Entity Details

Primary name PLEK_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP08567
EntryNamePLEK_HUMAN
FullNamePleckstrin
TaxID9606
Evidenceevidence at protein level
Length350
SequenceStatuscomplete
DateCreated1988-08-01
DateModified2021-06-02

Ontological Relatives

GenesPLEK

GO terms

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GOName
GO:0002244 hematopoietic progenitor cell differentiation
GO:0002576 platelet degranulation
GO:0005080 protein kinase C binding
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006904 vesicle docking involved in exocytosis
GO:0007229 integrin-mediated signaling pathway
GO:0010572 positive regulation of platelet activation
GO:0010920 negative regulation of inositol phosphate biosynthetic process
GO:0010925 positive regulation of inositol-polyphosphate 5-phosphatase activity
GO:0016020 membrane
GO:0030030 cell projection organization
GO:0030836 positive regulation of actin filament depolymerization
GO:0030845 phospholipase C-inhibiting G protein-coupled receptor signaling pathway
GO:0030866 cortical actin cytoskeleton organization
GO:0031529 ruffle organization
GO:0031532 actin cytoskeleton reorganization
GO:0032233 positive regulation of actin filament bundle assembly
GO:0032587 ruffle membrane
GO:0033625 positive regulation of integrin activation
GO:0042803 protein homodimerization activity
GO:0043325 phosphatidylinositol-3,4-bisphosphate binding
GO:0045744 negative regulation of G protein-coupled receptor signaling pathway
GO:0046488 phosphatidylinositol metabolic process
GO:0050849 negative regulation of calcium-mediated signaling
GO:0060305 regulation of cell diameter
GO:0070493 thrombin-activated receptor signaling pathway
GO:0070527 platelet aggregation
GO:0070528 protein kinase C signaling
GO:0070560 protein secretion by platelet

Subcellular Location

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Domains

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DomainNameCategoryType
IPR000591 DEP domainDomainDomain
IPR001849 Pleckstrin homology domainDomainDomain
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR036388 Winged helix-like DNA-binding domain superfamilyFamilyHomologous superfamily
IPR036390 Winged helix DNA-binding domain superfamilyFamilyHomologous superfamily
IPR037371 Pleckstrin 1, DEP domainDomainDomain

Diseases

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