Entity Details

Primary name AXIN2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9Y2T1
EntryNameAXIN2_HUMAN
FullNameAxin-2
TaxID9606
Evidenceevidence at protein level
Length843
SequenceStatuscomplete
DateCreated2000-12-01
DateModified2021-06-02

Ontological Relatives

GenesAXIN2

GO terms

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GOName
GO:0001756 somitogenesis
GO:0001934 positive regulation of protein phosphorylation
GO:0001957 intramembranous ossification
GO:0003139 secondary heart field specification
GO:0003413 chondrocyte differentiation involved in endochondral bone morphogenesis
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0008013 beta-catenin binding
GO:0008283 cell population proliferation
GO:0008285 negative regulation of cell population proliferation
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0010942 positive regulation of cell death
GO:0016055 Wnt signaling pathway
GO:0019899 enzyme binding
GO:0030282 bone mineralization
GO:0030877 beta-catenin destruction complex
GO:0031625 ubiquitin protein ligase binding
GO:0032423 regulation of mismatch repair
GO:0034613 cellular protein localization
GO:0042476 odontogenesis
GO:0043570 maintenance of DNA repeat elements
GO:0045668 negative regulation of osteoblast differentiation
GO:0048255 mRNA stabilization
GO:0061181 regulation of chondrocyte development
GO:0070411 I-SMAD binding
GO:0070602 regulation of centromeric sister chromatid cohesion
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:1904837 beta-catenin-TCF complex assembly

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR001158 DIX domainDomainDomain
IPR014936 Axin beta-catenin bindingDomainDomain
IPR016137 RGS domainDomainDomain
IPR024066 RGS, subdomain 1/3FamilyHomologous superfamily
IPR029071 Ubiquitin-like domain superfamilyFamilyHomologous superfamily
IPR032101 Axin-1/2, tankyrase-binding domainDomainDomain
IPR036305 RGS domain superfamilyFamilyHomologous superfamily
IPR038207 DIX domain superfamilyFamilyHomologous superfamily
IPR043581 Axin-likeFamilyFamily

Diseases

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Disease IDSourceNameDescription
608615 OMIMOligodontia-colorectal cancer syndrome (ODCRCS)Affected individuals manifest severe tooth agenesis and colorectal cancer or precancerous lesions of variable types. The disease is caused by variants affecting the gene represented in this entry.
114500 OMIMColorectal cancer (CRC)A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history. The gene represented in this entry is involved in disease pathogenesis.

