Entity Details

Primary name AP2A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP05549
EntryNameAP2A_HUMAN
FullNameTranscription factor AP-2-alpha
TaxID9606
Evidenceevidence at protein level
Length437
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesTFAP2A

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001822 kidney development
GO:0003404 optic vesicle morphogenesis
GO:0003409 optic cup structural organization
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007605 sensory perception of sound
GO:0008285 negative regulation of cell population proliferation
GO:0010628 positive regulation of gene expression
GO:0010842 retina layer formation
GO:0010944 negative regulation of transcription by competitive promoter binding
GO:0021559 trigeminal nerve development
GO:0021623 oculomotor nerve formation
GO:0030501 positive regulation of bone mineralization
GO:0035115 embryonic forelimb morphogenesis
GO:0042127 regulation of cell population proliferation
GO:0042472 inner ear morphogenesis
GO:0042802 identical protein binding
GO:0043066 negative regulation of apoptotic process
GO:0043525 positive regulation of neuron apoptotic process
GO:0043565 sequence-specific DNA binding
GO:0045595 regulation of cell differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0048856 anatomical structure development
GO:0060021 roof of mouth development
GO:0060349 bone morphogenesis
GO:0061029 eyelid development in camera-type eye
GO:0070172 positive regulation of tooth mineralization
GO:0071281 cellular response to iron ion
GO:0140536 nuclear receptor corepressor activity
GO:1990837 sequence-specific double-stranded DNA binding
GO:2000378 negative regulation of reactive oxygen species metabolic process

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR004979 Transcription factor AP-2FamilyFamily
IPR008121 Transcription factor AP-2 alpha, N-terminalDomainDomain
IPR013854 Transcription factor AP-2, C-terminalDomainDomain

Diseases

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Disease IDSourceNameDescription
113620 OMIMBranchiooculofacial syndrome (BOFS)A syndrome characterized by growth retardation, bilateral branchial sinus defects with hemangiomatous, scarred skin, cleft lip with or without cleft palate, pseudocleft of the upper lip, nasolacrimal duct obstruction, low set ears with posterior rotation, a malformed, asymmetrical nose with a broad bridge and flattened tip, conductive or sensorineural deafness, ocular and renal anomalies. The disease is caused by variants affecting the gene represented in this entry.

