| Domain | Name | Category | Type |
| IPR010014 | Diphthamide synthesis DHP2 | Family | Family |
| IPR016435 | Diphthamide synthesis DPH1/DPH2 | Family | Family |
| IPR042263 | Diphthamide synthesis DPH1/DPH2, domain 1 | Family | Homologous superfamily |
| IPR042264 | Diphthamide synthesis DPH1/DPH2, domain 2 | Family | Homologous superfamily |
| IPR042265 | Diphthamide synthesis DPH1/DPH2, domain 3 | Family | Homologous superfamily |