Entity Details

Primary name SFRP3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ92765
EntryNameSFRP3_HUMAN
FullNameSecreted frizzled-related protein 3
TaxID9606
Evidenceevidence at protein level
Length325
SequenceStatuscomplete
DateCreated2001-06-01
DateModified2021-06-02

Ontological Relatives

GenesFRZB

GO terms

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GOName
GO:0001501 skeletal system development
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0008285 negative regulation of cell population proliferation
GO:0010721 negative regulation of cell development
GO:0014033 neural crest cell differentiation
GO:0016020 membrane
GO:0017147 Wnt-protein binding
GO:0030178 negative regulation of Wnt signaling pathway
GO:0030308 negative regulation of cell growth
GO:0043065 positive regulation of apoptotic process
GO:0045600 positive regulation of fat cell differentiation
GO:0060029 convergent extension involved in organogenesis
GO:0060070 canonical Wnt signaling pathway
GO:0061037 negative regulation of cartilage development
GO:0061053 somite development
GO:0070367 negative regulation of hepatocyte differentiation
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090103 cochlea morphogenesis

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR001134 Netrin domainDomainDomain
IPR008993 Tissue inhibitor of metalloproteinases-like, OB-foldFamilyHomologous superfamily
IPR015526 Frizzled/secreted frizzled-related proteinFamilyFamily
IPR018933 Netrin module, non-TIMP typeDomainDomain
IPR020067 Frizzled domainDomainDomain
IPR026556 Secreted frizzled-related protein 3FamilyFamily
IPR035813 Secreted frizzled-related protein 3, NTR domainDomainDomain
IPR036790 Frizzled cysteine-rich domain superfamilyFamilyHomologous superfamily
IPR041759 SFRP3, cysteine-rich domainDomainDomain

Diseases

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Disease IDSourceNameDescription
165720 OMIMOsteoarthritis 1 (OS1)A degenerative disease of the joints characterized by degradation of the hyaline articular cartilage and remodeling of the subchondral bone with sclerosis. Clinical symptoms include pain and joint stiffness often leading to significant disability and joint replacement. Disease susceptibility is associated with variants affecting the gene represented in this entry.