Entity Details

Primary name VPS4B_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO75351
EntryNameVPS4B_HUMAN
FullNameVacuolar protein sorting-associated protein 4B
TaxID9606
Evidenceevidence at protein level
Length444
SequenceStatuscomplete
DateCreated2000-12-01
DateModified2021-06-02

Ontological Relatives

GenesVPS4B

GO terms

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GOName
GO:0000922 spindle pole
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005813 centrosome
GO:0005829 cytosol
GO:0006813 potassium ion transport
GO:0006997 nucleus organization
GO:0007080 mitotic metaphase plate congression
GO:0008022 protein C-terminus binding
GO:0008568 microtubule-severing ATPase activity
GO:0010008 endosome membrane
GO:0010824 regulation of centrosome duplication
GO:0010971 positive regulation of G2/M transition of mitotic cell cycle
GO:0015031 protein transport
GO:0016197 endosomal transport
GO:0016236 macroautophagy
GO:0016887 ATP hydrolysis activity
GO:0019058 viral life cycle
GO:0019076 viral release from host cell
GO:0030301 cholesterol transport
GO:0031122 cytoplasmic microtubule organization
GO:0031902 late endosome membrane
GO:0032510 endosome to lysosome transport via multivesicular body sorting pathway
GO:0033993 response to lipid
GO:0036258 multivesicular body assembly
GO:0039702 viral budding via host ESCRT complex
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO:0044877 protein-containing complex binding
GO:0048524 positive regulation of viral process
GO:0050792 regulation of viral process
GO:0051261 protein depolymerization
GO:0060548 negative regulation of cell death
GO:0061738 late endosomal microautophagy
GO:0061952 midbody abscission
GO:0070062 extracellular exosome
GO:0090543 Flemming body
GO:0090611 ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway
GO:1901673 regulation of mitotic spindle assembly
GO:1902188 positive regulation of viral release from host cell
GO:1903542 negative regulation of exosomal secretion
GO:1903543 positive regulation of exosomal secretion
GO:1903724 positive regulation of centriole elongation
GO:1903902 positive regulation of viral life cycle
GO:1904903 ESCRT III complex disassembly

Subcellular Location

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Subcellular Location
Late endosome membrane

Domains

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DomainNameCategoryType
IPR003593 AAA+ ATPase domainDomainDomain
IPR003959 ATPase, AAA-type, coreDomainDomain
IPR003960 ATPase, AAA-type, conserved siteSiteConserved site
IPR007330 MIT domainDomainDomain
IPR015415 Vps4 oligomerisation, C-terminalDomainDomain
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR031255 Vacuolar protein sorting-associated protein 4FamilyFamily
IPR036181 MIT domain superfamilyFamilyHomologous superfamily
IPR041569 AAA ATPase, AAA+ lid domainDomainDomain

Diseases

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