Entity Details

Primary name HPPD_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP32754
EntryNameHPPD_HUMAN
FullName4-hydroxyphenylpyruvate dioxygenase
TaxID9606
Evidenceevidence at protein level
Length393
SequenceStatuscomplete
DateCreated1993-10-01
DateModified2021-06-02

Ontological Relatives

GenesHPD

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0003868 4-hydroxyphenylpyruvate dioxygenase activity
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0006559 L-phenylalanine catabolic process
GO:0006572 tyrosine catabolic process
GO:0046872 metal ion binding
GO:0070062 extracellular exosome

Subcellular Location

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Domains

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DomainNameCategoryType
IPR004360 Glyoxalase/fosfomycin resistance/dioxygenase domainDomainDomain
IPR005956 4-hydroxyphenylpyruvate dioxygenaseFamilyFamily
IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenaseFamilyHomologous superfamily
IPR037523 Vicinal oxygen chelate (VOC) domainDomainDomain
IPR041735 4-hydroxyphenylpyruvate dioxygenase, C-terminalDomainDomain
IPR041736 4-hydroxyphenylpyruvate dioxygenase, N-terminalDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00348 NitisinoneDrugbanksmall molecule
DB02850 DAS869Drugbanksmall molecule