD, IntAct31206022 9334338 details
BCL2MAPK1BioGRID, HPRD, MINT10567572 12039864 15225643 details
BCL2PPP2CABioGRID, HPRD, MINT15225643 9852076 details
BCL2FKBP8BioGRID, HPRD, MINT12510191 15733859 15905180 15990872 17379601 17942410 details
BCL2BAK1BioGRID, HPRD, IntAct11206074 11728179 14980220 20836993 26004684 32064756 9463381 details
BCL2BIKBioGRID, HPRD, IntAct12853473 15694340 16697956 17289999 31387940 32296183 9463381 9488477 9525867 details
BCL2BNIP3BioGRID, HPRD, MINT10381623 10625696 23504944 7954800 details
BCL2PPP1CABioGRID, HPRD, IntAct11390485 17274640 details
BCL2TP53BioGRID, HPRD, IntAct, MINT12667443 16443602 19521340 21597459 21624955 23316052 30683842 32064756 details
BCL2RTN4BioGRID, HPRD11126360 17191123 details
BCL2SEPTIN4BioGRID29020630 details
BCL2BIDBioGRID, DIP, HPRD, IntAct11583631 12624108 15520201 15694340 16697956 17289999 18835031 19074266 9463381 9727491 details
BCL2NR4A1BioGRID, HPRD, IntAct14980220 16434970 18835031 details
BCL2PMAIP1BioGRID, HPRD, IntAct10807576 15694340 21454712 details
BCL2PPIFUniProt19228691 details
BCL2RRASBioGRID, HPRD8232588 details
BCL2CDK1BioGRID11326318 11774038 9668078 details
BCL2BNIP1BioGRID, HPRD10217402 details
BCL2PPIDBioGRID19228691 details
BCL2BBC3BioGRID, HPRD, IntAct11463392 15694340 16697956 17289999 26431330 details
BCL2BNIP3LBioGRID, HPRD, IntAct10467396 9973195 details
BCL2CASP8BioGRID, HPRD, IntAct11406564 16183855 details
BCL2AMBRA1BioGRID, MINT21358617 details
BCL2BRCA1BioGRID, IntAct21444675 details
BCL2SOD1BioGRID, HPRD, IntAct15233914 32814053 details
BCL2BNIPLBioGRID, HPRD12901880 details
BCL2MAPK8BioGRID, HPRD, MINT10567572 12039864 15225643 15733859 details
BCL2BCL2BioGRID, HPRD, IntAct15302859 18835031 9111042 9463381 details
BCL2SMN1BioGRID, HPRD9389483 details
BCL2ITPR1BioGRID, DIP, HPRD15613488 19706527 details
BCL2HRKBioGRID, HPRD10075695 15694340 9130713 details
BCL2RAF1BioGRID, HPRD12488548 15849194 8910675 8929532 details
BCL2CISD2BioGRID, MINT20010695 details
BCL2TP53BP2BioGRID, DIP, HPRD18719108 8668206 details
BCL2CAPN2BioGRID12000759 details
BCL2NLRP1DIP, HPRD, IntAct17418785 19223583 details
BCL2BMFBioGRID, HPRD, IntAct11546872 16697956 17289999 details
BCL2LRRK2IntAct25446991 details
BCL2BLKBioGRID, HPRD9525867 details
BCL2RAD9ABioGRID, HPRD10620799 18794804 details
BCL2PPARABioGRID26556865 details
BCL2APPIntAct32814053 details
BCL2CASP3BioGRID, HPRD11752215 11948397 9395403 details
BCL2PRKNBioGRID20889974 32929329 details
BCL2SPHK2BioGRID28682313 details
BCL2MEX3DBioGRID14769789 details
BCL2TOMM20BioGRID, HPRD9119086 details
BCL2HNRNPDBioGRID14769789 details
BCL2PPP3CCBioGRID15757646 details
BCL2PPP3R1MINT15757646 details
BCL2PPP1CBBioGRID, IntAct17274640 details
BCL2SQSTM1BioGRID23564079 25311206 details
