Entity Details

Primary name DPOLQ_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO75417
EntryNameDPOLQ_HUMAN
FullNameDNA polymerase theta
TaxID9606
Evidenceevidence at protein level
Length2590
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesPOLQ

GO terms

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GOName
GO:0000724 double-strand break repair via homologous recombination
GO:0003682 chromatin binding
GO:0003684 damaged DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0005524 ATP binding
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0006261 DNA-dependent DNA replication
GO:0006281 DNA repair
GO:0006284 base-excision repair
GO:0006302 double-strand break repair
GO:0006974 cellular response to DNA damage stimulus
GO:0008409 5'-3' exonuclease activity
GO:0016446 somatic hypermutation of immunoglobulin genes
GO:0017116 single-stranded DNA helicase activity
GO:0042802 identical protein binding
GO:0051260 protein homooligomerization
GO:0051575 5'-deoxyribose-5-phosphate lyase activity
GO:0097681 double-strand break repair via alternative nonhomologous end joining
GO:2000042 negative regulation of double-strand break repair via homologous recombination

Subcellular Location

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Subcellular Location
Chromosome
Nucleus

Domains

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DomainNameCategoryType
IPR001098 DNA-directed DNA polymerase, family A, palm domainDomainDomain
IPR001650 Helicase, C-terminalDomainDomain
IPR002298 DNA polymerase AFamilyFamily
IPR011545 DEAD/DEAH box helicase domainDomainDomain
IPR012337 Ribonuclease H-like superfamilyFamilyHomologous superfamily
IPR014001 Helicase superfamily 1/2, ATP-binding domainDomainDomain
IPR019760 DNA-directed DNA polymerase, family A, conserved siteSiteConserved site
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR036397 Ribonuclease H superfamilyFamilyHomologous superfamily
IPR043502 DNA/RNA polymerase superfamilyFamilyHomologous superfamily

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
DPOLQ_HUMANRAD51_HUMANDIP25642963 details
DPOLQ_HUMANDPOLQ_HUMANDIP26636256 details