Entity Details

Primary name COQ8B_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ96D53
EntryNameCOQ8B_HUMAN
FullNameAtypical kinase COQ8B, mitochondrial
TaxID9606
Evidenceevidence at protein level
Length544
SequenceStatuscomplete
DateCreated2007-01-09
DateModified2021-06-02

Ontological Relatives

GenesCOQ8B

GO terms

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GOName
GO:0005524 ATP binding
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006468 protein phosphorylation
GO:0006744 ubiquinone biosynthetic process
GO:0008289 lipid binding
GO:0016021 integral component of membrane
GO:0016301 kinase activity
GO:0016887 ATP hydrolysis activity
GO:0021692 cerebellar Purkinje cell layer morphogenesis
GO:0031314 extrinsic component of mitochondrial inner membrane

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Mitochondrion membrane

Domains

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DomainNameCategoryType
IPR004147 UbiB domainDomainDomain
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR034638 Atypical kinase COQ8BFamilyFamily
IPR034646 UbiB domain, ADCK3-likeDomainDomain

Diseases

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Disease IDSourceNameDescription
615573 OMIMNephrotic syndrome 9 (NPHS9)A form of nephrotic syndrome, a renal disease clinically characterized by progressive renal failure, severe proteinuria, hypoalbuminemia, hyperlipidemia and edema. Kidney biopsies show focal segmental glomerulosclerosis. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
COQ8B_HUMANOGT1_HUMANBioGRID32994395 details