Entity Details

Primary name TGFBR2
Entity type gene
Source Source Link

Details

PrimaryID7048
RefseqGeneNG_007490
SymbolTGFBR2
Nametransforming growth factor beta receptor 2
Chromosome3
Location3p24.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1994-04-20
ModificationDate2021-06-13

Ontological Relatives

UniProt IDsTGFR2_HUMAN

GO terms

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GOName
GO:0001568 blood vessel development
GO:0001569 branching involved in blood vessel morphogenesis
GO:0001570 vasculogenesis
GO:0001666 response to hypoxia
GO:0001701 in utero embryonic development
GO:0001947 heart looping
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0002088 lens development in camera-type eye
GO:0002651 positive regulation of tolerance induction to self antigen
GO:0002663 positive regulation of B cell tolerance induction
GO:0002666 positive regulation of T cell tolerance induction
GO:0003148 outflow tract septum morphogenesis
GO:0003149 membranous septum morphogenesis
GO:0003151 outflow tract morphogenesis
GO:0003181 atrioventricular valve morphogenesis
GO:0003186 tricuspid valve morphogenesis
GO:0003214 cardiac left ventricle morphogenesis
GO:0003274 endocardial cushion fusion
GO:0003430 growth plate cartilage chondrocyte growth
GO:0004674 protein serine/threonine kinase activity
GO:0004675 transmembrane receptor protein serine/threonine kinase activity
GO:0005024 transforming growth factor beta-activated receptor activity
GO:0005026 transforming growth factor beta receptor activity, type II
GO:0005524 ATP binding
GO:0005539 glycosaminoglycan binding
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005901 caveola
GO:0006468 protein phosphorylation
GO:0006898 receptor-mediated endocytosis
GO:0006915 apoptotic process
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007182 common-partner SMAD protein phosphorylation
GO:0007219 Notch signaling pathway
GO:0007224 smoothened signaling pathway
GO:0007369 gastrulation
GO:0007420 brain development
GO:0007507 heart development
GO:0007566 embryo implantation
GO:0007568 aging
GO:0007584 response to nutrient
GO:0008284 positive regulation of cell population proliferation
GO:0009612 response to mechanical stimulus
GO:0009749 response to glucose
GO:0009897 external side of plasma membrane
GO:0010468 regulation of gene expression
GO:0010634 positive regulation of epithelial cell migration
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0016021 integral component of membrane
GO:0017002 activin-activated receptor activity
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0031100 animal organ regeneration
GO:0031435 mitogen-activated protein kinase kinase kinase binding
GO:0032147 activation of protein kinase activity
GO:0034713 type I transforming growth factor beta receptor binding
GO:0034714 type III transforming growth factor beta receptor binding
GO:0035162 embryonic hemopoiesis
GO:0042060 wound healing
GO:0042127 regulation of cell population proliferation
GO:0042493 response to drug
GO:0043011 myeloid dendritic cell differentiation
GO:0043235 receptor complex
GO:0043415 positive regulation of skeletal muscle tissue regeneration
GO:0043627 response to estrogen
GO:0045121 membrane raft
GO:0045766 positive regulation of angiogenesis
GO:0046332 SMAD binding
GO:0046872 metal ion binding
GO:0048185 activin binding
GO:0048545 response to steroid hormone
GO:0048565 digestive tract development
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0050431 transforming growth factor beta binding
GO:0051138 positive regulation of NK T cell differentiation
GO:0060044 negative regulation of cardiac muscle cell proliferation
GO:0060389 pathway-restricted SMAD protein phosphorylation
GO:0060412 ventricular septum morphogenesis
GO:0060434 bronchus morphogenesis
GO:0060440 trachea formation
GO:0060443 mammary gland morphogenesis
GO:0060463 lung lobe morphogenesis
GO:0062009 secondary palate development
GO:0070723 response to cholesterol
GO:0071363 cellular response to growth factor stimulus
GO:1905007 positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
GO:1905317 inferior endocardial cushion morphogenesis
GO:1990086 lens fiber cell apoptotic process
GO:1990428 miRNA transport
GO:2000379 positive regulation of reactive oxygen species metabolic process
GO:2000563 positive regulation of CD4-positive, alpha-beta T cell proliferation

