Entity Details

Primary name PAFA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13093
EntryNamePAFA_HUMAN
FullNamePlatelet-activating factor acetylhydrolase
TaxID9606
Evidenceevidence at protein level
Length441
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesPLA2G7

GO terms

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GOName
GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity
GO:0005543 phospholipid binding
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0034362 low-density lipoprotein particle
GO:0034364 high-density lipoprotein particle
GO:0034374 low-density lipoprotein particle remodeling
GO:0034440 lipid oxidation
GO:0034441 plasma lipoprotein particle oxidation
GO:0034638 phosphatidylcholine catabolic process
GO:0046469 platelet activating factor metabolic process
GO:0047499 calcium-independent phospholipase A2 activity
GO:0050729 positive regulation of inflammatory response
GO:0062234 platelet activating factor catabolic process
GO:0090026 positive regulation of monocyte chemotaxis

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR005065 Platelet-activating factor acetylhydrolase-likeFamilyFamily
IPR016715 Platelet-activating factor acetylhydrolase, eucaryoteFamilyFamily
IPR029058 Alpha/Beta hydrolase foldFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB05119 RilapladibDrugbanksmall molecule
DB07821 (1R)-1,2,2-trimethylpropyl (R)-methylphosphinateDrugbanksmall molecule

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
PAFA_HUMANTBA1A_HUMANHPRD9384577 details