Entity Details

Primary name DOCK3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ8IZD9
EntryNameDOCK3_HUMAN
FullNameDedicator of cytokinesis protein 3
TaxID9606
Evidenceevidence at protein level
Length2030
SequenceStatuscomplete
DateCreated2003-07-03
DateModified2021-06-02

Ontological Relatives

GenesDOCK3

GO terms

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GOName
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005829 cytosol
GO:0007264 small GTPase mediated signal transduction
GO:0017124 SH3 domain binding
GO:1903997 positive regulation of non-membrane spanning protein tyrosine kinase activity

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR001452 SH3 domainDomainDomain
IPR016024 Armadillo-type foldFamilyHomologous superfamily
IPR026791 Dedicator of cytokinesisFamilyFamily
IPR026800 Dedicator of cytokinesis 3FamilyFamily
IPR027007 C2 DOCK-type domainDomainDomain
IPR027357 DOCKER domainDomainDomain
IPR032376 Dedicator of cytokinesis, N-terminal domainDomainDomain
IPR035767 Dedicator of cytokinesis 3, SH3 domainDomainDomain
IPR035892 C2 domain superfamilyFamilyHomologous superfamily
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily
IPR037811 Dedicator of cytokinesis B, C2 domainDomainDomain
IPR042455 Dedicator of cytokinesis, N-terminal, subdomain 1FamilyHomologous superfamily
IPR043161 Dedicator of cytokinesis, C-terminal, lobe AFamilyHomologous superfamily
IPR043162 Dedicator of cytokinesis, C-terminal, lobe CFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
618292 OMIMNeurodevelopmental disorder with impaired intellectual development, hypotonia, and ataxia (NEDIDHA)An autosomal recessive disease characterized by global developmental delay, hypotonia, ataxic gait, hyporeflexia, poor or absent speech, and variable and mild dysmorphic features. The disease is caused by variants affecting the gene represented in this entry.