Diseases

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Interactions

251 interactions

InteractorPartnerSourcesPublicationsLink
TGFBR2DAXXBioGRID, MINT11483955 details
TGFBR2TGFB3BioGRID, HPRD, IntAct, MINT11157754 11382746 11850637 12729750 21423151 8106553 9872992 details
TGFBR2TGFB1BioGRID, HPRD, I2D, MINT11157754 20856203 20860622 21054789 21441952 7935686 8242742 8389764 details
TGFBR2FSTL1MINT20860622 details
TGFBR2PDGFRABioGRID, IntAct21988832 details
TGFBR2RCVRNBioGRID, IntAct21988832 details
TGFBR2GOPCBioGRID, IntAct21988832 details
TGFBR2SCUBE3I2D21441952 details
TGFBR2TRMOBioGRID, MINT24412244 details
TGFBR2FANCCBioGRID, MINT24412244 details
TGFBR2MAP2K1BioGRID, MINT24412244 details
TGFBR2PPP2CBBioGRID, MINT24412244 details
TGFBR2ZNF510BioGRID, MINT24412244 details
TGFBR2SP6IntAct19088080 32814053 details
TGFBR2LRG1DIP23868260 details
TGFBR2TGFBR1BioGRID, DIP, HPRD11102446 11483955 19556242 19758997 21791611 23868260 25825445 7890683 8576253 details
TGFBR2GPM6AIntAct32814053 details
TGFBR2IDH1IntAct32814053 details
TGFBR2ETS2IntAct32814053 details
TGFBR2ELAVL4IntAct32814053 details
TGFBR2DNASE1L1IntAct32814053 details
TGFBR2CSNK1DIntAct32814053 details
TGFBR2AP1S1IntAct32814053 details
TGFBR2CDH1IntAct32814053 details
TGFBR2CCT6AIntAct32814053 details
TGFBR2ATP2A3IntAct32814053 details
TGFBR2AK2IntAct32814053 details
TGFBR2MYCIntAct32814053 details
TGFBR2KELIntAct32814053 details
TGFBR2STT3AIntAct32814053 details
TGFBR2ITGAVIntAct32814053 details
TGFBR2GNAO1IntAct32814053 details
TGFBR2RAPSNIntAct32814053 details
TGFBR2NELL2IntAct32814053 details
TGFBR2PSMD2IntAct32814053 details
TGFBR2PPARAIntAct32814053 details
TGFBR2PTNIntAct32814053 details
TGFBR2FAM104AIntAct32814053 details
TGFBR2RILPIntAct32814053 details
TGFBR2TRAF3IP3IntAct32814053 details
TGFBR2MAVSIntAct32814053 details
TGFBR2ISY1-RAB43IntAct32814053 details
TGFBR2ISY1IntAct32814053 details
TGFBR2RHBDD2IntAct32814053 details
TGFBR2MYNNIntAct32814053 details
TGFBR2NPLOC4BioGRID, IntAct28443643 32814053 details
TGFBR2PIGVIntAct32814053 details
TGFBR2NSD3IntAct32814053 details
TGFBR2PLPPR1IntAct32814053 details
TGFBR2USP25IntAct32814053 details
TGFBR2ARFGAP3IntAct32814053 details
TGFBR2SERBP1IntAct32814053 details
TGFBR2NSL1IntAct32814053 details
TGFBR2BAHD1IntAct32814053 details
TGFBR2DDX19BIntAct32814053 details
TGFBR2KLK8IntAct32814053 details
TGFBR2SNRNP35IntAct32814053 details
TGFBR2DPYSL4IntAct32814053 details
TGFBR2SIGMAR1IntAct32814053 details
TGFBR2MFSD10IntAct32814053 details
TGFBR2KLRG1IntAct32814053 details
TGFBR2RBM5IntAct32814053 details
TGFBR2ATG13IntAct32814053 details
TGFBR2PCSK7IntAct32814053 details
TGFBR2YY1IntAct32814053 details
TGFBR2WT1IntAct32814053 details
TGFBR2TCOF1IntAct32814053 details
TGFBR2SUV39H1IntAct32814053 details
TGFBR2SGCAIntAct32814053 details
TGFBR2RPL37AIntAct32814053 details
TGFBR2LNX2IntAct32814053 details
TGFBR2SNX20IntAct32814053 details
TGFBR2TRIM43IntAct32814053 details
TGFBR2C1orf216IntAct32814053 details
TGFBR2INO80CIntAct32814053 details
TGFBR2SLC44A5IntAct32814053 details
TGFBR2ATXN3IntAct32814053 details
TGFBR2HTTIntAct32814053 details
TGFBR2ATXN1IntAct32814053 details
TGFBR2CLUBioGRID, HPRD8555189 details
TGFBR2ENGBioGRID, HPRD12015308 15702480 9872992 details
TGFBR2AP2B1BioGRID, HPRD12429842 details
