Entity Details

Primary name FADS1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO60427
EntryNameFADS1_HUMAN
FullNameAcyl-CoA (8-3)-desaturase
TaxID9606
Evidenceevidence at protein level
Length444
SequenceStatuscomplete
DateCreated2007-10-02
DateModified2021-06-02

Ontological Relatives

GenesFADS1

GO terms

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GOName
GO:0000248 C-5 sterol desaturase activity
GO:0005739 mitochondrion
GO:0005789 endoplasmic reticulum membrane
GO:0006355 regulation of transcription, DNA-templated
GO:0006636 unsaturated fatty acid biosynthetic process
GO:0007267 cell-cell signaling
GO:0008654 phospholipid biosynthetic process
GO:0009267 cellular response to starvation
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016213 linoleoyl-CoA desaturase activity
GO:0016491 oxidoreductase activity
GO:0019222 regulation of metabolic process
GO:0036109 alpha-linolenic acid metabolic process
GO:0042759 long-chain fatty acid biosynthetic process
GO:0043231 intracellular membrane-bounded organelle
GO:0043651 linoleic acid metabolic process
GO:0045595 regulation of cell differentiation
GO:0046456 icosanoid biosynthetic process
GO:0062076 acyl-CoA delta5-desaturase activity

Subcellular Location

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Subcellular Location
Endoplasmic reticulum membrane
Mitochondrion

Domains

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DomainNameCategoryType
IPR001199 Cytochrome b5-like heme/steroid binding domainDomainDomain
IPR005804 Fatty acid desaturase domainDomainDomain
IPR012171 Fatty acid desaturaseFamilyFamily
IPR036400 Cytochrome b5-like heme/steroid binding domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00132 alpha-Linolenic acidDrugbanksmall molecule
DB00159 IcosapentDrugbanksmall molecule
DB09328 VayarinSwissprotbiotech
DB11358 Evening primrose oilSwissprotbiotech
DB13168 Omega-6 fatty acidsSwissprotsmall molecule

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
FADS1_HUMANXRN1_HUMANBioGRID15231747 details