Entity Details

Primary name CP7B1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO75881
EntryNameCP7B1_HUMAN
FullNameCytochrome P450 7B1
TaxID9606
Evidenceevidence at protein level
Length506
SequenceStatuscomplete
DateCreated1999-07-15
DateModified2021-06-02

Ontological Relatives

GenesCYP7B1

GO terms

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GOName
GO:0005506 iron ion binding
GO:0005789 endoplasmic reticulum membrane
GO:0006699 bile acid biosynthetic process
GO:0008203 cholesterol metabolic process
GO:0008395 steroid hydroxylase activity
GO:0008396 oxysterol 7-alpha-hydroxylase activity
GO:0016021 integral component of membrane
GO:0016125 sterol metabolic process
GO:0020037 heme binding
GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway
GO:0033783 25-hydroxycholesterol 7alpha-hydroxylase activity
GO:0035754 B cell chemotaxis
GO:0042632 cholesterol homeostasis
GO:0047092 27-hydroxycholesterol 7-alpha-monooxygenase activity
GO:0050679 positive regulation of epithelial cell proliferation
GO:0060740 prostate gland epithelium morphogenesis

Subcellular Location

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Subcellular Location
Endoplasmic reticulum membrane
Microsome membrane

Domains

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DomainNameCategoryType
IPR001128 Cytochrome P450FamilyFamily
IPR002403 Cytochrome P450, E-class, group IVFamilyFamily
IPR024204 Cytochrome P450, cholesterol 7-alpha-monooxygenase-typeFamilyFamily
IPR036396 Cytochrome P450 superfamilyFamilyHomologous superfamily

Diseases

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Interactions

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