TGFBR2CCNB2BioGRID, HPRD9926943 details
TGFBR2CCNB1BioGRID, HPRD9926943 details
TGFBR2STRAPBioGRID, HPRD10757800 9856985 details
TGFBR2ACVR1BioGRID7890683 details
TGFBR2HSP90AA1BioGRID18591668 22848678 details
TGFBR2TRAF6BioGRID18922473 26807171 details
TGFBR2PAK1BioGRID, HPRD15761153 details
TGFBR2APPBioGRID21244100 21832049 details
TGFBR2NRP1BioGRID20675371 21186301 details
TGFBR2TERTBioGRID23741361 details
TGFBR2CBLBioGRID23290524 31315051 details
TGFBR2TDGF1BioGRID28126904 details
TGFBR2PSMD14BioGRID28443643 30745168 31685442 details
TGFBR2USP2BioGRID29490279 details
TGFBR2TGFBR2HPRD11163210 11279102 7890683 details
TGFBR2DYNLT4HPRD16982625 details
TGFBR2SHC1MINT17440088 details
TGFBR2MED12IntAct23178117 details
TGFBR2MARCHF7BioGRID, IntAct26186194 28514442 29794480 details
TGFBR2PIK3R1BioGRID, HPRD, IntAct26186194 28514442 9435577 details
TGFBR2PIK3R2BioGRID, HPRD, IntAct26186194 28514442 9435577 details
TGFBR2ACVRL1DIP, HPRD10716993 23868260 details
TGFBR2ACE2UniProt26867007 details
TGFBR2SMURF2BioGRID11163210 25149540 details
TGFBR2SMAD7BioGRID, HPRD11163210 25149540 9335507 details
TGFBR2CTNNB1BioGRID, HPRD12000714 details
TGFBR2TGFBR3BioGRID, HPRD11323414 8106553 details
TGFBR2TGFB2BioGRID, HPRD11157754 8106553 details
TGFBR2SNX6BioGRID, HPRD11279102 details
TGFBR2SMURF1BioGRID11278251 27048878 details
TGFBR2TSC22D1BioGRID21791611 details
TGFBR2MAP3K7BioGRID19556242 details
TGFBR2CDC42BioGRID15761153 details
TGFBR2ARHGEF6BioGRID, HPRD15761153 details
TGFBR2KCNK18BioGRID, HPRD15761153 details
TGFBR2FBXO34BioGRID15761153 details
TGFBR2OXSR1BioGRID15761153 details
TGFBR2PPP1R16BBioGRID15761153 details
TGFBR2OCLNBioGRID15761153 details
TGFBR2IQGAP1BioGRID23454766 details
TGFBR2PEG10BioGRID15611116 details
TGFBR2NRP2BioGRID21186301 details
TGFBR2TRAF4BioGRID23973329 details
TGFBR2SPSB1BioGRID26032413 details
TGFBR2EIF3IBioGRID, HPRD11781097 7566156 9813058 details
TGFBR2TGFBRAP1BioGRID, HPRD11278302 details
TGFBR2SH3KBP1BioGRID26169354 details
TGFBR2RASSF1BioGRID27292796 details
TGFBR2FAF1BioGRID28443643 details
TGFBR2VCPBioGRID28443643 details
TGFBR2UFD1BioGRID28443643 details
TGFBR2BTRCBioGRID28443643 details
TGFBR2CUL1BioGRID28443643 details
TGFBR2CAV1BioGRID30745168 details
TGFBR2CD44HPRD12145287 details
TGFBR2TGFB1I1HPRD12421567 details
TGFBR2ZFYVE9HPRD9865696 details
TGFBR2PMLHPRD15356634 details
TGFBR2SMAD4HPRD8774881 details
TGFBR2SMAD3HPRD8774881 details
TGFBR2CDK1HPRD9926943 details
TGFBR2TRAP1HPRD11278302 details
TGFBR2TSSK1BHPRD15761153 details
TGFBR2ARHGEF7HPRD15761153 details
TGFBR2OSR1HPRD15761153 details
TGFBR2DAB2BioGRID, HPRD, UniProt11387212 details
TGFBR2FMN2BioGRID, IntAct26186194 28514442 details
TGFBR2RAB6BBioGRID, IntAct26186194 28514442 details
TGFBR2NDFIP1BioGRID, IntAct26186194 28514442 details
TGFBR2CDC6BioGRID, IntAct26186194 28514442 details
TGFBR2MYADMBioGRID, IntAct26186194 28443643 28514442 details
TGFBR2RELTBioGRID, IntAct26186194 28514442 details
TGFBR2PIK3R3BioGRID, IntAct26186194 28514442 details
TGFBR2DENND6ABioGRID, IntAct26186194 28514442 details
TGFBR2PLEKHH3BioGRID, IntAct26186194 28514442 details
TGFBR2LRP10BioGRID, IntAct26186194 28514442 details
TGFBR2PKN3BioGRID, IntAct26186194 28514442 details
TGFBR2PKN2BioGRID, IntAct26186194 28514442 details
TGFBR2ACVR2BBioGRID, IntAct26186194 28514442 details