Interactions

134 interactions

InteractorPartnerSourcesPublicationsLink
AP2A_HUMANUBC9_HUMANBioGRID, IntAct12072434 24835590 details
AP2A_HUMANEP300_HUMANBioGRID, HPRD, IntAct12586840 25669978 details
AP2A_HUMANCITE2_HUMANBioGRID, HPRD, IntAct11744733 12586840 details
AP2A_HUMANNPM_HUMANBioGRID, HPRD, MINT17318229 19074833 details
AP2A_HUMANTENXA_HUMANIntAct24835590 details
AP2A_HUMANTENX_HUMANIntAct24835590 details
AP2A_HUMANMT2_HUMANIntAct24835590 details
AP2A_HUMANLOXL1_HUMANIntAct24835590 details
AP2A_HUMANIFI27_HUMANIntAct24835590 details
AP2A_HUMANFHL2_HUMANIntAct24835590 details
AP2A_HUMANZN326_HUMANIntAct24835590 details
AP2A_HUMANZMYM2_HUMANIntAct24835590 details
AP2A_HUMANTBB2A_HUMANIntAct24835590 details
AP2A_HUMANTOX3_HUMANIntAct24835590 details
AP2A_HUMANTMPS5_HUMANIntAct24835590 details
AP2A_HUMANSERHL_HUMANIntAct24835590 details
AP2A_HUMANRSSA_HUMANIntAct24835590 details
AP2A_HUMANRERE_HUMANIntAct24835590 details
AP2A_HUMANPPME1_HUMANIntAct24835590 details
AP2A_HUMANRANB9_HUMANIntAct24835590 details
AP2A_HUMANLAMA5_HUMANIntAct24835590 details
AP2A_HUMANTHTM_HUMANIntAct24835590 details
AP2A_HUMANMORN1_HUMANIntAct24835590 details
AP2A_HUMANMOB3C_HUMANIntAct24835590 details
AP2A_HUMANLDHA_HUMANIntAct24835590 details
AP2A_HUMANDBF4B_HUMANIntAct24835590 details
AP2A_HUMANCBPE_HUMANIntAct24835590 details
AP2A_HUMANCDK5_HUMANIntAct24835590 details
AP2A_HUMANATPA_HUMANIntAct24835590 details
AP2A_HUMANC1QC_HUMANIntAct24835590 details
AP2A_HUMANARSA_HUMANIntAct24835590 details
AP2A_HUMANFCGBP_HUMANIntAct24835590 details
AP2A_HUMANA16A1_HUMANIntAct24835590 details
AP2A_HUMANCCN5_HUMANIntAct24835590 details
AP2A_HUMANFBLN1_HUMANIntAct24835590 details
AP2A_HUMANI27L2_HUMANIntAct24835590 details
AP2A_HUMANEYA2_HUMANBioGRID, IntAct24835590 27880917 details
AP2A_HUMANDPP2_HUMANIntAct24835590 details
AP2A_HUMANCO1A1_HUMANIntAct24835590 details
AP2A_HUMANCO1A2_HUMANIntAct24835590 details
AP2A_HUMANCOFA1_HUMANIntAct24835590 details
AP2A_HUMANCCD80_HUMANIntAct24835590 details
AP2A_HUMANCFAH_HUMANIntAct24835590 details
AP2A_HUMANZN641_HUMANIntAct24835590 details
AP2A_HUMANACTN4_HUMANIntAct24835590 details
AP2A_HUMANDCAF7_HUMANIntAct24835590 details
AP2A_HUMANUNKL_HUMANIntAct24835590 details
AP2A_HUMANTCTP_HUMANIntAct24835590 details
AP2A_HUMANTIM50_HUMANIntAct24835590 details
AP2A_HUMANTHY1_HUMANIntAct24835590 details
AP2A_HUMANSNTA1_HUMANIntAct24835590 details
AP2A_HUMANRCC1L_HUMANIntAct24835590 details
AP2A_HUMANRL15_HUMANIntAct24835590 details
AP2A_HUMANERI3_HUMANIntAct24835590 details
AP2A_HUMANPOTEF_HUMANIntAct24835590 details
AP2A_HUMANRHOA_HUMANIntAct24835590 details
AP2A_HUMANPA24B_HUMANIntAct24835590 details
AP2A_HUMANKLF10_HUMANIntAct24835590 details
AP2A_HUMANGLNA_HUMANIntAct24835590 details
AP2A_HUMANTIM14_HUMANIntAct24835590 details
AP2A_HUMANCTBP1_HUMANIntAct24835590 details
AP2A_HUMANMCAF1_HUMANIntAct24835590 details
AP2A_HUMANALDOA_HUMANIntAct24835590 details
AP2A_HUMANACY1_HUMANIntAct24835590 details
AP2A_HUMANDMRT3_HUMANIntAct24835590 details
AP2A_HUMANACTA_HUMANIntAct24835590 details
AP2A_HUMANPIAS1_HUMANIntAct24835590 details
