Entity Details

Primary name TYPH_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP19971
EntryNameTYPH_HUMAN
FullNameThymidine phosphorylase
TaxID9606
Evidenceevidence at protein level
Length482
SequenceStatuscomplete
DateCreated1991-02-01
DateModified2021-06-02

Ontological Relatives

GenesTYMP

GO terms

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GOName
GO:0000002 mitochondrial genome maintenance
GO:0001525 angiogenesis
GO:0004645 1,4-alpha-oligoglucan phosphorylase activity
GO:0005829 cytosol
GO:0006206 pyrimidine nucleobase metabolic process
GO:0006213 pyrimidine nucleoside metabolic process
GO:0006935 chemotaxis
GO:0008083 growth factor activity
GO:0009032 thymidine phosphorylase activity
GO:0016154 pyrimidine-nucleoside phosphorylase activity
GO:0030154 cell differentiation
GO:0031641 regulation of myelination
GO:0042803 protein homodimerization activity
GO:0043097 pyrimidine nucleoside salvage
GO:0046074 dTMP catabolic process
GO:0046135 pyrimidine nucleoside catabolic process
GO:0051969 regulation of transmission of nerve impulse
GO:1905333 regulation of gastric motility

Subcellular Location

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Domains

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DomainNameCategoryType
IPR000053 Thymidine/pyrimidine-nucleoside phosphorylaseFamilyFamily
IPR000312 Glycosyl transferase, family 3DomainDomain
IPR013102 Pyrimidine nucleoside phosphorylase, C-terminalDomainDomain
IPR017459 Glycosyl transferase family 3, N-terminal domainDomainDomain
IPR017872 Pyrimidine-nucleoside phosphorylase, conserved siteSiteConserved site
IPR018090 Pyrimidine-nucleoside phosphorylase, bacterial/eukaryoticFamilyFamily
IPR035902 Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain superfamilyFamilyHomologous superfamily
IPR036320 Glycosyl transferase family 3, N-terminal domain superfamilyFamilyHomologous superfamily
IPR036566 Pyrimidine nucleoside phosphorylase-like, C-terminal domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00322 FloxuridineDrugbanksmall molecule
DB00369 CidofovirDrugbanksmall molecule
DB00432 TrifluridineDrugbanksmall molecule
DB00544 FluorouracilDrugbanksmall molecule
DB01101 CapecitabineDrugbanksmall molecule
DB06433 TezacitabineDrugbanksmall molecule
DB09343 TipiracilDrugbanksmall molecule

Interactions

5 interactions

InteractorPartnerSourcesPublicationsLink
TYPH_HUMANTYPH_HUMANBioGRID, HPRD, IntAct1590793 25416956 details
TYPH_HUMANZMY12_HUMANBioGRID, IntAct32296183 details
TYPH_HUMANMESD_HUMANBioGRID, IntAct32296183 details
TYPH_HUMANERBB2_HUMANBioGRID, IntAct31980649 details
TYPH_HUMANHS90A_HUMANBioGRID22480737 details