Entity Details

Primary name GDIA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP31150
EntryNameGDIA_HUMAN
FullNameRab GDP dissociation inhibitor alpha
TaxID9606
Evidenceevidence at protein level
Length447
SequenceStatuscomplete
DateCreated1993-07-01
DateModified2021-06-02

Ontological Relatives

GenesGDI1

GO terms

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GOName
GO:0005092 GDP-dissociation inhibitor activity
GO:0005093 Rab GDP-dissociation inhibitor activity
GO:0005096 GTPase activator activity
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0007165 signal transduction
GO:0015031 protein transport
GO:0016192 vesicle-mediated transport
GO:0030424 axon
GO:0030496 midbody
GO:0031267 small GTPase binding
GO:0032482 Rab protein signal transduction
GO:0032991 protein-containing complex
GO:0043025 neuronal cell body
GO:0043209 myelin sheath
GO:0043547 positive regulation of GTPase activity
GO:0045773 positive regulation of axon extension
GO:0050771 negative regulation of axonogenesis
GO:0051592 response to calcium ion
GO:0090315 negative regulation of protein targeting to membrane

Subcellular Location

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Subcellular Location
Cytoplasm
Golgi apparatus

Domains

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DomainNameCategoryType
IPR000806 Rab GDI proteinFamilyFamily
IPR018203 GDP dissociation inhibitorFamilyFamily
IPR036188 FAD/NAD(P)-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
300849 OMIMMental retardation, X-linked 41 (MRX41)A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations. The disease is caused by variants affecting the gene represented in this entry.

Interactions

28 interactions

InteractorPartnerSourcesPublicationsLink
GDIA_HUMANUBQL4_HUMANBioGRID, HPRD, IntAct16713569 details
GDIA_HUMANGNL1_HUMANBioGRID, IntAct18255255 details
GDIA_HUMANKITH_HUMANBioGRID, MINT21900206 details
GDIA_HUMANRAB4A_HUMANBioGRID, IntAct, UniProt19570034 26496610 28514442 34079125 details
GDIA_HUMANLNX1_HUMANBioGRID, IntAct25416956 25910212 details
GDIA_HUMANRAB9A_HUMANBioGRID, HPRD, IntAct26496610 28514442 34079125 7744738 details
GDIA_HUMANRAB3B_HUMANBioGRID11741295 details
GDIA_HUMANCDC42_HUMANBioGRID, HPRD11583574 details
GDIA_HUMANOGT1_HUMANBioGRID32994395 details
GDIA_HUMANEPB41_HUMANHPRD16368544 details
GDIA_HUMANFBX11_HUMANIntAct17353931 details
GDIA_HUMANTRM7_HUMANIntAct17353931 details
GDIA_HUMANHLAB_HUMANIntAct17353931 details
GDIA_HUMAN1433Z_HUMANMINT15161933 details
GDIA_HUMANRAB1A_HUMANBioGRID, IntAct, MINT19942850 22939629 26344197 26496610 28514442 details
GDIA_HUMANRAB7A_HUMANBioGRID, IntAct26496610 28514442 29360040 details
GDIA_HUMANRAB6A_HUMANBioGRID, HPRD, IntAct26496610 28514442 8175798 details
GDIA_HUMANSOAT1_HUMANBioGRID, IntAct27173435 unassigned1312 details
GDIA_HUMANNDUS1_HUMANBioGRID, IntAct27173435 unassigned1312 details
GDIA_HUMANACAP2_HUMANBioGRID, IntAct27173435 unassigned1312 details
GDIA_HUMANRAB1B_HUMANBioGRID, HPRD, IntAct26186194 28514442 8836150 details
GDIA_HUMANDISC1_HUMANIntAct31413325 details
GDIA_HUMANMIC10_HUMANBioGRID22114354 details
GDIA_HUMANRHOH_HUMANHPRD11809807 details
GDIA_HUMANRAC2_HUMANHPRD9490022 details
GDIA_HUMANPRAF1_HUMANHPRD10751420 details
GDIA_HUMANRB27A_HUMANHPRD12802062 details
GDIA_HUMANPSN1_HUMANHPRD15480879 details