Entity Details

Primary name CD70_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP32970
EntryNameCD70_HUMAN
FullNameCD70 antigen
TaxID9606
Evidenceevidence at protein level
Length193
SequenceStatuscomplete
DateCreated1993-10-01
DateModified2021-06-02

Ontological Relatives

GenesCD70

GO terms

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GOName
GO:0002020 protease binding
GO:0002456 T cell mediated immunity
GO:0005102 signaling receptor binding
GO:0005125 cytokine activity
GO:0005164 tumor necrosis factor receptor binding
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007165 signal transduction
GO:0007267 cell-cell signaling
GO:0019724 B cell mediated immunity
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0042100 B cell proliferation
GO:0042102 positive regulation of T cell proliferation
GO:0070062 extracellular exosome
GO:0097191 extrinsic apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Membrane

Domains

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DomainNameCategoryType
IPR006052 Tumour necrosis factor domainDomainDomain
IPR008983 Tumour necrosis factor-like domain superfamilyFamilyHomologous superfamily
IPR021184 Tumour necrosis factor, conserved siteSiteConserved site
IPR042374 CD70 antigenFamilyFamily

Diseases

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Disease IDSourceNameDescription
618261 OMIMLymphoproliferative syndrome 3 (LPFS3)An autosomal recessive, early-onset immunologic disorder characterized by increased susceptibility to Epstein-Barr virus infection in B cells, abnormal B-cell proliferation and increased susceptibility to B-cell malignancies, including Hodgkin lymphoma. Patients usually have lymphadenopathy and hypogammaglobulinemia, and may suffer from recurrent infections. The disease is caused by variants affecting the gene represented in this entry.

Interactions

2 interactions