Entity Details

Primary name GSHB_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP48637
EntryNameGSHB_HUMAN
FullNameGlutathione synthetase
TaxID9606
Evidenceevidence at protein level
Length474
SequenceStatuscomplete
DateCreated1996-02-01
DateModified2021-06-02

Ontological Relatives

GenesGSS

GO terms

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GOName
GO:0000287 magnesium ion binding
GO:0004363 glutathione synthase activity
GO:0005524 ATP binding
GO:0005829 cytosol
GO:0006520 cellular amino acid metabolic process
GO:0006750 glutathione biosynthetic process
GO:0006979 response to oxidative stress
GO:0007399 nervous system development
GO:0007568 aging
GO:0009410 response to xenobiotic stimulus
GO:0016594 glycine binding
GO:0031667 response to nutrient levels
GO:0034612 response to tumor necrosis factor
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043200 response to amino acid
GO:0043295 glutathione binding
GO:0046686 response to cadmium ion
GO:0070062 extracellular exosome

Subcellular Location

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Domains

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DomainNameCategoryType
IPR004887 Glutathione synthase, substrate-binding domainDomainDomain
IPR005615 Glutathione synthaseFamilyFamily
IPR014042 Glutathione synthase, alpha-helicalFamilyHomologous superfamily
IPR014049 Glutathione synthase, N-terminal, eukaryoticFamilyHomologous superfamily
IPR014709 Glutathione synthase, C-terminal, eukaryoticFamilyHomologous superfamily
IPR016185 Pre-ATP-grasp domain superfamilyFamilyHomologous superfamily
IPR037013 Glutathione synthase, substrate-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00143 GlutathioneDrugbanksmall molecule
DB00145 GlycineDrugbanksmall molecule
DB00151 CysteineDrugbanksmall molecule
DB03408 gamma-GlutamylcysteineDrugbanksmall molecule
DB04395 Phosphoaminophosphonic Acid-Adenylate EsterDrugbanksmall molecule
DB06151 AcetylcysteineDrugbanksmall molecule
DB09130 CopperDrugbanksmall molecule