Entity Details

Primary name PHF1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO43189
EntryNamePHF1_HUMAN
FullNamePHD finger protein 1
TaxID9606
Evidenceevidence at protein level
Length567
SequenceStatuscomplete
DateCreated2000-12-01
DateModified2021-06-02

Ontological Relatives

GenesPHF1

GO terms

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GOName
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005815 microtubule organizing center
GO:0006325 chromatin organization
GO:0006355 regulation of transcription, DNA-templated
GO:0006974 cellular response to DNA damage stimulus
GO:0035064 methylated histone binding
GO:0035861 site of double-strand break
GO:0042802 identical protein binding
GO:0045814 negative regulation of gene expression, epigenetic
GO:0046872 metal ion binding
GO:0061086 negative regulation of histone H3-K27 methylation
GO:0061087 positive regulation of histone H3-K27 methylation
GO:1990226 histone methyltransferase binding

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001965 Zinc finger, PHD-typeDomainDomain
IPR002999 Tudor domainDomainDomain
IPR011011 Zinc finger, FYVE/PHD-typeFamilyHomologous superfamily
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR019786 Zinc finger, PHD-type, conserved siteSiteConserved site
IPR019787 Zinc finger, PHD-fingerDomainDomain
IPR025894 Polycomb-like MTF2 factor 2, C-terminal domainDomainDomain
IPR031202 PHD finger protein 1FamilyFamily
IPR040477 Lysine-specific demethylase 4, Tudor domainDomainDomain

