Entity Details

Primary name ING3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9NXR8
EntryNameING3_HUMAN
FullNameInhibitor of growth protein 3
TaxID9606
Evidenceevidence at protein level
Length418
SequenceStatuscomplete
DateCreated2005-02-15
DateModified2021-06-02

Ontological Relatives

GenesING3

GO terms

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GOName
GO:0000812 Swr1 complex
GO:0005654 nucleoplasm
GO:0032777 Piccolo NuA4 histone acetyltransferase complex
GO:0035064 methylated histone binding
GO:0035267 NuA4 histone acetyltransferase complex
GO:0040008 regulation of growth
GO:0043065 positive regulation of apoptotic process
GO:0043967 histone H4 acetylation
GO:0043968 histone H2A acetylation
GO:0046872 metal ion binding

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001965 Zinc finger, PHD-typeDomainDomain
IPR011011 Zinc finger, FYVE/PHD-typeFamilyHomologous superfamily
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR019786 Zinc finger, PHD-type, conserved siteSiteConserved site
IPR019787 Zinc finger, PHD-fingerDomainDomain
IPR024610 Inhibitor of growth protein, N-terminal histone-bindingDomainDomain
IPR028651 ING familyFamilyFamily
IPR038004 Inhibitor of growth protein 3FamilyFamily
IPR042020 ING3, PHD domainDomainDomain

Diseases

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Disease IDSourceNameDescription
275355 OMIMSquamous cell carcinoma of the head and neck (HNSCC)A non-melanoma skin cancer affecting the head and neck. The hallmark of cutaneous SCC is malignant transformation of normal epidermal keratinocytes. The disease may be caused by variants affecting the gene represented in this entry.

Interactions

26 interactions

InteractorPartnerSourcesPublicationsLink
ING3_HUMANNR1H2_HUMANBioGRID, HPRD15604093 details
ING3_HUMANNR1H3_HUMANBioGRID, HPRD15604093 details
ING3_HUMANA4_HUMANBioGRID21832049 details
ING3_HUMANFBX25_HUMANBioGRID23940030 details
ING3_HUMANTEX11_HUMANBioGRID25416956 32296183 details
ING3_HUMANTRI54_HUMANBioGRID25416956 details
ING3_HUMANUSBP1_HUMANBioGRID25416956 details
ING3_HUMANBEX5_HUMANBioGRID32296183 details
ING3_HUMANSIVA_HUMANBioGRID32296183 details
ING3_HUMANRUVB2_HUMANBioGRID, IntAct16230350 16387653 26496610 28514442 details
ING3_HUMANACL6A_HUMANBioGRID, IntAct14966270 15647280 16387653 details
ING3_HUMANKAT5_HUMANBioGRID, IntAct14966270 16387653 20946988 26186194 26496610 27153538 28514442 details
ING3_HUMANDMAP1_HUMANBioGRID, IntAct14966270 16387653 20946988 26496610 details
ING3_HUMANYETS4_HUMANBioGRID, IntAct16387653 26186194 26496610 28514442 details
ING3_HUMANKAT7_HUMANBioGRID, IntAct26496610 27270040 details
ING3_HUMANRUVB1_HUMANBioGRID, IntAct14966270 16387653 26496610 28514442 details
ING3_HUMANBRD8_HUMANBioGRID, IntAct16387653 26496610 31753913 details
ING3_HUMANEPC1_HUMANBioGRID, IntAct14966270 16387653 26496610 27153538 details
ING3_HUMANEPC2_HUMANBioGRID, IntAct16387653 26496610 details
ING3_HUMANEAF6_HUMANBioGRID, IntAct16387653 26496610 28514442 details
ING3_HUMANMO4L1_HUMANBioGRID, IntAct14966270 16387653 26186194 28514442 details
ING3_HUMANCDC5L_HUMANIntAct31413325 details
ING3_HUMANTRRAP_HUMANBioGRID14966270 16387653 26496610 details
ING3_HUMANRBX1_HUMANBioGRID19935701 details
ING3_HUMANCUL1_HUMANBioGRID19935701 details
ING3_HUMANSKP2_HUMANBioGRID19935701 details