Interactions

69 interactions

InteractorPartnerSourcesPublicationsLink
AXIN2_HUMANCTNB1_HUMANbhf-ucl, BioGRID, DIP, HPRD, IntAct10966653 15304487 17510365 22014570 22056988 27684187 9566905 details
AXIN2_HUMANPP2AB_HUMANMINT10698523 details
AXIN2_HUMANGSK3B_HUMANBioGRID, HPRD, IntAct, UniProt10966653 12183362 23455922 23602568 29568061 30824926 9566905 details
AXIN2_HUMANGSK3A_HUMANBioGRID, IntAct, UniProt23602568 30824926 details
AXIN2_HUMANKCNKC_HUMANBioGRID, MINT24412244 details
AXIN2_HUMANRAGP1_HUMANBioGRID, MINT24412244 details
AXIN2_HUMANPRDX1_HUMANBioGRID, MINT24412244 details
AXIN2_HUMANF16P1_HUMANBioGRID, MINT24412244 details
AXIN2_HUMANSMAD1_HUMANBioGRID, MINT24412244 details
AXIN2_HUMANF16P2_HUMANBioGRID, MINT24412244 details
AXIN2_HUMANHEMGN_HUMANBioGRID, MINT24412244 details
AXIN2_HUMANTGFB1_HUMANBioGRID, MINT24412244 details
AXIN2_HUMANZN189_HUMANBioGRID, MINT24412244 details
AXIN2_HUMANTGIF1_HUMANIntAct25873176 details
AXIN2_HUMANFBW1A_HUMANBioGRID, IntAct32296183 details
AXIN2_HUMANTXLNB_HUMANBioGRID, IntAct32296183 details
AXIN2_HUMANCHIC2_HUMANBioGRID, IntAct32296183 details
AXIN2_HUMANZN648_HUMANBioGRID, IntAct32296183 details
AXIN2_HUMANBARD1_HUMANBioGRID, IntAct32296183 details
AXIN2_HUMANKIFC3_HUMANBioGRID, IntAct32296183 details
AXIN2_HUMANSCNM1_HUMANBioGRID, IntAct32296183 details
AXIN2_HUMANMCRS1_HUMANBioGRID, IntAct32296183 details
AXIN2_HUMANTXLNA_HUMANBioGRID, IntAct32296183 details
AXIN2_HUMANZN124_HUMANBioGRID, IntAct32296183 details
AXIN2_HUMANCC112_HUMANBioGRID, IntAct32296183 details
AXIN2_HUMANZN417_HUMANBioGRID, IntAct32296183 details
AXIN2_HUMANKRA45_HUMANBioGRID, IntAct32296183 details
AXIN2_HUMANPSB2_HUMANBioGRID, IntAct32296183 details
AXIN2_HUMANKR10A_HUMANBioGRID, IntAct32296183 details
AXIN2_HUMANSTX11_HUMANBioGRID, IntAct32296183 details
AXIN2_HUMANBYST_HUMANBioGRID, IntAct32296183 details
AXIN2_HUMANCTAG2_HUMANBioGRID, IntAct32296183 details
AXIN2_HUMANKR108_HUMANBioGRID, IntAct32296183 details
AXIN2_HUMANF161A_HUMANBioGRID, IntAct32296183 details
AXIN2_HUMANHXB5_HUMANBioGRID, IntAct32296183 details
AXIN2_HUMANTSG10_HUMANBioGRID, IntAct32296183 details
AXIN2_HUMANC19L2_HUMANBioGRID, IntAct32296183 details
AXIN2_HUMANTOP3B_HUMANBioGRID, IntAct32296183 details
AXIN2_HUMANZN587_HUMANBioGRID, IntAct32296183 details
AXIN2_HUMANLNX1_HUMANBioGRID, IntAct32296183 details
AXIN2_HUMANELOA1_HUMANBioGRID, IntAct32296183 details
AXIN2_HUMANTEANC_HUMANBioGRID, IntAct32296183 details
AXIN2_HUMANTCEA2_HUMANBioGRID, IntAct32296183 details
AXIN2_HUMANCAN7_HUMANBioGRID, IntAct32296183 details
AXIN2_HUMAN2A5A_HUMANBioGRID, IntAct32296183 details
AXIN2_HUMANAP1M1_HUMANBioGRID, IntAct32296183 details
AXIN2_HUMANCB068_HUMANBioGRID, IntAct32296183 details
AXIN2_HUMANKRA92_HUMANBioGRID, IntAct32296183 details
AXIN2_HUMANAPCL_HUMANBioGRID10021369 details
AXIN2_HUMANAPC_HUMANBioGRID, HPRD10966653 details
AXIN2_HUMANANKR6_HUMANBioGRID, HPRD12183362 details
AXIN2_HUMANSMAD7_HUMANBioGRID24584437 27292644 details
AXIN2_HUMANAMOT_HUMANBioGRID32296183 details
AXIN2_HUMANAMMR1_HUMANMINT21304492 details
AXIN2_HUMANCDC20_HUMANBioGRID, MINT22322943 details
AXIN2_HUMANAXIN1_HUMANBioGRID, IntAct20128690 22682247 details
AXIN2_HUMANAMER3_HUMANMINT24251807 details
AXIN2_HUMANPLK1_HUMANDIP16815967 details
AXIN2_HUMANFXR1_HUMANMINT21653829 details
AXIN2_HUMANFXR2_HUMANMINT21653829 details
AXIN2_HUMANKDM5B_HUMANBioGRID19336002 details
AXIN2_HUMANRN146_HUMANBioGRID21478859 27521426 details
AXIN2_HUMANNR4A1_HUMANBioGRID24584437 details
AXIN2_HUMANRNF12_HUMANBioGRID24584437 details
AXIN2_HUMANRN111_HUMANBioGRID24584437 details
AXIN2_HUMANM3K2_HUMANBioGRID26884171 details
AXIN2_HUMANSIAH1_HUMANBioGRID28546513 details
AXIN2_HUMANKC1E_HUMANHPRD12183362 details
AXIN2_HUMANSMAD3_HUMANHPRD11438668 details