TGFBR2PTPRSBioGRID, IntAct26186194 28514442 details
TGFBR2MFAP3BioGRID, IntAct26186194 28514442 details
TGFBR2PIK3CBBioGRID, IntAct26186194 28514442 details
TGFBR2BMPR1ABioGRID, IntAct26186194 28514442 details
TGFBR2JAK1BioGRID, IntAct26186194 28514442 details
TGFBR2FGFR1BioGRID, IntAct26186194 28514442 details
TGFBR2ERBB2BioGRID, IntAct26186194 28514442 details
TGFBR2SBF1BioGRID, IntAct26186194 28514442 details
TGFBR2ACVR2ABioGRID26186194 details
TGFBR2TYK2BioGRID26186194 details
TGFBR2LSRBioGRID26186194 details
TGFBR2RAB6ABioGRID26186194 details
TGFBR2WDR44BioGRID26186194 details
TGFBR2CD320BioGRID26186194 details
TGFBR2DIP2ABioGRID26186194 details
TGFBR2PTPRFBioGRID26186194 details
TGFBR2EHD4BioGRID26186194 details
TGFBR2ACVR1BBioGRID26186194 details
TGFBR2FAM171A2BioGRID26186194 details
TGFBR2CTDNEP1BioGRID26186194 details
TGFBR2U2SURPBioGRID28443643 details
TGFBR2PSMD11BioGRID28443643 details
TGFBR2ACSL4BioGRID28443643 details
TGFBR2ERAL1BioGRID28443643 details
TGFBR2RSL1D1BioGRID28443643 details
TGFBR2HK1BioGRID28443643 details
TGFBR2EEF1DBioGRID28443643 details
TGFBR2ATP6V1ABioGRID28443643 details
TGFBR2BAG6BioGRID28443643 details
TGFBR2PSMC1BioGRID28443643 details
TGFBR2EIF3ABioGRID28443643 details
TGFBR2COQ8BBioGRID28443643 details
TGFBR2CDC5LBioGRID28443643 details
TGFBR2GTPBP4BioGRID28443643 details
TGFBR2ABCB7BioGRID28443643 details
TGFBR2FADS2BioGRID28443643 details
TGFBR2PGK1BioGRID28443643 details
TGFBR2ALDOABioGRID28443643 details
TGFBR2PKMBioGRID28443643 details
TGFBR2PSMA3BioGRID28443643 details
TGFBR2PSMA4BioGRID28443643 details
TGFBR2SLC7A1BioGRID28443643 details
TGFBR2COPB2BioGRID28443643 details
TGFBR2STAT1BioGRID28443643 details
TGFBR2PSMC4BioGRID28443643 details
TGFBR2IDH2BioGRID28443643 details
TGFBR2PEX3BioGRID28443643 details
TGFBR2RPS3ABioGRID28443643 details
TGFBR2RPL8BioGRID28443643 details
TGFBR2ASPHBioGRID28443643 details
TGFBR2KRR1BioGRID28443643 details
TGFBR2SPTAN1BioGRID28443643 details
TGFBR2CKAP5BioGRID28443643 details
TGFBR2TRAM1BioGRID28443643 details
TGFBR2CYP51A1BioGRID28443643 details
TGFBR2MTHFD1LBioGRID28443643 details
TGFBR2EIF3MBioGRID28443643 details
TGFBR2ADCK1BioGRID28443643 details
TGFBR2ABHD12BioGRID28443643 details
TGFBR2KHSRPBioGRID28443643 details
TGFBR2CCDC47BioGRID28443643 details
TGFBR2DDX27BioGRID28443643 details
TGFBR2MTRBioGRID28443643 details
TGFBR2MAGT1BioGRID28443643 details
TGFBR2WDR6BioGRID28443643 details
TGFBR2AAASBioGRID28443643 details
TGFBR2DDX18BioGRID28443643 details
TGFBR2ATXN10BioGRID28443643 details
TGFBR2SEC63BioGRID28443643 details
TGFBR2PSMD13BioGRID28443643 details
TGFBR2RCE1BioGRID28443643 details
TGFBR2PLAABioGRID28443643 details
TGFBR2YTHDF2BioGRID28443643 details
TGFBR2SIN3AIntAct19088080 details
TGFBR2H4-16IntAct19088080 details
TGFBR2H4C15IntAct19088080 details
TGFBR2H4C9IntAct19088080 details
TGFBR2H4C1IntAct19088080 details
TGFBR2H4C4IntAct19088080 details
TGFBR2H4C6IntAct19088080 details
TGFBR2H4C12IntAct19088080 details
TGFBR2H4C11IntAct19088080 details
TGFBR2H4C3IntAct19088080 details
TGFBR2H4C8IntAct19088080 details
TGFBR2H4C2IntAct19088080 details
TGFBR2H4C5IntAct19088080 details
TGFBR2H4C13IntAct19088080 details
TGFBR2H4C14IntAct19088080 details
TGFBR2TRIM25BioGRID29117863 details
TGFBR2VIRMABioGRID29507755 details