Entity Details

Primary name WT1
Entity type gene
Source Source Link

Details

PrimaryID7490
RefseqGeneNG_009272
SymbolWT1
NameWT1 transcription factor
Chromosome11
Location11p13
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-25
ModificationDate2021-06-20

Ontological Relatives

UniProt IDsWT1_HUMAN

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001570 vasculogenesis
GO:0001657 ureteric bud development
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001822 kidney development
GO:0003156 regulation of animal organ formation
GO:0003700 DNA-binding transcription factor activity
GO:0003723 RNA binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007281 germ cell development
GO:0007356 thorax and anterior abdomen determination
GO:0007507 heart development
GO:0007530 sex determination
GO:0008270 zinc ion binding
GO:0008285 negative regulation of cell population proliferation
GO:0008380 RNA splicing
GO:0008406 gonad development
GO:0008584 male gonad development
GO:0009888 tissue development
GO:0010385 double-stranded methylated DNA binding
GO:0010628 positive regulation of gene expression
GO:0016607 nuclear speck
GO:0017148 negative regulation of translation
GO:0030308 negative regulation of cell growth
GO:0030325 adrenal gland development
GO:0030539 male genitalia development
GO:0030855 epithelial cell differentiation
GO:0032835 glomerulus development
GO:0032836 glomerular basement membrane development
GO:0035802 adrenal cortex formation
GO:0043010 camera-type eye development
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043565 sequence-specific DNA binding
GO:0044729 hemi-methylated DNA-binding
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0060231 mesenchymal to epithelial transition
GO:0060421 positive regulation of heart growth
GO:0060539 diaphragm development
GO:0060923 cardiac muscle cell fate commitment
GO:0061032 visceral serous pericardium development
GO:0070742 C2H2 zinc finger domain binding
GO:0071320 cellular response to cAMP
GO:0071371 cellular response to gonadotropin stimulus
GO:0072075 metanephric mesenchyme development
GO:0072112 glomerular visceral epithelial cell differentiation
GO:0072166 posterior mesonephric tubule development
GO:0072207 metanephric epithelium development
GO:0072284 metanephric S-shaped body morphogenesis
GO:0072302 negative regulation of metanephric glomerular mesangial cell proliferation
GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II
GO:1905643 positive regulation of DNA methylation
GO:2000020 positive regulation of male gonad development
GO:2000195 negative regulation of female gonad development
GO:2001076 positive regulation of metanephric ureteric bud development

