Entity Details

Primary name GLIS3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ8NEA6
EntryNameGLIS3_HUMAN
FullNameZinc finger protein GLIS3
TaxID9606
Evidenceevidence at protein level
Length775
SequenceStatuscomplete
DateCreated2004-04-13
DateModified2021-06-02

Ontological Relatives

GenesGLIS3

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0005634 nucleus
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006366 transcription by RNA polymerase II
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046872 metal ion binding

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR013087 Zinc finger C2H2-typeDomainDomain
IPR030405 Zinc finger protein GLIS3FamilyFamily
IPR036236 Zinc finger C2H2 superfamilyFamilyHomologous superfamily
IPR043359 C2H2-type zinc-finger protein GLI-likeFamilyFamily

Diseases

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Disease IDSourceNameDescription
610199 OMIMDiabetes mellitus, neonatal, with congenital hypothyroidism (NDH)A syndrome of neonatal diabetes syndrome associated with congenital hypothyroidism, congenital glaucoma, hepatic fibrosis and polycystic kidneys. The disease is caused by variants affecting the gene represented in this entry.