BCL2PARP1BioGRID, HPRD11790116 details
BCL2RNF183BioGRID29507230 details
BCL2CPT1AHPRD9070836 details
BCL2PPP1CCBioGRID, IntAct17274640 details
BCL2BAG1BioGRID, HPRD9305631 details
BCL2VRK2IntAct16963744 details
BCL2BCLAF1HPRD, IntAct10330179 23541952 details
BCL2AVENBioGRID10949025 details
BCL2TP53AIP1BioGRID, HPRD12019168 details
BCL2PIN1BioGRID, HPRD11326318 11988841 details
BCL2PPP2R5ABioGRID, HPRD11929874 details
BCL2PPP3CABioGRID, HPRD19706527 7593193 9109491 details
BCL2HSP90AA1BioGRID20668552 21543763 details
BCL2PSEN2BioGRID15905180 details
BCL2FAIM2BioGRID26582200 details
BCL2PRKACAHPRD11158204 7929424 9115213 details
BCL2PMLBioGRID, HPRD15231068 details
BCL2SPNS1BioGRID, HPRD, UniProt12815463 details
BCL2SERPINB8BioGRID15231068 details
BCL2VDAC1BioGRID19706527 details
BCL2HSPA1ABioGRID, HPRD10354271 details
BCL2TMBIM6BioGRID, HPRD9660918 details
BCL2ATP2A2HPRD9788433 details
BCL2PXNHPRD10417825 details
BCL2PKMYT1HPRD11326318 details
BCL2BCL2L10BioGRID, HPRD11278245 details
BCL2ITM2BBioGRID, HPRD12082633 details
BCL2PRKCAHPRD9738012 details
BCL2SIVA1UniProt14739602 details
BCL2MDM4BioGRID, MINT19521340 24445145 details
BCL2BLIDBioGRID20400521 details
BCL2IRS1BioGRID10679027 details
BCL2CYCSHPRD10622714 details
BCL2MAPK11HPRD11495898 details
BCL2IRS2BioGRID10679027 details
BCL2KRASBioGRID, HPRD10490827 19433448 details
BCL2NRASHPRD10490827 details
BCL2SF1HPRD8668206 details
BCL2BECN2IntAct23954414 details
BCL2HIF1ABioGRID20668552 23836782 details
BCL2CDK2BioGRID, HPRD15619620 details
BCL2UBE2IBioGRID26416353 details
BCL2BAG4HPRD11527400 details
BCL2MOAP1BioGRID, HPRD11060313 details
BCL2KEAP1BioGRID30126895 details
BCL2MAPK3HPRD10677502 details
BCL2HRASHPRD10490827 details
BCL2BCL2L14HPRD11054413 details
BCL2NR4A3MINT30455429 details
BCL2IKBKBBioGRID22262057 details
BCL2LRPPRCBioGRID23822101 details
BCL2ATG12BioGRID22152474 details
BCL2CHUKBioGRID22262057 details
BCL2DYNLL1BioGRID10198631 details
BCL2ATP2A3BioGRID9788433 details
BCL2NMT2BioGRID, HPRD, MINT16530191 details
BCL2RTL10IntAct23055042 details
BCL2CRYABBioGRID20841355 details
BCL2RTN3BioGRID17191123 details
BCL2MAPK14HPRD11495898 details
BCL2IKBKGBioGRID17363905 details
BCL2BAG3BioGRID, HPRD11513873 23341456 details
BCL2BARD1BioGRID26022179 details
BCL2MYCBioGRID, HPRD15210690 details
BCL2GIMAP5BioGRID16509771 details
BCL2MAT2ABioGRID26416353 details
BCL2ITPR3BioGRID15613488 details
BCL2CALRMINT21139567 details
BCL2HSPA9MINT21139567 details
BCL2MCL1MINT21139567 details
BCL2CUL4ABioGRID30945288 details
BCL2CEBPAIntAct23814099 details
BCL2TNIP2BioGRID27609421 details
BCL2IER3IntAct18191642 details
BCL2VIRMABioGRID29507755 details
BCL2BRD2IntAct23791182 details
BCL2BRD4IntAct23791182 details
BCL2RELAIntAct18191642 details