Diseases

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Interactions

100 interactions

InteractorPartnerSourcesPublicationsLink
PHF1_HUMANEZH2_HUMANBioGRID, DIP, HPRD, IntAct, MINT11571280 18285464 18385154 23142980 23273982 24457600 24981860 26496610 27634302 27705803 28068325 29846670 details
PHF1_HUMANRBPMS_HUMANBioGRID, HPRD, IntAct16189514 25416956 32296183 details
PHF1_HUMANTHAP1_HUMANBioGRID, HPRD, IntAct16189514 32296183 details
PHF1_HUMANTFCP2_HUMANBioGRID, IntAct, MINT21516116 25416956 details
PHF1_HUMANDYSF_HUMANBioGRID, IntAct23414517 details
PHF1_HUMANDDB1_HUMANBioGRID, IntAct23238014 29846670 details
PHF1_HUMANTRI23_HUMANBioGRID, IntAct25416956 31515488 details
PHF1_HUMANVAC14_HUMANBioGRID, IntAct25416956 details
PHF1_HUMANCACO2_HUMANBioGRID, IntAct25416956 details
PHF1_HUMANNAB2_HUMANBioGRID, IntAct25416956 31515488 32296183 details
PHF1_HUMANBIRC7_HUMANBioGRID, IntAct25416956 31515488 details
PHF1_HUMANDHB14_HUMANBioGRID, IntAct25416956 31515488 32296183 details
PHF1_HUMANAT7L1_HUMANBioGRID, IntAct25416956 details
PHF1_HUMANPDLI7_HUMANBioGRID, IntAct25416956 31515488 details
PHF1_HUMANMDFI_HUMANBioGRID, IntAct32296183 details
PHF1_HUMANDISC1_HUMANBioGRID, IntAct32296183 details
PHF1_HUMANBOLL_HUMANBioGRID, IntAct32296183 details
PHF1_HUMANABI2_HUMANBioGRID, IntAct32296183 details
PHF1_HUMANARRD3_HUMANBioGRID, IntAct32296183 details
PHF1_HUMANK1C40_HUMANBioGRID, IntAct32296183 details
PHF1_HUMANPR20D_HUMANBioGRID, IntAct32296183 details
PHF1_HUMANUBP54_HUMANBioGRID, IntAct32296183 details
PHF1_HUMANRB8NL_HUMANBioGRID, IntAct32296183 details
PHF1_HUMANBHLH9_HUMANBioGRID, IntAct32296183 details
PHF1_HUMANTFP11_HUMANBioGRID, IntAct32296183 details
PHF1_HUMANLZTS2_HUMANBioGRID, IntAct32296183 details
PHF1_HUMANPATZ1_HUMANBioGRID, IntAct32296183 details
PHF1_HUMANPFD5_HUMANBioGRID, IntAct32296183 details
PHF1_HUMANINCA1_HUMANBioGRID, IntAct32296183 details
PHF1_HUMANFHL2_HUMANBioGRID, IntAct32296183 details
PHF1_HUMANZIM2_HUMANBioGRID, IntAct32296183 details
PHF1_HUMANAVPI1_HUMANBioGRID, IntAct32296183 details
PHF1_HUMANDPF1_HUMANBioGRID, IntAct32296183 details
PHF1_HUMANIKBP1_HUMANBioGRID, IntAct32296183 details
PHF1_HUMANCK049_HUMANBioGRID, IntAct32296183 details
PHF1_HUMANZN500_HUMANBioGRID, IntAct32296183 details
PHF1_HUMANFOSB_HUMANBioGRID, IntAct32296183 details
PHF1_HUMANZBT10_HUMANBioGRID, IntAct32296183 details
PHF1_HUMANBHE40_HUMANBioGRID, IntAct32296183 details
PHF1_HUMANZRAN1_HUMANBioGRID, IntAct32296183 details
PHF1_HUMANMAGD1_HUMANBioGRID, IntAct32296183 details
PHF1_HUMANTNS2_HUMANBioGRID, IntAct32296183 details
PHF1_HUMANVINEX_HUMANBioGRID, IntAct32296183 details
PHF1_HUMANGG6L9_HUMANBioGRID, IntAct32296183 details
PHF1_HUMANZN526_HUMANBioGRID, IntAct32296183 details
PHF1_HUMANLBX1_HUMANBioGRID, IntAct32296183 details
PHF1_HUMANEFHC2_HUMANBioGRID, IntAct32296183 details
PHF1_HUMANTLE5_HUMANBioGRID, IntAct32296183 details
PHF1_HUMANGPKOW_HUMANBioGRID, IntAct32296183 details
PHF1_HUMANTOX2_HUMANBioGRID, IntAct32296183 details
PHF1_HUMANARI5A_HUMANBioGRID, IntAct32296183 details
PHF1_HUMANZBT16_HUMANBioGRID, IntAct32296183 details
PHF1_HUMANSMG9_HUMANBioGRID, IntAct32296183 details
PHF1_HUMANSPAG8_HUMANBioGRID, IntAct32296183 details
PHF1_HUMANMORN3_HUMANBioGRID, IntAct32296183 details
PHF1_HUMANZNF71_HUMANBioGRID, IntAct32296183 details
PHF1_HUMANK0408_HUMANBioGRID, IntAct32296183 details
PHF1_HUMANZN688_HUMANBioGRID, IntAct32296183 details
PHF1_HUMANH31_HUMANBioGRID21167174 29846670 details
PHF1_HUMANHIC1_HUMANBioGRID22315224 details
PHF1_HUMANNEK6_HUMANBioGRID20873783 details
PHF1_HUMANH31T_HUMANBioGRID23273982 details
PHF1_HUMANH4_HUMANBioGRID29846670 details
PHF1_HUMANANM5_HUMANBioGRID29846670 details
PHF1_HUMANPIBF1_HUMANBioGRID32296183 details
PHF1_HUMANMEOX2_HUMANBioGRID32296183 details
PHF1_HUMANZSC32_HUMANBioGRID32296183 details
PHF1_HUMANASPP2_HUMANBioGRID32296183 details
PHF1_HUMANPR20E_HUMANBioGRID32296183 details
PHF1_HUMANPR20C_HUMANBioGRID32296183 details
PHF1_HUMANPR20B_HUMANBioGRID32296183 details
PHF1_HUMANPR20A_HUMANBioGRID32296183 details
PHF1_HUMANHOMEZ_HUMANBioGRID32296183 details
PHF1_HUMANCUL4B_HUMANBioGRID, IntAct23238014 29846670 details
PHF1_HUMANEED_HUMANBioGRID, IntAct, MINT18285464 23273982 24981860 26496610 27705803 29846670 details
PHF1_HUMANEZH1_HUMANBioGRID, IntAct, MINT23273982 24981860 27705803 details
PHF1_HUMANSUZ12_HUMANBioGRID, IntAct, MINT18285464 18385154 23273982 24457600 24981860 27634302 27705803 28514442 29846670 details
PHF1_HUMANRBBP4_HUMANBioGRID, IntAct, MINT23273982 24981860 27705803 29846670 details
PHF1_HUMANP53_HUMANBioGRID, IntAct18385154 23150668 27705803 details
PHF1_HUMANRBBP7_HUMANBioGRID, IntAct, MINT18285464 18385154 24981860 27705803 29846670 details
PHF1_HUMANXRCC5_HUMANBioGRID18385154 details
PHF1_HUMANXRCC6_HUMANBioGRID18385154 details
PHF1_HUMANSMC1A_HUMANBioGRID18385154 details
PHF1_HUMANNCTR1_HUMANBioGRID18385154 details
PHF1_HUMANRAD50_HUMANBioGRID18385154 details
PHF1_HUMANDHX9_HUMANBioGRID18385154 details
PHF1_HUMANHDAC1_HUMANBioGRID23273982 29846670 details
PHF1_HUMANRPB7_HUMANBioGRID23273982 details
PHF1_HUMANMEP50_HUMANBioGRID29846670 details
PHF1_HUMANNCOA3_HUMANBioGRID29846670 details
PHF1_HUMANHDAC2_HUMANBioGRID24981860 29846670 details
PHF1_HUMANMTA1_HUMANBioGRID24981860 29846670 details
PHF1_HUMANMTA3_HUMANBioGRID24981860 29846670 details
PHF1_HUMANSIN3A_HUMANBioGRID24981860 29846670 details
PHF1_HUMANRBX1_HUMANBioGRID29846670 details
PHF1_HUMANARI4B_HUMANBioGRID24981860 29846670 details
PHF1_HUMANSAP30_HUMANBioGRID24981860 29846670 details
PHF1_HUMANSRC_HUMANBioGRID29846670 details
PHF1_HUMANGRIP1_HUMANBioGRID29846670 details
PHF1_HUMANKDM1A_HUMANBioGRID29846670 details