Diseases

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Interactions

106 interactions

InteractorPartnerSourcesPublicationsLink
WT1DVL3BioGRID, IntAct, MINT19447967 21900206 27229929 details
WT1MDM2BioGRID, IntAct21988832 details
WT1NPM3BioGRID, MINT21900206 details
WT1TAOK1BioGRID, MINT21900206 details
WT1ZNF205BioGRID, MINT21900206 details
WT1CASZ1BioGRID, MINT25640309 details
WT1CCL5BioGRID, MINT25640309 details
WT1DIRAS3BioGRID, MINT25640309 details
WT1KLK7BioGRID, MINT25640309 details
WT1NAT2BioGRID, MINT25640309 details
WT1THRSPBioGRID, MINT25640309 details
WT1KRTAP10-8BioGRID, IntAct25416956 details
WT1KRT40BioGRID, IntAct25416956 31515488 details
WT1DVL2BioGRID, IntAct27107012 27229929 details
WT1CYSRT1BioGRID, IntAct32296183 details
WT1IPO8BioGRID, IntAct32296183 details
WT1OSBPL3BioGRID, IntAct32296183 details
WT1ZRANB1BioGRID, IntAct32296183 details
WT1BHLHE40BioGRID, IntAct32296183 details
WT1KRTAP10-7BioGRID, IntAct27229929 32296183 details
WT1PICK1BioGRID, IntAct32296183 details
WT1HMBOX1BioGRID, IntAct27229929 32296183 details
WT1KRTAP10-6BioGRID, IntAct32296183 details
WT1WTAPBioGRID, HPRD, IntAct11001926 26071132 32296183 details
WT1TRIM55BioGRID, IntAct31391242 details
WT1TET2IntAct25601757 details
WT1TP53BioGRID, HPRD, IntAct10744705 25601757 8389468 9556563 details
WT1CHATIntAct32814053 details
WT1FGFR3IntAct32814053 details
WT1HRASIntAct32814053 details
WT1DNAJB1IntAct32814053 details
WT1PECAM1IntAct32814053 details
WT1TGFBR2IntAct32814053 details
WT1SQSTM1IntAct32814053 details
WT1APPIntAct32814053 details
WT1UBE2IBioGRID, HPRD8798754 details
WT1PAWRBioGRID, HPRD8943350 details
WT1U2AF2BioGRID, HPRD9784496 details
WT1CIAO1BioGRID, HPRD9556563 details
WT1EGR1BioGRID19067769 details
WT1KRTAP10-3BioGRID25416956 27229929 details
WT1CCDC136BioGRID27229929 details
WT1CCDC33BioGRID27229929 details
WT1CEP70BioGRID27229929 details
WT1ETV7BioGRID27229929 details
WT1FAM9BBioGRID27229929 details
WT1FMR1NBBioGRID27229929 details
WT1GOLGA2BioGRID27229929 details
WT1IDI1BioGRID27229929 details
WT1KPNA4BioGRID27229929 details
WT1KPNA5BioGRID27229929 details
WT1KRTAP10-1BioGRID27229929 details
WT1KRTAP10-9BioGRID27229929 details
WT1LDOC1BioGRID27229929 details
WT1MAGEA8BioGRID27229929 details
WT1RNASEH2BBioGRID27229929 details
WT1SERF2BioGRID27229929 details
WT1THAP1BioGRID27229929 details
WT1MYCBioGRID28205554 details
WT1WT1BioGRID28205554 details
WT1GLIS2BioGRID28205554 details
WT1SOX4BioGRID28205554 details
WT1STK11BioGRID28205554 details
WT1TRIM63BioGRID31391242 details
WT1OGTBioGRID32994395 details
WT1WTIPHPRD14736876 details
WT1MEN1BioGRID21378168 details
WT1SUZ12BioGRID21378168 details
WT1EZH2BioGRID21378168 details
WT1DNMT1BioGRID21378168 details
WT1HSPA4BioGRID9553041 details
WT1PAX2HPRD14603255 details
WT1CREBBPHPRD11278547 details
WT1PRKACAHPRD9366517 details
WT1TP73HPRD10744705 details
WT1FHL2HPRD12151099 details
WT1TP63HPRD10744705 details
WT1AREGHPRD10490105 details
WT1NANOGBioGRID26687479 details
WT1NR2C2BioGRID30463901 details
WT1CCL1IntAct33179750 details
WT1CCL11IntAct33179750 details
WT1CCL14IntAct33179750 details
WT1CCL21IntAct33179750 details
WT1CCL22IntAct33179750 details
WT1CCL24IntAct33179750 details
WT1CCL26IntAct33179750 details
WT1CCL4L2IntAct33179750 details
WT1CCL4IntAct33179750 details
WT1CX3CL1IntAct33179750 details
WT1CSF2IntAct33179750 details
WT1CXCL5IntAct33179750 details
WT1CXCL3IntAct33179750 details
WT1IFNL1IntAct33179750 details
WT1IL17BIntAct33179750 details
WT1IL1RNIntAct33179750 details
WT1IL23AIntAct33179750 details
WT1IL25IntAct33179750 details
WT1IL27IntAct33179750 details
WT1IL31IntAct33179750 details
WT1IL32IntAct33179750 details
WT1OSMIntAct33179750 details
WT1TNFSF13IntAct33179750 details
WT1TNFSF12IntAct33179750 details
WT1TNFSF10IntAct33179750 details
WT1TNFSF8IntAct33179750 details