Entity Details

Primary name GRDN_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ3V6T2
EntryNameGRDN_HUMAN
FullNameGirdin
TaxID9606
Evidenceevidence at protein level
Length1871
SequenceStatuscomplete
DateCreated2007-05-15
DateModified2021-06-02

Ontological Relatives

GenesCCDC88A

GO terms

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GOName
GO:0001932 regulation of protein phosphorylation
GO:0001965 G-protein alpha-subunit binding
GO:0003779 actin binding
GO:0005080 protein kinase C binding
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005092 GDP-dissociation inhibitor activity
GO:0005154 epidermal growth factor receptor binding
GO:0005158 insulin receptor binding
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005813 centrosome
GO:0005814 centriole
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006260 DNA replication
GO:0006275 regulation of DNA replication
GO:0007264 small GTPase mediated signal transduction
GO:0007399 nervous system development
GO:0008017 microtubule binding
GO:0010975 regulation of neuron projection development
GO:0016020 membrane
GO:0016477 cell migration
GO:0030027 lamellipodium
GO:0030032 lamellipodium assembly
GO:0030142 COPI-coated Golgi to ER transport vesicle
GO:0030705 cytoskeleton-dependent intracellular transport
GO:0031122 cytoplasmic microtubule organization
GO:0031410 cytoplasmic vesicle
GO:0031682 G-protein gamma-subunit binding
GO:0031929 TOR signaling
GO:0032147 activation of protein kinase activity
GO:0032148 activation of protein kinase B activity
GO:0032956 regulation of actin cytoskeleton organization
GO:0035091 phosphatidylinositol binding
GO:0036064 ciliary basal body
GO:0042127 regulation of cell population proliferation
GO:0042169 SH2 domain binding
GO:0042803 protein homodimerization activity
GO:0043184 vascular endothelial growth factor receptor 2 binding
GO:0043422 protein kinase B binding
GO:0045724 positive regulation of cilium assembly
GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway
GO:0051496 positive regulation of stress fiber assembly
GO:0051959 dynein light intermediate chain binding
GO:0061024 membrane organization
GO:0072660 maintenance of protein location in plasma membrane
GO:1903566 positive regulation of protein localization to cilium

Subcellular Location

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Subcellular Location
Cell membrane
Cell projection
Cytoplasm
Cytoplasmic vesicle

Domains

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DomainNameCategoryType
IPR001715 Calponin homology domainDomainDomain
IPR027717 GirdinFamilyFamily
IPR036872 CH domain superfamilyFamilyHomologous superfamily
IPR043936 HOOK, N-terminalDomainDomain

Diseases

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Interactions

33 interactions

InteractorPartnerSourcesPublicationsLink
GRDN_HUMANDISC1_HUMANBioGRID, IntAct17043677 31413325 details
GRDN_HUMANNDEL1_HUMANBioGRID, IntAct17043677 31413325 details
GRDN_HUMANBRAF_HUMANBioGRID, IntAct20936779 details
GRDN_HUMANKAPCA_HUMANBioGRID, IntAct20936779 details
GRDN_HUMANHD_HUMANIntAct17500595 details
GRDN_HUMANEXOC1_HUMANBioGRID, IntAct17043677 31413325 details
GRDN_HUMANAKT1_HUMANBioGRID, HPRD15753085 16139227 details
GRDN_HUMANGNAI3_HUMANBioGRID21209316 25187647 26186194 details
GRDN_HUMANEGFR_HUMANBioGRID15882442 25187647 details
GRDN_HUMANPTN6_HUMANBioGRID21799016 details
GRDN_HUMANVGFR2_HUMANBioGRID25187647 details
GRDN_HUMANINSR_HUMANBioGRID25187647 details
GRDN_HUMANAAKB1_HUMANIntAct17353931 details
GRDN_HUMANPPARG_HUMANIntAct20195357 details
GRDN_HUMANVIP2_HUMANBioGRID, IntAct27173435 unassigned1312 details
GRDN_HUMANSC24B_HUMANBioGRID, IntAct27173435 unassigned1312 details
GRDN_HUMANUB2D2_HUMANBioGRID, IntAct27173435 unassigned1312 details
GRDN_HUMANPLEC_HUMANBioGRID, IntAct27173435 unassigned1312 details
GRDN_HUMANAAK1_HUMANBioGRID, IntAct27173435 unassigned1312 details
GRDN_HUMANQSER1_HUMANBioGRID, IntAct27173435 unassigned1312 details
GRDN_HUMANEYA4_HUMANBioGRID, IntAct27173435 unassigned1312 details
GRDN_HUMANLUZP1_HUMANBioGRID, IntAct27173435 unassigned1312 details
GRDN_HUMANURGCP_HUMANBioGRID, IntAct27173435 unassigned1312 details
GRDN_HUMANDVL3_HUMANBioGRID, IntAct27173435 unassigned1312 details
GRDN_HUMANNUP88_HUMANBioGRID, IntAct27173435 unassigned1312 details
GRDN_HUMANFMR1_HUMANIntAct31413325 details
GRDN_HUMANMT21A_HUMANBioGRID23349634 details
GRDN_HUMANMT21C_HUMANBioGRID23349634 details
GRDN_HUMANGRDN_HUMANBioGRID16139227 details
GRDN_HUMANSNX1_HUMANBioGRID15882442 details
GRDN_HUMANHEY1_HUMANBioGRID27129302 details
GRDN_HUMANDYHC1_HUMANBioGRID28718761 details
GRDN_HUMANDCTN1_HUMANBioGRID28718761 details