Entity Details

Primary name ZN148_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9UQR1
EntryNameZN148_HUMAN
FullNameZinc finger protein 148
TaxID9606
Evidenceevidence at protein level
Length794
SequenceStatuscomplete
DateCreated2001-01-24
DateModified2021-06-02

Ontological Relatives

GenesZNF148

GO terms

Show/Hide Table
GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0003700 DNA-binding transcription factor activity
GO:0005654 nucleoplasm
GO:0005794 Golgi apparatus
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006968 cellular defense response
GO:0007276 gamete generation
GO:0010629 negative regulation of gene expression
GO:0021762 substantia nigra development
GO:0043565 sequence-specific DNA binding
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046872 metal ion binding
GO:0065003 protein-containing complex assembly

Subcellular Location

Show/Hide Table
Subcellular Location
Nucleus

Domains

Show/Hide Table
DomainNameCategoryType
IPR013087 Zinc finger C2H2-typeDomainDomain
IPR036236 Zinc finger C2H2 superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table
Disease IDSourceNameDescription
617260 OMIMGlobal developmental delay, absent or hypoplastic corpus callosum, and dysmorphic facies (GDACCF)An autosomal dominant syndrome characterized by underdevelopment of the corpus callosum, mild to moderate developmental delay and intellectual disability, variable microcephaly or mild macrocephaly, short stature, feeding problems, facial dysmorphisms, and cardiac and renal malformations. The disease is caused by variants affecting the gene represented in this entry.

Interactions

32 interactions

InteractorPartnerSourcesPublicationsLink
ZN148_HUMANDEUP1_HUMANBioGRID, IntAct25416956 details
ZN148_HUMANGLRX3_HUMANBioGRID, IntAct25416956 details
ZN148_HUMANK1H1_HUMANBioGRID, IntAct25416956 details
ZN148_HUMANSIAH1_HUMANBioGRID, IntAct25416956 details
ZN148_HUMANCEP70_HUMANBioGRID, IntAct25416956 details
ZN148_HUMANGORS2_HUMANBioGRID, IntAct25416956 32296183 details
ZN148_HUMANTRI10_HUMANBioGRID, IntAct25416956 details
ZN148_HUMANLNX2_HUMANBioGRID, IntAct27107012 details
ZN148_HUMANUBP54_HUMANBioGRID, IntAct32296183 details
ZN148_HUMANPKHG4_HUMANBioGRID, IntAct32296183 details
ZN148_HUMANZMY12_HUMANBioGRID, IntAct32296183 details
ZN148_HUMANPO6F2_HUMANBioGRID, IntAct32296183 details
ZN148_HUMANJADE1_HUMANBioGRID, IntAct32296183 details
ZN148_HUMANPNMA1_HUMANBioGRID, IntAct32296183 details
ZN148_HUMANCEP63_HUMANBioGRID, IntAct32296183 details
ZN148_HUMANKRT34_HUMANBioGRID, IntAct32296183 details
ZN148_HUMANLNX1_HUMANBioGRID, IntAct32296183 details
ZN148_HUMANPFD5_HUMANBioGRID, IntAct32296183 details
ZN148_HUMANNTM2F_HUMANBioGRID, IntAct25416956 31515488 32296183 details
ZN148_HUMANCAVN1_HUMANBioGRID, HPRD10727401 details
ZN148_HUMANP53_HUMANBioGRID, HPRD11416144 details
ZN148_HUMANUBC_HUMANBioGRID23314748 details
ZN148_HUMANCLK1_HUMANBioGRID26167880 details
ZN148_HUMANHDAC3_HUMANBioGRID, MINT19583777 details
ZN148_HUMANHDAC4_HUMANMINT19583777 details
ZN148_HUMANRXRG_HUMANIntAct20195357 details
ZN148_HUMANHDAC1_HUMANBioGRID17663720 details
ZN148_HUMANEP300_HUMANBioGRID, HPRD10899165 21828133 details
ZN148_HUMANTRRAP_HUMANBioGRID21828133 details
ZN148_HUMANKAT2A_HUMANBioGRID21828133 details
ZN148_HUMANCPSF1_HUMANBioGRID29395067 details
ZN148_HUMANSTAT3_HUMANHPRD14712222 details