Entity Details

Primary name INP5K_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9BT40
EntryNameINP5K_HUMAN
FullNameInositol polyphosphate 5-phosphatase K
TaxID9606
Evidenceevidence at protein level
Length448
SequenceStatuscomplete
DateCreated2003-09-26
DateModified2021-06-02

Ontological Relatives

GenesINPP5K

GO terms

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GOName
GO:0001701 in utero embryonic development
GO:0001726 ruffle
GO:0001933 negative regulation of protein phosphorylation
GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
GO:0004445 inositol-polyphosphate 5-phosphatase activity
GO:0005000 vasopressin receptor activity
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005802 trans-Golgi network
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005979 regulation of glycogen biosynthetic process
GO:0006469 negative regulation of protein kinase activity
GO:0006661 phosphatidylinositol biosynthetic process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0010801 negative regulation of peptidyl-threonine phosphorylation
GO:0010829 negative regulation of glucose transmembrane transport
GO:0016020 membrane
GO:0016311 dephosphorylation
GO:0016312 inositol bisphosphate phosphatase activity
GO:0030036 actin cytoskeleton organization
GO:0032587 ruffle membrane
GO:0032869 cellular response to insulin stimulus
GO:0032870 cellular response to hormone stimulus
GO:0033137 negative regulation of peptidyl-serine phosphorylation
GO:0034485 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
GO:0034594 phosphatidylinositol trisphosphate phosphatase activity
GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity
GO:0035305 negative regulation of dephosphorylation
GO:0035810 positive regulation of urine volume
GO:0042577 lipid phosphatase activity
GO:0042593 glucose homeostasis
GO:0043005 neuron projection
GO:0043407 negative regulation of MAP kinase activity
GO:0043922 negative regulation by host of viral transcription
GO:0045719 negative regulation of glycogen biosynthetic process
GO:0045869 negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046030 inositol trisphosphate phosphatase activity
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0046855 inositol phosphate dephosphorylation
GO:0046856 phosphatidylinositol dephosphorylation
GO:0048471 perinuclear region of cytoplasm
GO:0051497 negative regulation of stress fiber assembly
GO:0051898 negative regulation of protein kinase B signaling
GO:0051926 negative regulation of calcium ion transport
GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity
GO:0052659 inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity
GO:0071320 cellular response to cAMP
GO:0071356 cellular response to tumor necrosis factor
GO:0071364 cellular response to epidermal growth factor stimulus
GO:0072659 protein localization to plasma membrane
GO:0090315 negative regulation of protein targeting to membrane
GO:0097178 ruffle assembly
GO:2000466 negative regulation of glycogen (starch) synthase activity
GO:2001153 positive regulation of renal water transport

Subcellular Location

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Subcellular Location
Cytoplasm
Endoplasmic reticulum

Domains

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DomainNameCategoryType
IPR000300 Inositol polyphosphate-related phosphataseDomainDomain
IPR005135 Endonuclease/exonuclease/phosphataseDomainDomain
IPR036691 Endonuclease/exonuclease/phosphatase superfamilyFamilyHomologous superfamily
IPR041611 SKICH domainDomainDomain

Diseases

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Disease IDSourceNameDescription
617404 OMIMMuscular dystrophy, congenital, with cataracts and intellectual disability (MDCCAID)An autosomal recessive form of muscular dystrophy with onset in early childhood and characterized by progressive muscle weakness. Almost all patients also have early-onset cataracts and intellectual disability of varying severity. Some patients have seizures. The disease is caused by variants affecting the gene represented in this entry.

Interactions

29 interactions

InteractorPartnerSourcesPublicationsLink
INP5K_HUMANAR6P1_HUMANBioGRID, HPRD, IntAct16189514 29892012 32296183 details
INP5K_HUMANLNX1_HUMANIntAct16002321 details
INP5K_HUMANBDNF_HUMANBioGRID, IntAct21988832 details
INP5K_HUMANTANK_HUMANBioGRID, IntAct21988832 details
INP5K_HUMANCPTP_HUMANBioGRID, IntAct21988832 details
INP5K_HUMANANXA7_HUMANBioGRID, MINT21900206 details
INP5K_HUMANCDN1A_HUMANBioGRID, MINT21900206 details
INP5K_HUMANHMOX2_HUMANBioGRID, MINT21900206 details
INP5K_HUMANPFD1_HUMANBioGRID, MINT21900206 details
INP5K_HUMANSMN_HUMANBioGRID, MINT21900206 details
INP5K_HUMANKITH_HUMANBioGRID, MINT21900206 details
INP5K_HUMANTTHY_HUMANBioGRID, MINT21900206 details
INP5K_HUMANHSPB1_HUMANBioGRID, IntAct25277244 details
INP5K_HUMANMD2BP_HUMANBioGRID, IntAct25416956 28514442 29892012 32296183 details
INP5K_HUMANK1H1_HUMANBioGRID, IntAct25416956 32296183 details
INP5K_HUMANFATE1_HUMANBioGRID, IntAct25416956 29892012 32296183 details
INP5K_HUMANFADS6_HUMANBioGRID, IntAct32296183 details
INP5K_HUMANTR10D_HUMANBioGRID, IntAct32296183 details
INP5K_HUMANATP5J_HUMANBioGRID, IntAct32296183 details
INP5K_HUMANGOT1B_HUMANBioGRID, IntAct32296183 details
INP5K_HUMANSFT2B_HUMANBioGRID, IntAct32296183 details
INP5K_HUMANKLK6_HUMANIntAct32814053 details
INP5K_HUMANNCOR2_HUMANBioGRID11509665 details
INP5K_HUMANFBX7_HUMANBioGRID27503909 details
INP5K_HUMANPBX3_HUMANBioGRID32296183 details
INP5K_HUMANEPIPL_HUMANIntAct17353931 details
INP5K_HUMANPDXD1_HUMANIntAct17353931 details
INP5K_HUMANDCD_HUMANIntAct17353931 details
INP5K_HUMANPYGM_HUMANIntAct17353931 details