Entity Details

Primary name NB5R4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ7L1T6
EntryNameNB5R4_HUMAN
FullNameCytochrome b5 reductase 4
TaxID9606
Evidenceevidence at protein level
Length521
SequenceStatuscomplete
DateCreated2007-05-15
DateModified2021-06-02

Ontological Relatives

GenesCYB5R4

GO terms

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GOName
GO:0003032 detection of oxygen
GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0006091 generation of precursor metabolites and energy
GO:0006801 superoxide metabolic process
GO:0015701 bicarbonate transport
GO:0016174 NAD(P)H oxidase H2O2-forming activity
GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor
GO:0020037 heme binding
GO:0030073 insulin secretion
GO:0042593 glucose homeostasis
GO:0046677 response to antibiotic
GO:0046872 metal ion binding
GO:0048468 cell development
GO:0048471 perinuclear region of cytoplasm
GO:0072593 reactive oxygen species metabolic process

Subcellular Location

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Subcellular Location
Endoplasmic reticulum

Domains

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DomainNameCategoryType
IPR001199 Cytochrome b5-like heme/steroid binding domainDomainDomain
IPR001433 Oxidoreductase FAD/NAD(P)-bindingDomainDomain
IPR001834 NADH:cytochrome b5 reductase-likeFamilyFamily
IPR007052 CS domainDomainDomain
IPR008333 Flavoprotein pyridine nucleotide cytochrome reductase-like, FAD-binding domainDomainDomain
IPR008978 HSP20-like chaperoneFamilyHomologous superfamily
IPR017927 FAD-binding domain, ferredoxin reductase-typeDomainDomain
IPR017938 Riboflavin synthase-like beta-barrelFamilyHomologous superfamily
IPR018506 Cytochrome b5, heme-binding siteSiteBinding site
IPR036400 Cytochrome b5-like heme/steroid binding domain superfamilyFamilyHomologous superfamily
IPR037908 Cytochrome b5 reductase 4, p23 domainDomainDomain
IPR039261 Ferredoxin-NADP reductase (FNR), nucleotide-binding domainFamilyHomologous superfamily

Diseases

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Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
NB5R4_HUMANPAXI1_HUMANBioGRID22990118 details