Entity Details

Primary name KLHL3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9UH77
EntryNameKLHL3_HUMAN
FullNameKelch-like protein 3
TaxID9606
Evidenceevidence at protein level
Length587
SequenceStatuscomplete
DateCreated2001-04-27
DateModified2021-06-02

Ontological Relatives

GenesKLHL3

GO terms

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GOName
GO:0003779 actin binding
GO:0005198 structural molecule activity
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0016567 protein ubiquitination
GO:0031463 Cul3-RING ubiquitin ligase complex
GO:0043687 post-translational protein modification
GO:0050801 ion homeostasis
GO:0061912 selective autophagy
GO:0070294 renal sodium ion absorption
GO:0070936 protein K48-linked ubiquitination
GO:0072156 distal tubule morphogenesis
GO:0097602 cullin family protein binding

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000210 BTB/POZ domainDomainDomain
IPR006652 Kelch repeat type 1RepeatRepeat
IPR011333 SKP1/BTB/POZ domain superfamilyFamilyHomologous superfamily
IPR011705 BTB/Kelch-associatedDomainDomain
IPR015915 Kelch-type beta propellerFamilyHomologous superfamily
IPR017096 BTB-kelch proteinFamilyFamily
IPR030578 Kelch-like protein 3FamilyFamily

Diseases

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Disease IDSourceNameDescription
614495 OMIMPseudohypoaldosteronism 2D (PHA2D)A disorder characterized by severe hypertension, hyperkalemia, hyperchloremia, hyperchloremic metabolic acidosis, and correction of physiologic abnormalities by thiazide diuretics. PHA2D inheritance is autosomal dominant or recessive. The disease is caused by variants affecting the gene represented in this entry.

Interactions

32 interactions

InteractorPartnerSourcesPublicationsLink
KLHL3_HUMANCUL3_HUMANBioGRID, IntAct, MINT23387299 23453970 23573258 23576762 23665031 23838290 25250572 25416956 25502805 26100637 26286618 30819806 31515488 32296183 details
KLHL3_HUMANWNK4_HUMANBioGRID, MINT23453970 23576762 23665031 23838290 23962426 24641320 25313067 26286618 26349538 26435498 details
KLHL3_HUMANKLH12_HUMANBioGRID, IntAct25416956 32296183 details
KLHL3_HUMANKLHL2_HUMANBioGRID, IntAct28514442 32296183 details
KLHL3_HUMANTNPO2_HUMANBioGRID, IntAct32296183 details
KLHL3_HUMANKEAP1_HUMANBioGRID, IntAct25416956 32296183 details
KLHL3_HUMANCASP6_HUMANIntAct32814053 details
KLHL3_HUMANFGFR3_HUMANIntAct32814053 details
KLHL3_HUMANGELS_HUMANIntAct32814053 details
KLHL3_HUMANRASH_HUMANIntAct32814053 details
KLHL3_HUMANLAMP2_HUMANIntAct32814053 details
KLHL3_HUMANKLF11_HUMANIntAct32814053 details
KLHL3_HUMANDNJB6_HUMANIntAct32814053 details
KLHL3_HUMANWNK1_HUMANBioGRID23387299 23576762 23838290 26286618 29904119 details
KLHL3_HUMANWNK3_HUMANBioGRID23387299 23838290 24641320 details
KLHL3_HUMANKLHL3_HUMANBioGRID23387299 25416956 details
KLHL3_HUMANMO4L2_HUMANBioGRID25416956 details
KLHL3_HUMANCF206_HUMANBioGRID25416956 details
KLHL3_HUMANKAPCA_HUMANBioGRID26435498 details
KLHL3_HUMANAKT1_HUMANBioGRID26435498 details
KLHL3_HUMANPP2BA_HUMANBioGRID30718414 details
KLHL3_HUMANS12A3_HUMANBioGRID22406640 details
KLHL3_HUMANWNK2_HUMANBioGRID23387299 23838290 details
KLHL3_HUMANRBX1_HUMANBioGRID23387299 details
KLHL3_HUMANCLD8_HUMANBioGRID25831548 details
KLHL3_HUMANSQSTM_HUMANBioGRID26349538 details
KLHL3_HUMANSOX9_HUMANBioGRID33173725 details
KLHL3_HUMANOPRD_HUMANHPRD11259487 details
KLHL3_HUMANSYT2_HUMANHPRD10734137 details
KLHL3_HUMANHNRPQ_HUMANHPRD10734137 details
KLHL3_HUMANGNAI1_HUMANHPRD11259487 details
KLHL3_HUMANGNAO_HUMANHPRD11259487 details