AP2A_HUMANPELI1_HUMANIntAct24835590 details
AP2A_HUMANNOMO3_HUMANIntAct24835590 details
AP2A_HUMANLEG1_HUMANIntAct24835590 details
AP2A_HUMANIN35_HUMANIntAct24835590 details
AP2A_HUMANHYI_HUMANIntAct24835590 details
AP2A_HUMANMOB2_HUMANIntAct24835590 details
AP2A_HUMANGBB2_HUMANIntAct24835590 details
AP2A_HUMANMKRN3_HUMANBioGRID, IntAct25416956 details
AP2A_HUMANGSTO2_HUMANBioGRID, IntAct25416956 25910212 31515488 32296183 details
AP2A_HUMANINCA1_HUMANBioGRID, IntAct32296183 details
AP2A_HUMANP53_HUMANBioGRID, HPRD12226108 16288208 details
AP2A_HUMANAPC_HUMANBioGRID, HPRD15331612 details
AP2A_HUMANCITE4_HUMANBioGRID, HPRD11744733 details
AP2A_HUMANMYC_HUMANBioGRID7729426 details
AP2A_HUMANYBOX1_HUMANBioGRID, HPRD11973333 9830047 details
AP2A_HUMANPPARG_HUMANBioGRID18310298 details
AP2A_HUMANEPN1_HUMANBioGRID15809337 16497222 details
AP2A_HUMANKCTD1_HUMANBioGRID19115315 details
AP2A_HUMANEPS15_HUMANBioGRID18524853 9490719 details
AP2A_HUMANSRA1_HUMANBioGRID20398657 details
AP2A_HUMANRB_HUMANBioGRID, HPRD9632747 details
AP2A_HUMANSP1_HUMANBioGRID15705965 19074833 22182699 details
AP2A_HUMANKCD15_HUMANBioGRID23382213 29665387 details
AP2A_HUMANAAPK2_HUMANBioGRID22561688 details
AP2A_HUMANCSK2B_HUMANBioGRID21777522 details
AP2A_HUMANCSK21_HUMANBioGRID21777522 details
AP2A_HUMANXRCC6_HUMANBioGRID19906305 details
AP2A_HUMANXRCC5_HUMANBioGRID19906305 details
AP2A_HUMANTF65_HUMANBioGRID19074833 details
AP2A_HUMANNFKB1_HUMANBioGRID19074833 details
AP2A_HUMANKPCD1_HUMANBioGRID18845787 details
AP2A_HUMANVEGFA_HUMANBioGRID15342781 details
AP2A_HUMANSH3B4_HUMANBioGRID, MINT16325581 details
AP2A_HUMANCTNB1_HUMANBioGRID, HPRD15331612 details
AP2A_HUMANDEK_HUMANBioGRID, HPRD12595566 details
AP2A_HUMANTYY1_HUMANBioGRID15870067 details
AP2A_HUMANDNM3A_HUMANBioGRID19786833 details
AP2A_HUMANBRCA1_HUMANBioGRID21363924 details
AP2A_HUMANAURKA_HUMANBioGRID21829699 details
AP2A_HUMANEPAS1_HUMANBioGRID23275444 details
AP2A_HUMANDAB2_HUMANBioGRID22323290 details
AP2A_HUMANERBB4_HUMANBioGRID20943952 details
AP2A_HUMANAP2C_HUMANBioGRID20459791 details
AP2A_HUMANCFTR_HUMANBioGRID20351096 details
AP2A_HUMANAP2B_HUMANBioGRID18843039 details
AP2A_HUMANAP2B1_HUMANBioGRID12900408 18843039 details
AP2A_HUMANAP1M2_HUMANBioGRID18843039 details
AP2A_HUMANGCR_HUMANBioGRID28611094 31182584 details
AP2A_HUMANANDR_HUMANBioGRID28611094 details
AP2A_HUMANH33_HUMANBioGRID23828041 details
AP2A_HUMANFCHO1_HUMANBioGRID27237791 details
AP2A_HUMANEGFR_HUMANBioGRID8662849 details
AP2A_HUMANADRB2_HUMANBioGRID12163475 details
AP2A_HUMANAP2M1_HUMANBioGRID12900408 details
AP2A_HUMANMEG10_HUMANBioGRID17643423 details
AP2A_HUMANCASP1_HUMANHPRD11438643 details
AP2A_HUMANCASP3_HUMANHPRD11438643 details
AP2A_HUMANCASP6_HUMANHPRD11438643 details
AP2A_HUMANWWP1_HUMANHPRD9169421 details
AP2A_HUMANWWP2_HUMANHPRD9169421 details
AP2A_HUMANMAGI1_HUMANHPRD9169421 details
AP2A_HUMANARH_HUMANHPRD12221107 details
AP2A_HUMANEPN2_HUMANHPRD10567358 details
AP2A_HUMANSYT1_HUMANHPRD8087843 details
AP2A_HUMANHIP1_HUMANHPRD11604514 details
AP2A_HUMANCLH1_HUMANHPRD1587861 details
AP2A_HUMANSUMO4_HUMANHPRD16236267 details