Entity Details

Primary name SET1A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO15047
EntryNameSET1A_HUMAN
FullNameHistone-lysine N-methyltransferase SETD1A
TaxID9606
Evidenceevidence at protein level
Length1707
SequenceStatuscomplete
DateCreated2005-06-21
DateModified2021-06-02

Ontological Relatives

GenesSETD1A

GO terms

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GOName
GO:0000785 chromatin
GO:0003723 RNA binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0007420 brain development
GO:0008013 beta-catenin binding
GO:0008134 transcription factor binding
GO:0016607 nuclear speck
GO:0035097 histone methyltransferase complex
GO:0042800 histone methyltransferase activity (H3-K4 specific)
GO:0044648 histone H3-K4 dimethylation
GO:0045652 regulation of megakaryocyte differentiation
GO:0048188 Set1C/COMPASS complex
GO:0080182 histone H3-K4 trimethylation
GO:0097692 histone H3-K4 monomethylation
GO:1902036 regulation of hematopoietic stem cell differentiation
GO:1902275 regulation of chromatin organization

Subcellular Location

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Subcellular Location
Chromosome
Nucleus speckle

Domains

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DomainNameCategoryType
IPR000504 RNA recognition motif domainDomainDomain
IPR001214 SET domainDomainDomain
IPR003616 Post-SET domainDomainDomain
IPR012677 Nucleotide-binding alpha-beta plait domain superfamilyFamilyHomologous superfamily
IPR024657 COMPASS complex Set1 subunit, N-SET domainDomainDomain
IPR034467 Set1A, RNA recognition motifDomainDomain
IPR035979 RNA-binding domain superfamilyFamilyHomologous superfamily
IPR037841 Histone-lysine N-methyltransferase SETD1AFamilyFamily
IPR044570 Histone-lysine N-methyltransferase Set1-likeFamilyFamily

Diseases

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Interactions

22 interactions

InteractorPartnerSourcesPublicationsLink
SET1A_HUMANLBP_HUMANBioGRID, IntAct21988832 details
SET1A_HUMANWDR5_HUMANBioGRID, IntAct, MINT, UniProt15960975 16253997 17355966 20305087 22266653 22665483 23453808 23870121 24981860 26186194 27563068 27705803 28514442 29474905 31076518 details
SET1A_HUMANDPY30_HUMANBioGRID, IntAct, UniProt17500065 23453808 23870121 24981860 31076518 details
SET1A_HUMANWDR82_HUMANBioGRID, IntAct, MINT17355966 17998332 20516061 23870121 24981860 27563068 29474905 31076518 details
SET1A_HUMANASH2L_HUMANBioGRID, DIP, IntAct, MINT16253997 17998332 20305087 21653943 22939629 23453808 23870121 24981860 26886794 27563068 29474905 31076518 34079125 details
SET1A_HUMANRBBP5_HUMANBioGRID, IntAct16253997 17355966 17998332 20305087 20516061 21653943 22147691 22939629 23453808 23870121 24981860 27563068 29474905 29785026 31076518 details
SET1A_HUMANCXXC1_HUMANBioGRID, IntAct16253997 17355966 17998332 18082152 18680430 19410543 19433449 19951360 23453808 23870121 24981860 26496610 27563068 28514442 29474905 31076518 details
SET1A_HUMANP53_HUMANBioGRID, IntAct23870121 29474905 31076518 details
SET1A_HUMANEP300_HUMANBioGRID, IntAct23870121 details
SET1A_HUMANCBP_HUMANBioGRID16061203 details
SET1A_HUMANH32_HUMANBioGRID22266653 details
SET1A_HUMANH31_HUMANBioGRID19410543 23453808 23870121 details
SET1A_HUMANHCFC1_HUMANBioGRID, IntAct12670868 17998332 24981860 27563068 31076518 details
SET1A_HUMANMYB_HUMANIntAct20195357 details
SET1A_HUMANRPB1_HUMANBioGRID17998332 details
SET1A_HUMANUSF1_HUMANBioGRID17846119 21653943 details
SET1A_HUMANSMCA1_HUMANBioGRID21653943 details
SET1A_HUMANUVSSA_HUMANBioGRID22902626 details
SET1A_HUMANSET1B_HUMANBioGRID17355966 24981860 details
SET1A_HUMANZN207_HUMANBioGRID26472760 details
SET1A_HUMANCCNK_HUMANBioGRID29474905 details
SET1A_HUMANRAD18_HUMANBioGRID31076518 details